种植体间距对种植体周骨吸收影响的Meta分析

doi:10.12337/zgkqzzxzz.2022.10.008

中国口腔种植学杂志 ›› 2022, Vol. 27 ›› Issue (5): 304-311.DOI: 10.12337/zgkqzzxzz.2022.10.008

种植体间距对种植体周骨吸收影响的Meta分析

张启航¹, 龚佳明^1,2, 苟萍¹, 余佳颖¹, 薄磊³, 余占海¹

¹兰州大学口腔医学院·口腔医院种植科 730000;
²解放军联勤保障部队第940医院口腔科,兰州 730050;
³93811部队口腔科,兰州 730020

收稿日期:2022-07-21 出版日期:2022-10-30 发布日期:2022-11-01
通讯作者: 余占海,Email：yuzhanhai@lzu.edu.cn,电话：0931-7716666
作者简介:张启航,硕士研究生在读,研究方向：口腔种植;余占海,教授、副主任医师、硕士研究生导师,研究方向：口腔种植
基金资助:
兰州大学口腔医院科研基金（lzukqky-2020-t07）

A meta-analysis of interimplant distance on peri-implant bone resorption

Zhang Qihang¹, Gong Jiaming^1,2, Gou Ping¹, Yu Jiaying¹, Bo Lei³, Yu Zhanhai¹

¹Department of Implantology, School of Stomatology, Lanzhou University, Lanzhou 730000, China;
²Department of Stomatology, 940 Hospital of People's Liberation Army of China Joint Logistic Support Force, Lanzhou 730005, China;
³The Outpatient Department of 93811 Army, Lanzhou 730020, China

Received:2022-07-21 Online:2022-10-30 Published:2022-11-01
Contact: Yu Zhanhai, Email: yuzhanhai@lzu.edu.cn, Tel: 0086-931-7716666
Supported by:
Hospital of Stomatology Lanzhou University Scientific Research Project (lzukqky-2020-t07)

摘要/Abstract

摘要： 目的通过系统评价及Meta分析的方法评估种植体间距（interimplant distance,IID）对种植体周骨吸收的影响。方法电子检索截至2022年3月PubMed、Embase、Cochrane Library、Web of Science、CNKI、万方数据库有关不同IID对种植体周骨吸收影响的人群或动物研究,且对关键文献进行引文索引。结果共9篇研究符合纳入标准,其中动物研究7篇,临床试验2篇。以3 mm作为标准IID,Meta分析结果：动物研究中IID=2 mm和IID=3 mm的边缘骨吸收量没有统计学差异[MD=0.05,95%CI（-0.10,0.19）,P=0.54];临床试验表明IID=2 mm时的边缘骨吸收量稍大于3 mm,但没有统计学意义[MD=0.11,95%CI（-0.09,0.31）,P=0.27]。IID=2 mm或3 mm时的垂直骨吸收量没有统计学差异[MD=-0.10,95%CI（-0.27,0.07）,P=0.24]。结论基于有限的证据,与IID=3 mm相比,IID=2 mm的表现与之相似。仍需要细化评估组别、改善评估方式,进一步证实IID与种植体周骨吸收的关系。

关键词: 种植体, 种植体间距, 边缘骨吸收, 垂直骨吸收, Meta分析

Abstract: Objective To systematically evaluate the effect of interimplant distance (IID) on peri-implant bone resorption by systematic evaluation and meta-analysis. Methods Databases in PubMed, Embase, Cochrane Library, Web of Science, CNKI and Wanfang Date until March 2022 were searched to identify animal studies or population studies that comparing peri-implant bone resorption at different IID, and citation indexes were carried out for the critical literatures. Results A total of 9 studies were included, including 7 animal studies and 2 clinical trials. Using 3 mm as the standard IID, meta-analysis indicated that there was no statistically significant difference in marginal bone resorption between IID=2 mm and IID=3 mm of animal studies [MD=0.05, 95%CI (-0.10,0.19), P=0.54]; Clinical trials showed slightly greater marginal bone resorption at IID=2 mm than at IID=3 mm, which is not statistically significant [MD=0.11, 95%CI (-0.09,0.31), P=0.27]. There was no statistically significant difference in vertical bone resorption at IID=2 mm or 3 mm [MD=-0.10,95%CI (-0.27,0.07), P=0.24]. Conclusion sBased on the limited evidence, performance was similar for IID=2 mm compared to IID=3 mm. There is still a need to refine the assessment groups, improve the assessment methods and further confirm the relationship between IID and peri-implant bone resorption.

Key words: Dental implant, Interimplant distance, Marginal bone resorption, Vertical bone resorption, Meta-analysis

张启航,龚佳明,苟萍,等. 种植体间距对种植体周骨吸收影响的Meta分析[J]. 中国口腔种植学杂志, 2022, 27(5): 304-311. DOI: 10.12337/zgkqzzxzz.2022.10.008

Zhang Qihang, Gong Jiaming, Gou Ping, Yu Jiaying, Bo Lei, Yu Zhanhai. A meta-analysis of interimplant distance on peri-implant bone resorption[J].Chinese Journal of Oral Implantology, 2022, 27(5): 304-311.DOI: 10.12337/zgkqzzxzz.2022.10.008.

参考文献

[1] Staedt H, Rossa M, Lehmann KM, et al.Potential risk factors for early and late dental implant failure: a retrospective clinical study on 9080 implants[J]. Int J Implant Dent, 2020,6(1):81. DOI: 10.1186/s40729-020-00276-w.
[2] 迟义凡, 王宏浩, 张磊, 等. 种植体早、晚期失败相关危险因素的对比研究[J].中国口腔种植学杂志,2021,26(3): 164-168. DOI: 10.12337/zgkqzzxzz.2021.06.004.
[3] 章惠娅, 林国芬, 管叶, 等. 种植体早期失败的相关因素分析[J].口腔医学,2020,40(6):526-530. DOI: 10.13591/j.cnki.kqyx.2020.06.010.
[4] Wu X, Chen S, Ji W, et al.The risk factors of early implant failure: a retrospective study of 6113 implants[J]. Clin Implant Dent Relat Res, 2021,23(3):280-288. DOI: 10.1111/cid.12992.
[5] 黄云生, 戚晓峰, 李勇. 口腔种植体整合效果的影响因素分析[J].中国医药导报,2022,19(15):121-124.
[6] Abdelhay N, Prasad S, Gibson MP.Failure rates associated with guided versus non-guided dental implant placement: a systematic review and meta-analysis[J]. BDJ Open, 2021,7(1):31. DOI: 10.1038/s41405-021-00086-1.
[7] Zheng Z, Ao X, Xie P, et al.The biological width around implant[J]. J Prosthodont Res, 2021,65(1):11-18. DOI: 10.2186/jpr.JPOR_2019_356.
[8] Barros RR, Novaes AB Jr, Muglia VA, et al.Influence of interimplant distances and placement depth on peri-implant bone remodeling of adjacent and immediately loaded morse cone connection implants: a histomorphometric study in dogs[J]. Clin Oral Implants Res, 2010,21(4):371-378. DOI: 10.1111/j.1600-0501.2009.01860.x.
[9] Elian N, Bloom M, Dard M, et al.Effect of interimplant distance (2 and 3 mm) on the height of interimplant bone crest: a histomorphometric evaluation[J]. J Periodontol, 2011,82(12):1749-1756. DOI: 10.1902/jop.2011.100661.
[10] Elian N, Bloom M, Trushkowsky RD, et al.Effect of 3- and 4-mm interimplant distances on the height of interimplant bone crest: a histomorphometric evaluation measured on bone level dental implants in minipig[J]. Implant Dent, 2014,23(5):522-528. DOI: 10.1097/ID.0000000000000153.
[11] Koutouzis T, Neiva R, Lipton D, et al.The effect of interimplant distance on peri-implant bone and soft tissue dimensional changes: a nonrandomized, prospective, 2-year follow-up study[J]. Int J Oral Maxillofac Implants, 2015,30(4):900-908. DOI: 10.11607/jomi.4040.
[12] Scarano A, Assenza B, Piattelli M, et al.Interimplant distance and crestal bone resorption: a histologic study in the canine mandible[J]. Clin Implant Dent Relat Res, 2004,6(3):150-156. DOI: 10.1111/j.1708-8208.2004.tb00222.x.
[13] Novaes AB Jr, Papalexiou V, Muglia V, et al.Influence of interimplant distance on gingival papilla formation and bone resorption: clinical-radiographic study in dogs[J]. Int J Oral Maxillofac Implants, 2006,21(1):45-51.
[14] Novaes AB Jr, Barros RR, Muglia VA, et al.Influence of interimplant distances and placement depth on papilla formation and crestal resorption: a clinical and radiographic study in dogs[J]. J Oral Implantol, 2009,35(1):18-27. DOI: 10.1563/1548-1336-35.1.18.
[15] Elian N, Bloom M, Dard M, et al.Radiological and micro-computed tomography analysis of the bone at dental implants inserted 2, 3 and 4 mm apart in a minipig model with platform switching incorporated[J]. Clin Oral Implants Res, 2014,25(2):e22-29. DOI: 10.1111/clr.12037.
[16] De Oliveira RR, Novaes AB Jr, Papalexiou V, et al.Influence of interimplant distance on papilla formation and bone resorption: a clinical-radiographic study in dogs[J]. J Oral Implantol, 2006,32(5):218-227. DOI: 10.1563/793.1.
[17] Rivara F, Macaluso GM, Toffoli A, et al.The effect of a 2-mm inter-implant distance on esthetic outcomes in immediately non-occlusally loaded platform shifted implants in healed ridges: 12-month results of a randomized clinical trial[J]. Clin Implant Dent Relat Res, 2020,22(4):486-496. DOI: 10.1111/cid.12926.
[18] Al Amri MD. Influence of interimplant distance on the crestal bone height around dental implants: a systematic review and meta-analysis[J]. J Prosthet Dent, 2016,115(3):278-282.e1. DOI: 10.1016/j.prosdent.2015.09.001.
[19] Chacun D, Lafon A, Courtois N, et al.Histologic and histomorphometric evaluation of new zirconia-based ceramic dental implants: a preclinical study in dogs[J]. Dent Mater, 2021,37(9):1377-1389. DOI: 10.1016/j.dental.2021.06.010.
[20] Ryan LL, Kohles SS.A temporospatial histomorphometric analysis of bone density adjacent to acid-etched self-tapping dental implants with an external hexagon connection in the female baboon[J]. Clin Oral Investig, 2022,26(2):2143-2154. DOI: 10.1007/s00784-021-04195-x.
[21] Anchieta RB, Guimarães M, Suzuki M, et al.Nanomechanical assessment of bone surrounding implants loaded for 3 years in a canine experimental model[J]. J Oral Maxillofac Surg, 2018,76(1):71-79. DOI: 10.1016/j.joms.2017.08.016.
[22] Yang BC, Zhou XD, Yu HY, et al.Advances in titanium dental implant surface modification[J]. Hua Xi Kou Qiang Yi Xue Za Zhi, 2019,37(2):124-129. DOI: 10.7518/hxkq.2019.02.002.
[23] Canullo L, Annunziata M, Pesce P, et al.Influence of abutment material and modifications on peri-implant soft-tissue attachment: a systematic review and meta-analysis of histological animal studies[J]. J Prosthet Dent, 2021,125(3):426-436. DOI: 10.1016/j.prosdent.2020.01.025.
[24] Lin CP, Lu SH, Zhu JX, et al.Influence of thread shapes of custom made root-analogue implants on stress distribution of peri-implant bone: a three-dimensional finite element analysis[J]. Beijing Da Xue Xue Bao Yi Xue Ban, 2019,51(6):1130-1137. DOI: 10.19723/j.issn.1671-167X.2019.06.027.
[25] Juan-Montesinos A, Agustín-Panadero R, Solá-Ruiz MF, et al. Comparative study by systematic review and meta-analysis of the peri-implant effect of two types of platforms: platform-switching versus conventional platforms[J]. J Clin Med, 2022,11(6)DOI: 10.3390/jcm11061743.
[26] Tokgöz SE, Bilhan H.The influence of the implant-abutment complex on marginal bone and peri-implant conditions: a retrospective study[J]. J Adv Prosthodont, 2021,13(1):46-54. DOI: 10.4047/jap.2021.13.1.46.
[27] Juan-Montesinos A, Agustín-Panadero R, Solá-Ruiz MF, et al.Comparative study by systematic review and meta-analysis of the peri-implant effect of two types of platforms: platform-switching versus conventional platforms[J]. J Clin Med, 2022,11(6):1743. DOI: 10.3390/jcm11061743.
[28] 张倩, 周益, 王慧明. 种植体平台转移设计研究进展[J].口腔医学,2019,39(4):365-370. DOI: 10.13591/j.cnki.kqyx.2019.04.017.
[29] Palacios-Garzón N, Velasco-Ortega E, López-López J.Bone loss in implants placed at subcrestal and crestal level: a systematic review and meta-analysis[J]. Materials (Basel), 2019,12(1):154. DOI: 10.3390/ma12010154.
[30] 黄江琴, 王轶, 岑雯, 等. 种植体植入深度对边缘骨水平影响的临床研究[J].中国口腔种植学杂志,2019,34(1):14-18. DOI: 10.3969/j.issn.1007-3957.2019.01.004.
[31] Palacios-Garzón N, Mauri-Obradors E, Ayuso-Montero R, et al.Marginal bone loss in internal conical connection implants placed at the crestal and subcrestal levels before prosthetic loading: A randomized clinical study[J]. Materials (Basel), 2022,15(10):3729. DOI: 10.3390/ma15103729.
[32] Sargolzaie N, Zarch HH, Arab H, et al.Marginal bone loss around crestal or subcrestal dental implants: prospective clinical study[J]. J Korean Assoc Oral Maxillofac Surg, 2022,48(3):159-166. DOI: 10.5125/jkaoms.2022.48.3.159.
[33] Sanz-Esporrin J, Carral C, Blanco J, et al.Differences in the progression of experimental peri-implantitis depending on the implant to abutment connection[J]. Clin Oral Investig, 2021,25(6):3577-3587. DOI: 10.1007/s00784-020-03680-z.
[34] Ercal P, Taysi AE, Ayvalioglu DC, et al.Impact of peri-implant bone resorption, prosthetic materials, and crown to implant ratio on the stress distribution of short implants: a finite element analysis[J]. Med Biol Eng Comput, 2021,59(4):813-824. DOI: 10.1007/s11517-021-02342-w.

种植体间距对种植体周骨吸收影响的Meta分析

A meta-analysis of interimplant distance on peri-implant bone resorption

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