聚氨酯人造骨在口腔植入物体外研究中的应用现状

doi:10.12337/zgkqzzxzz.2022.09.009

中国口腔种植学杂志 ›› 2022, Vol. 27 ›› Issue (5): 312-316.DOI: 10.12337/zgkqzzxzz.2022.09.009

聚氨酯人造骨在口腔植入物体外研究中的应用现状

滕微微¹, 苏天月¹, 王琦¹, 舒倩怡², 周立波¹, 侯玉泽¹

¹佳木斯大学附属口腔医院黑龙江省口腔生物医学材料及临床应用重点实验室154000;
²中国医学科学院北京协和医院 100730

收稿日期:2022-04-09 出版日期:2022-10-30 发布日期:2022-11-01
通讯作者: 周立波,Email：zhoulibo0219@gmail.com,电话：0454-8625462
作者简介:滕微微,硕士研究生在读,研究方向：数字化口腔种植;周立波,副主任医师、硕士研究生导师,研究方向：数字化口腔种植
基金资助:
黑龙江省自然科学基金项目（LH2021H10）; 黑龙江省普通高等学校青年创新人才培养计划项目（UNPYSCT-2020057）; 佳木斯大学青年创新人才培养支持计划项目（JMSUQP2020020）

Current status of the use of polyurethane artificial bone in vitro studies of dental implants

Teng Weiwei¹, Su Tianyue¹, Wang Qi¹, Shu Qianyi², Zhou Libo¹, Hou Yuze¹

¹Affiliated Stomatological Hospital,Jiamusi University, Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application, Hei Longjiang Jiamusi 154000, China;
²Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beiing 100730, China

Received:2022-04-09 Online:2022-10-30 Published:2022-11-01
Contact: Zhou Libo, Email: zhoulibo0219@gmail.com, Tel: 0086-454-8625462
Supported by:
Natural Science Foundation of Heilongjiang Province (LH2021H10); Heilongjiang Province General Higher Education Institution Young Innovative Talents Training Program (UNPYSCT-2020057); Jiamusi University Youth Innovative Talents Training Support Program (JMSUQP2020020)

摘要/Abstract

摘要： 随着种植牙、正畸支抗螺钉、颌骨骨折固定装置等口腔植入物在临床的广泛应用,口腔植入物的生物力学性能以及植入物植入准确性等已成为人们关注的热点之一,这些都需要通过大量体内、体外实验研究得以明确。而体外研究需要实验模型,建立标准的实验模型是开展体外研究的基础,因此有必要寻找或建立符合标准的实验模型。目前,口腔医学领域对于植入物体外研究的实验模型选择尚未见权威标准形成。文献中报道的实验模型有石膏类、丙烯酸类、聚氨酯类等,其中聚氨酯类因其材料模型与骨的特性相似,已在体外研究中得到广泛应用。因此本文针对聚氨酯类实验模型在口腔植入物体外研究中的应用情况及其尚存的优势、不足与未来展望做一综述,希望能为未来口腔植入物研究的体外模型选择提供参考。

关键词: 口腔植入物, 聚氨酯, 体外研究, 实验模型

Abstract: With the widespread use of dental implants,dental implants,orthodontic anchorage screws,jaw fracture fixation devices and other oral implants in clinical practice, the biomechanical properties of oral implants and the accuracy of implant placement have become one of the focuses in stomatology. These need to be clarified through a large number of in vivo and vitro experimental studies. However, in vitro study needs experimental models, and the establishment of standard experimental models is the basis for in vitro study. Therefore, it is necessary to find or establish experimental models that meet the standards. At present, there is no authoritative standard for in vitro studies of implants in the field of stomatology. The experimental models reported in the literature include gypsum, acrylic, and polyurethane. Among them, polyurethanes have been widely used in in vitro studies because of their similar properties to those of bone. Therefore, this paper summarizes the application of polyurethane experimental models in in vitro researches of oral implants, its remaining advantages, disadvantages and future prospects, hoping to provide a reference for the selection of in vitro models for future oral implant research.

Key words: Dental implant, Polyurethane, In vitro study, Experimental model

滕微微,苏天月,王琦,等. 聚氨酯人造骨在口腔植入物体外研究中的应用现状[J]. 中国口腔种植学杂志, 2022, 27(5): 312-316. DOI: 10.12337/zgkqzzxzz.2022.09.009

Teng Weiwei, Su Tianyue, Wang Qi, Shu Qianyi, Zhou Libo, Hou Yuze. Current status of the use of polyurethane artificial bone in vitro studies of dental implants[J].Chinese Journal of Oral Implantology, 2022, 27(5): 312-316.DOI: 10.12337/zgkqzzxzz.2022.09.009.

参考文献

[1] Wang R, Eppell SJ, Nguyen C, et al.Relative contribution of trabecular and cortical bone to primary implant stability: an in vitro model study[J]. J Oral Implantol, 2016,42(2):145-152. DOI: 10.1563/aaid-joi-D-14-00322.
[2] Bredbenner TL, Haug RH.Substitutes for human cadaveric bone in maxillofacial rigid fixation research[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2000,90(5):574-580. DOI: 10.1067/moe.2000.111025.
[3] Kessler A, Le V, Folwaczny M.Influence of the tooth position, guided sleeve height, supporting length, manufacturing methods, and resin E-modulus on the in vitro accuracy of surgical implant guides in a free-end situation[J]. Clin Oral Implants Res. 2021,32(9):1097-1104. DOI: 10.1111/clr.13804.
[4] Choi HH, Chung CH, Kim SG, et al.Reliability of 2 implant stability measuring methods in assessment of various periimplant bone loss: an in vitro study with the Periotest and Osstell Mentor. Implant Dent[J]. 2014, 23(1):51-56. DOI: 10.1097/ID.0000000000000000.
[5] Wu AY, Lung H, Huang HL, et al.Biomechanical investigations of the expanded platform-switching concept in immediately loaded small diameter implants[J]. J Prosthet Dent, 2016,115(1):20-25. DOI: 10.1016/j.prosdent.2015.08.005.
[6] Alameldeen HE, Elsyad MA, Shawky AF, et al.The influence of implant inclination on retention and peri-implant stresses of stud-retained implant overdentures during axial and nonaxial dislodgments: an in vitro study[J]. Int J Oral Maxillofac Implants, 2020,35(3):543-550. DOI: 10.11607/jomi.7954.
[7] Libor M, Milena Š, Jiří D,et al.Structure evolution during order-disorder transitions in aliphatic polycarbonate based polyurethanes. Self-healing polymer[J]. Chem Eng J,2019, 357:611-624.DOI:10. 1016/j.cej.2018.09.118.
[8] Raz P, Meir H, Levartovsky S, et al.Reliability and correlation of different devices for the evaluation of primary implant stability: an in vitro study[J]. Materials (Basel), 2021,14(19):5537. DOI: 10.3390/ma14195537.
[9] Chávarri-Prado D, Brizuela-Velasco A, Diéguez-Pereira M, et al.Influence of cortical bone and implant design in the primary stability of dental implants measured by two different devices of resonance frequency analysis: an in vitro study[J]. J Clin Exp Dent, 2020,12(3):e242-e248. DOI: 10.4317/jced.56014.
[10] Gehrke SA, Guirado J, Bettach R, et al.Evaluation of the insertion torque, implant stability quotient and drilled hole quality for different drill design: an in vitro Investigation[J]. Clin Oral Implants Res, 2018,29(6):656-662. DOI: 10.1111/clr.12808.
[11] Goellner M, Schmitt J, Karl M, et al.The effect of axial and oblique loading on the micromovement of dental implants[J]. Int J Oral Maxillofac Implants, 2011,26(2):257-264.
[12] Huang HL, Tsai MT, Su KC, et al.Relation between initial implant stability quotient and bone-implant contact percentage: an in vitro model study[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013,116(5):e356-361. DOI: 10.1016/j.oooo.2012.01.037.
[13] Comuzzi L, Iezzi G, Piattelli A, et al.An in vitro evaluation, on polyurethane foam sheets, of the insertion torque (it) values, pull-out torque values, and resonance frequency analysis (RFA) of nanoshort dental implants[J]. Polymers (Basel), 2019,11(6):1020. DOI: 10.3390/polym11061020.
[14] Devlin H, Horner K, Ledgerton D.A comparison of maxillary and mandibular bone mineral densities[J]. J Prosthet Dent, 1998,79(3):323-327. DOI: 10.1016/s0022-3913(98)70245-8.
[15] Sugiura T, Yamamoto K, Horita S, et al.Evaluation of primary stability of cylindrical and tapered implants in different bone types by measuring implant displacement: an in vitro study[J]. Contemp Clin Dent, 2019,10(3):471-476. DOI: 10.4103/ccd.ccd_788_18.
[16] Ko YC, Huang HL, Shen YW, et al.Variations in crestal cortical bone thickness at dental implant sites in different regions of the jawbone[J]. Clin Implant Dent Relat Res, 2017,19(3):440-446. DOI: 10.1111/cid.12468.
[17] Sierra-Rebolledo A, Allais-Leon M, Maurette-OʼBrien P, et al. Primary apical stability of tapered implants through reduction of final drilling dimensions in different bone density models: a biomechanical study[J]. Implant Dent, 2016,25(6):775-782. DOI: 10.1097/ID.0000000000000479.
[18] Misch CE, Qu Z, Bidez MW.Mechanical properties of trabecular bone in the human mandible: implications for dental implant treatment planning and surgical placement[J]. J Oral Maxillofac Surg, 1999,57(6):700-708. DOI: 10.1016/s0278-2391(99)90437-8.
[19] Huang HL, Chang YY, Lin DJ, et al.Initial stability and bone strain evaluation of the immediately loaded dental implant: an in vitro model study[J]. Clin Oral Implants Res, 2011,22(7):691-698. DOI: 10.1111/j.1600-0501.2010.01983.x.
[20] Hsu JT, Huang HL, Tsai MT, et al.Effects of the 3D bone-to-implant contact and bone stiffness on the initial stability of a dental implant: micro-CT and resonance frequency analyses[J]. Int J Oral Maxillofac Surg, 2013,42(2):276-280. DOI: 10.1016/j.ijom.2012.07.002.
[21] Pan CY, Liu PH, Tseng YC, et al.Effects of cortical bone thickness and trabecular bone density on primary stability of orthodontic mini-implants[J]. J Dent Sci, 2019,14(4):383-388. DOI: 10.1016/j.jds.2019.06.002.
[22] Mediavilla Guzmán A, Riad Deglow E, Zubizarreta-Macho Á, et al.Accuracy of computer-aided dynamic navigation compared to computer-aided static navigation for dental implant placement: an in vitro study[J]. J Clin Med, 2019,8(12):2123. DOI: 10.3390/jcm8122123.
[23] Yimarj P, Subbalekha K, Dhanesuan K, et al.Comparison of the accuracy of implant position for two-implants supported fixed dental prosthesis using static and dynamic computer-assisted implant surgery: a randomized controlled clinical trial[J]. Clin Implant Dent Relat Res, 2020,22(6):672-678. DOI: 10.1111/cid.12949.
[24] Lee JS, Kim DH, Park YC, et al.The efficient use of midpalatal miniscrew implants[J]. Angle Orthod, 2004,74(5):711-714. DOI: 10.1043/0003-3219(2004)074<0711:TEUOMM>2.0.CO;2.
[25] Bae MJ, Kim JY, Park JT, et al.Accuracy of miniscrew surgical guides assessed from cone-beam computed tomography and digital models[J]. Am J Orthod Dentofacial Orthop, 2013,143(6):893-901. DOI: 10.1016/j.ajodo.2013.02.018.
[26] Cha JY, Hwang CJ, Kwon SH, et al.Strain of bone-implant interface and insertion torque regarding different miniscrew thread designs using an artificial bone model[J]. Eur J Orthod, 2015,37(3):268-274. DOI: 10.1093/ejo/cju037.
[27] Pan CY, Liu PH, Tseng YC, et al.Effects of cortical bone thickness and trabecular bone density on primary stability of orthodontic mini-implants[J]. J Dent Sci, 2019,14(4):383-388. DOI: 10.1016/j.jds.2019.06.002.
[28] Chang JZ, Chen YJ, Tung YY, et al.Effects of thread depth, taper shape, and taper length on the mechanical properties of mini-implants[J]. Am J Orthod Dentofacial Orthop, 2012,141(3):279-288. DOI: 10.1016/j.ajodo.2011.09.008.
[29] Armstrong JE, Lapointe HJ, Hogg NJ, et al.Preliminary investigation of the biomechanics of internal fixation of sagittal split osteotomies with miniplates using a newly designed in vitro testing model[J]. J Oral Maxillofac Surg, 2001,59(2):191-195. DOI: 10.1053/joms.2001.20492.
[30] Lieger O, Schaller B, Bürki A, et al.Biomechanical evaluation of different angle-stable locking plate systems for mandibular surgery[J]. J Craniomaxillofac Surg, 2015,43(8):1589-1594. DOI: 10.1016/j.jcms.2015.06.047.
[31] Pereira-Filho VA, da Silva BN, Nunes Reis JM, et al. Effect of the number of screws on the stability of locking mandibular reconstruction plates[J]. Int J Oral Maxillofac Surg, 2013,42(6):732-735. DOI: 10.1016/j.ijom.2013.02.010.
[32] Kolsuz N, Atali O, Varol A.Assessment of biomechanical properties of specially-designed miniplate patterns in a mandibular subcondylar fracture model with finite element analysis and a servohydraulic testing unit[J]. Br J Oral Maxillofac Surg, 2020,58(7):848-853. DOI: 10.1016/j.bjoms.2020.04.053.
[33] Polat ME, Dayi E, 赵泽亮. 体外评价不同固定方法对下颌骨骨折稳定性的影响[J].中国口腔颌面外科杂志,2019,(3):279.

聚氨酯人造骨在口腔植入物体外研究中的应用现状

Current status of the use of polyurethane artificial bone in vitro studies of dental implants

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