血浆基质在种植体周角化黏膜增宽中的临床应用

doi:10.12337/zgkqzzxzz.2025.12.005

中国口腔种植学杂志 ›› 2025, Vol. 30 ›› Issue (6): 536-540.DOI: 10.12337/zgkqzzxzz.2025.12.005

• 软组织增量与牙种植专题 • 上一篇下一篇

血浆基质在种植体周角化黏膜增宽中的临床应用

邱韵^1,2, 李永军³, 张晓欣^1,4, 王宇蓝^1,4, 曾浩^1,4

¹口颌系统重建与再生全国重点实验室口腔生物医学教育部重点实验室口腔医学湖北省重点实验室武汉大学口腔医学院 430079;
²武汉大学口腔医院光谷院区种植与修复中心 430223;
³武汉大众口腔医院 430070;
⁴武汉大学口腔医学院种植科 430079

收稿日期:2025-09-05 出版日期:2025-12-30 发布日期:2025-12-23
通讯作者: 曾浩,Email：hao.zeng@whu.edu.cn,电话：027-87686222
作者简介:邱韵,口腔医学博士、主治医师,研究方向：牙周软硬组织再生。
曾浩,口腔医学博士、副主任医师,研究方向：骨组织工程与种植体表面载药。
基金资助:
国家自然科学基金（82401192）

The use of plasmatrix in peri-implant keratinized mucosa augmentation

Qiu Yun^1,2, Li Yongjun³, Zhang Xiaoxin^1,4, Wang Yulan^1,4, Zeng Hao^1,4

¹State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine, Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei, China;
²Center for Prosthodontics and Implant Dentistry, Optics Valley Branch, School and Hospital of Stomatology, Wuhan University, Wuhan 430223, Hubei, China;
³Wuhan Dazhong Dental Hospital, Wuhan 430070, Hubei, China;
⁴Department of Implantology, Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei, China

Received:2025-09-05 Online:2025-12-30 Published:2025-12-23
Contact: Zeng Hao, Email: hao.zeng@whu.edu.cn, Tel: 0086-27-87686222
Supported by:
National Natural Science Foundation of China (82401192)

摘要/Abstract

摘要： 充足的种植体周角化黏膜宽度对减少菌斑附着、降低种植体周黏膜炎发生率、维持种植体长期健康具有重要意义。目前虽有多种材料可用于增宽种植体周角化黏膜,但自体移植物存在手术创伤大的问题,人工替代材料则面临价格高昂的局限。血浆基质是经自体血液离心制备的产物,富含大量生长因子及天然支架结构,具有生物相容性优异、取材创伤小、来源充足及应用成本低的优势。将血浆基质应用于种植体周角化黏膜增宽,有望解决现有材料的问题。本文基于现有证据,系统介绍血浆基质的制备流程,并分享其在种植体周角化黏膜增宽中的临床应用经验,以期为临床医生提供实践参考。

关键词: 血浆基质, 种植体周角化黏膜, 角化黏膜增宽

Abstract: An adequate width of peri-implant keratinized mucosa is crucial for reducing plaque accumulation, decreasing the incidence of peri-implant mucositis, and maintaining long-term implant health. Although various materials are currently available to widen the peri-implant keratinized mucosa, autografts are associated with considerable surgical trauma, whereas artificial substitutes are often limited by high costs. Plasmatrix,a centrifuged autologous blood product rich in growth factors and scaffold-like structures, offers advantages such as excellent biocompatibility, minimal donor-site morbidity, abundant availability, and low cost. Its application for peri-implant keratinized mucosa augmentation may help overcome the limitations of existing materials. Based on current evidence, this article presents the preparation protocol for plasmatrix and clinical experiences with its use in peri-implant keratinized mucosa augmentation, thereby providing practical guidance for clinicians.

Key words: Plasmatrix, Peri-implant keratinized mucosa, Keratinized mucosa width augmentation

邱韵,李永军,张晓欣,等. 血浆基质在种植体周角化黏膜增宽中的临床应用[J]. 中国口腔种植学杂志, 2025, 30(6): 536-540. DOI: 10.12337/zgkqzzxzz.2025.12.005

Qiu Yun, Li Yongjun, Zhang Xiaoxin, Wang Yulan, Zeng Hao. The use of plasmatrix in peri-implant keratinized mucosa augmentation[J].Chinese Journal of Oral Implantology, 2025, 30(6): 536-540.DOI: 10.12337/zgkqzzxzz.2025.12.005.

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血浆基质在种植体周角化黏膜增宽中的临床应用

The use of plasmatrix in peri-implant keratinized mucosa augmentation

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