两种不同螺纹设计的牙种植体在犬颌骨中骨结合的对比研究

doi:10.12337/zgkqzzxzz.2021.08.004

中国口腔种植学杂志 ›› 2021, Vol. 26 ›› Issue (4): 226-231.DOI: 10.12337/zgkqzzxzz.2021.08.004

两种不同螺纹设计的牙种植体在犬颌骨中骨结合的对比研究

刘成武¹, 刘远翔¹, 李志鹏², 刘泉¹, 武诗语¹, 吴夏怡¹, 陈泽涛², 黄宝鑫², 陈卓凡¹

¹中山大学光华口腔医学院·附属口腔医院珠江新城门诊·广东省口腔医学重点实验室,广州 510623;
²中山大学光华口腔医学院·附属口腔医院口腔种植科·广东省口腔医学重点实验室,广州 510055

收稿日期:2021-06-04 出版日期:2021-08-10 发布日期:2021-09-08
通讯作者: 陈卓凡,Email：chzhuof@mail.sysu.edu.cn,电话：020-38032494
作者简介:刘成武医师、口腔种植学硕士,研究方向：氟化猪骨源磷灰石的骨免疫调控及植体表面改性;陈卓凡博士、主任医师、教授、博士生导师,研究方向：口腔种植相关的软硬组织再生
基金资助:
国家自然科学基金（ 81970975, 82001095）

The effects of different thread designs on osseointegration of dental implants: a comparative experimental study in canine jaw

Liu Chengwu¹, Liu Yuanxiang¹, Li Zhipeng², Liu Quan¹, Wu Shiyu¹, Wu Xiayi¹, Chen Zetao², Huang Baoxin², Chen Zhuofan¹

¹Department of Zhujiang New Town Dental Clinic, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510623, China;
²Department of Oral Implantology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China

Received:2021-06-04 Online:2021-08-10 Published:2021-09-08
Contact: Chen Zhuofan, Email: chzhuof@mail.sysu.edu.cn, Tel: 0086-20-38032494
Supported by:
National Natural Science Foundation of China (81970975, 82001095)

摘要/Abstract

摘要： 目的评价两种不同螺纹设计的牙种植体在比格犬下颌骨中不同时期的骨结合情况。方法选取纯种雄性比格犬4只,分别拔除双侧下颌第二前磨牙至第二磨牙,愈合12周。选择两种不同螺纹设计的牙种植体作为实验组和对照组,采取左右对照原则,每侧植入4颗相同种植体,埋入式愈合。术后2周和12周分别处死2只动物取材（n=8）。通过口内X线片和不脱钙硬组织切片进行放射线和组织学评估。结果 X线片示两组种植体在不同时期的骨结合情况相似。组织学结果显示2周时植体与宿主骨主要为机械嵌合,种植体周围有少量新生骨形成;12周时种植体周围形成了大量矿化成熟的新生骨组织和骨小梁样结构。实验组和对照组种植体中段的骨结合率（bone-implant contact,BIC%）分别为（46.69±8.47）%和（36.71±13.72）%（2周）,（67.27±7.46）%和（56.63±8.31）%（12周）,两组间差异均无统计学意义。结论两种不同螺纹设计的牙种植体均能获得满意且相当的骨结合效果。

关键词: 牙种植体, 螺纹设计, 骨结合, 延期种植, 比格犬

Abstract: Objective To evaluate the osseointegration of dental implants with different thread designs in the canine mandible. Methods Four male beagle dogs were selected. Bilateral mandibular premolars and molars (PM2-M2) were extracted and allowed to heal for 12 weeks. The test group was a newly-designed dental implant, and the control group was AstraTech OsseoSpeed^TM TX dental implant. Four implants were implanted (submerged healing) on each side with a split-mouth design. Two animals were sacrificed at 2 and 12 weeks after surgery, respectively (n=8). Intraoral digital X-ray images and non-decalcified hard tissue sections were used for radiological and histological evaluations. Results Radiological images showed similar bone healing in two groups at 2 and 12 weeks after surgery. The histological results showed that at 2 weeks, implants were mainly mechanically inbuilt into the host bone, and a small number of new bones were formed around implants. At 12 weeks, a large number of completely mineralized new bones with the trabecular-liked structure was formed around implants. The bone-implant contact (BIC%) of the test and control group were (46.69±8.47) % and (36.71±13.72) % at 2 weeks, (67.27±7.46) % and (56.63±8.31) % at 12 weeks, respectively, and the difference between groups was not statistically significant. Conclusions Two dental implants with different thread shapes can achieve satisfactory and comparable osseointegration.

Key words: Dental implant, Thread design, Osseointegration, Delayed implant model, Beagle dogs

刘成武,刘远翔,李志鹏,等. 两种不同螺纹设计的牙种植体在犬颌骨中骨结合的对比研究[J]. 中国口腔种植学杂志, 2021, 26(4): 226-231. DOI: 10.12337/zgkqzzxzz.2021.08.004

Liu Chengwu, Liu Yuanxiang, Li Zhipeng, Liu Quan, Wu Shiyu, Wu Xiayi, Chen Zetao, Huang Baoxin, Chen Zhuofan. The effects of different thread designs on osseointegration of dental implants: a comparative experimental study in canine jaw[J].Chinese Journal of Oral Implantology, 2021, 26(4): 226-231.DOI: 10.12337/zgkqzzxzz.2021.08.004.

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两种不同螺纹设计的牙种植体在犬颌骨中骨结合的对比研究

The effects of different thread designs on osseointegration of dental implants: a comparative experimental study in canine jaw

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