Wnt/ Ca2+/CaMKⅡ信号通路在成骨调控及糖尿病骨代谢异常中作用机制的研究进展

doi:10.12337/zgkqzzxzz.2025.06.016

中国口腔种植学杂志 ›› 2025, Vol. 30 ›› Issue (3): 305-311.DOI: 10.12337/zgkqzzxzz.2025.06.016

Wnt/ Ca²⁺/CaMKⅡ信号通路在成骨调控及糖尿病骨代谢异常中作用机制的研究进展

丁佳琪¹, 周文娟^1,2,3

¹滨州医学院附属烟台口腔医院口腔种植科 264003;
²数字化口腔医学山东省高校特色实验室,烟台 264003;
³数字化口腔医学技术烟台市工程研究中心 264003

收稿日期:2025-03-17 出版日期:2025-06-30 发布日期:2025-06-27
通讯作者: 周文娟,Email：zhouwenjuan1004@163.com,电话：0535-6020160
作者简介:丁佳琪,硕士研究生在读,研究方向：口腔种植学、糖尿病与骨代谢的关系。
周文娟,副教授、博士、主任医师、硕士研究生导师,研究方向：系统性疾病与种植体骨结合、数字化口腔种植外科相关研究
基金资助:
国家自然科学基金委青年项目（82201110）

Research progress on the role and mechanism of the Wnt/Ca²⁺/CaMKⅡsignaling pathway in osteogenic regulation and diabetic bone metabolism disorders

Ding Jiaqi¹, Zhou Wenjuan^1,2,3

¹Department of Implant Dentistry, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai 264003, China;
²Characteristic Laboratories of Colleges and Universities in Shandong Province for Digital Stomatology, Yantai 264003, China;
³Yantai Engineering Research Center for Digital Technology of Stomatology, Yantai 264003, China

Received:2025-03-17 Online:2025-06-30 Published:2025-06-27
Contact: Zhou Wenjuan, Email: zhouwenjuan1004@163.com, Tel: 0086-535-6020160
Supported by:
National Natural Science Foundation of China Young Scientist Fund (82201110)

摘要/Abstract

摘要： 糖尿病是一种常见的慢性代谢性疾病,与骨代谢平衡异常密切相关,可通过多种途径影响成骨细胞活性,进而导致骨代谢异常。与此同时,糖尿病氧化应激也会严重影响新骨的形成过程,导致种植体骨结合不良,甚至种植体失败。Wnt/Ca²⁺/CaMK Ⅱ信号通路在骨形成过程中起重要作用,参与调控成骨细胞分化、骨基质合成及骨组织重塑。本综述重点探讨了Wnt/Ca²⁺/CaMK Ⅱ信号通路对糖尿病骨代谢平衡的影响,明确了该通路在糖尿病骨代谢紊乱中的相关作用机制,还讨论了该信号通路作为糖尿病相关骨质病变治疗靶点的应用前景,为代谢性骨病及糖尿病患者种植体骨结合不良的干预提供思路。

关键词: Wnt/Ca²⁺/CaMK Ⅱ信号通路, 成骨作用, 糖尿病, 骨代谢

Abstract: Diabetes mellitus (DM), a prevalent chronic metabolic disorder, is closely associated with disrupted bone metabolic homeostasis, which can impair osteoblast function through various molecular pathways, ultimately leading to abnormal bone metabolism. Additionally, diabetic oxidative stress can severely impair the process of new bone formation, leading to compromised osseointegration of the implant and even implant failure. Among these pathways, the Wnt/Ca²⁺/CaMKⅡ signaling axis plays a pivotal role in regulating osteoblast differentiation, bone matrix synthesis, and bone remodeling, all of which are essential processes in bone formation. This review systematically examines the impact of the Wnt/Ca²⁺/CaMKⅡ pathway on bone metabolic homeostasis in diabetic conditions, with a focus on the molecular mechanisms underlying diabetic bone metabolism disorders. Furthermore, the review discusses the potential of the Wnt/Ca²⁺/CaMKⅡpathway as a promising therapeutic target for managing diabetes-related bone lesions, providing novel insights into the intervention strategies for metabolic bone diseases and impaired osseointegration of dental implants in diabetic patients.

Key words: Wnt/Ca²⁺/CaMKⅡ pathway, Osteogenesis, Diabetes mellitus, Bone metabolism

丁佳琪,周文娟. Wnt/ Ca²⁺/CaMKⅡ信号通路在成骨调控及糖尿病骨代谢异常中作用机制的研究进展[J]. 中国口腔种植学杂志, 2025, 30(3): 305-311. DOI: 10.12337/zgkqzzxzz.2025.06.016

Ding Jiaqi, Zhou Wenjuan. Research progress on the role and mechanism of the Wnt/Ca²⁺/CaMKⅡsignaling pathway in osteogenic regulation and diabetic bone metabolism disorders[J].Chinese Journal of Oral Implantology, 2025, 30(3): 305-311.DOI: 10.12337/zgkqzzxzz.2025.06.016.

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Wnt/ Ca²⁺/CaMKⅡ信号通路在成骨调控及糖尿病骨代谢异常中作用机制的研究进展

Research progress on the role and mechanism of the Wnt/Ca²⁺/CaMKⅡsignaling pathway in osteogenic regulation and diabetic bone metabolism disorders

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