基于微生态失调的种植体周疾病及干预策略

doi:10.12337/zgkqzzxzz.2025.06.015

中国口腔种植学杂志 ›› 2025, Vol. 30 ›› Issue (3): 296-304.DOI: 10.12337/zgkqzzxzz.2025.06.015

基于微生态失调的种植体周疾病及干预策略

陈刚^1,2, 赵鑫^1,2, 钟飞³, 顾红政³

¹镇江市口腔医院种植修复科 212003;
²镇江市口腔医院中心实验室 212003;
³镇江市口腔医院专家会诊中心 212003

收稿日期:2025-02-20 出版日期:2025-06-30 发布日期:2025-06-27
通讯作者: 顾红政,Email：jszjghz@163.com,电话：0511-85581386
作者简介:陈刚,口腔医学博士、博士后、硕士研究生导师,研究方向：口腔微生态与种植体周炎。
顾红政,主任医师、教授,研究方向：骨缺损修复及种植治疗,种植体周围疾病管理,口腔内科疾病诊疗及疑难根管治疗等
基金资助:
国家自然科学基金青年项目（81702979）; 镇江市口腔医院高层次人才科研项目（YNKY2501）

Peri-implant diseases based on microdysbiosis and intervention strategies

Chen Gang^1,2, Zhao Xin^1,2, Zhong Fei³, Gu Hongzheng³

¹Department of Implantology and Prosthetics, Zhenjiang Stomatological Hospital, Zhenjiang 212003, Zhejiang, China;
²Central Laboratory of Zhenjiang Stomatological Hospital, Zhenjiang 212003, Zhejiang, China;
³Expert Consultation Center, Zhenjiang Stomatological Hospital, Zhenjiang 212003, Zhejiang, China

Received:2025-02-20 Online:2025-06-30 Published:2025-06-27
Contact: Gu Hongzheng, Email: jszjghz@163.com, Tel: 0086-511-85581386
Supported by:
National Natural Science Foundation of China Youth Project (81702979); High-level Talent Research Project of Zhenjiang Stomatological Hospital (YNKY2501)

摘要/Abstract

摘要： 种植体周疾病是发生在种植体周软组织和硬组织的炎症,以菌斑生物膜为始动因子,主要分为种植体周黏膜炎与种植体周炎,口腔菌群失调在其中扮演重要角色,即口腔微生物群在组成和功能上发生改变。在将种植体周疾病的发病机制与微生态失调相联系的过程中,微生物组研究领域面临着诸多挑战,其需要阐明失调的微生物组结构开始产生并持续存在的相关机制,还要明确宿主与微生物组之间的因果关联,以及伴随疾病进程出现的继发性微生物变化。本文从概念层面对菌群失调进行了系统性分类,并概述各类别间的免疫学关联;进一步探讨细菌菌群失调的成因及其在种植体周疾病中的病理生理作用,同时分析了其对临床治疗策略的潜在影响。从分子层面理解口腔微生态失调的起源、其内在调控机制和环境调节因素及其下游效应,希望为开发针对种植体周疾病的微生物组靶向疗法提供有益思路,为推动种植体周疾病的精准医疗提供理论依据。

关键词: 种植体周黏膜炎, 种植体周炎, 口腔致病菌, 防治措施, 菌群失调

Abstract: Peri-implant disease is a chronic inflammation condition affecting the soft and hard tissues surrounding dental implants, primarily caused by bacterial infection. It is categorized into peri-implant mucositis and peri-implantitis. Oral microbial dysbiosis plays an important role that is characterized by alterations in microbial composition and function. In linking the pathogenesis of peri-implant diseases to microdysbiosis, current microbiome research faces several challenges: elucidating the molecular mechanisms driving the initiation and persistence of dysregulated microbiome structure, discerning causal host-microbiome relationships, and expounding secondary microbial changes during disease progression. In this review, we systematically classify dysbiosis from a conceptual perspective, outlining its immunological associations across category. We further elaborate on the causes of bacterial dysbiosis and analyze its potential impact on clinical treatment strategies. At the molecular level, understanding the origins, intrinsic regulatory mechanisms, environmental regulatory factors, and downstream effects of oral microdysbiosis may facilitate the development of microbiome-targeted therapies against peri-implant diseases. This research direction holds significant importance for promoting precision medicine in the context of peri-implant diseases.

Key words: Peri-implant mucositis, Peri-implantitis, Oral pathogenic bacteria, Prevention and control measures, Dysbiosis

陈刚,赵鑫,钟飞,等. 基于微生态失调的种植体周疾病及干预策略[J]. 中国口腔种植学杂志, 2025, 30(3): 296-304. DOI: 10.12337/zgkqzzxzz.2025.06.015

Chen Gang, Zhao Xin, Zhong Fei, Gu Hongzheng. Peri-implant diseases based on microdysbiosis and intervention strategies[J].Chinese Journal of Oral Implantology, 2025, 30(3): 296-304.DOI: 10.12337/zgkqzzxzz.2025.06.015.

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基于微生态失调的种植体周疾病及干预策略

Peri-implant diseases based on microdysbiosis and intervention strategies

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