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Table of Content

    30 April 2025, Volume 30 Issue 2
    Preface for the key column“autologous blood derivatives and dental implantation”
    Editorial Board of Chinese Journal of Oral Implantology
    2025, 30(2):  97-97.  DOI: 10.12337/zgkqzzxzz.2025.04.001
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    The application of platelet-rich fibrin in peri-implant soft tissue augmentation
    Fu Li, Zhou Yanmin
    2025, 30(2):  98-105.  DOI: 10.12337/zgkqzzxzz.2025.04.002
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    Soft tissue augmentation is an effective technique for improving both the quality and contour of peri-implant soft tissues. The selection of surgical procedures and materials has been a major focus of ongoing research. In recent years, the application of platelet-rich fibrin (PRF) in soft tissue augmentation procedures has garnered significant attention. However, there remains a lack of systematic discussion regarding its indications, application methods, and clinical outcomes. This article reviews the clinical strategies for soft tissue augmentation, and explores the mechanisms, research progress, and clinical effects related to PRF in peri-implant tissue augmentation, aiming to provide valuable insights for clinical application.
    Application of bone densification technique combined with plasma matrix in transalveolar technique for sinus floor elevation
    Wang Yulan, Zeng Hao, Xia Ting, Zhang Yufeng
    2025, 30(2):  106-110.  DOI: 10.12337/zgkqzzxzz.2025.04.003
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    The patient had been missing right maxillary posterior teeth for several months and requested implant restoration. CBCT examination revealed an alveolar bone height of less than 5 mm in the edentulous area, an inclined sinus floor morphology, and low bone density. A combination of bone densification technique and plasma matrix was used to perform transalveolar sinus floor elevation and implant placement simultaneously. No sinus membrane perforation occurred intraoperatively, and no postoperative infections or complications were observed. A six-month follow-up showed successful osseointegration, sufficient bone volume, and smooth completion of the second-stage surgery, impression-taking, and final prosthetic restoration. In this case, the bone densification technique enhanced bone density by compacting bone and elevating the sinus membrane. The plasma matrix, rich in growth factors, effectively protected the sinus membrane, reduced potential complications, and improved bone regeneration outcomes.
    Research on the utilization of sticky bone in bone regeneration
    Liang Yixin, Qu Zhe
    2025, 30(2):  111-117.  DOI: 10.12337/zgkqzzxzz.2025.04.004
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    The high concentrations of growth factors within platelets have been proven to promote cell migration, proliferation, and angiogenesis during the regeneration process. Multiple efforts have been exerted to blend them with bone substitute materials, to fabricate "sticky bone" for easier manipulation by surgeons. While autologous and allogeneic bone grafts are limited by donor site availability and biocompatibility issues, synthetic bone grafts exhibit significant advantages in terms of biocompatibility. The integration of growth factors into these porous synthetic grafts can effectively stimulate cell growth and differentiation, thereby enhancing osteogenic potential. This paper reviews the research and advancements in sticky bone for bone regeneration, elaborating on the fabrication and characterization of sticky bone materials. Moreover, it also highlights the promising outcomes and benefits of sticky bone in bone defect regeneration, substantiated by clinical data from both domestic and international studies.
    Effect of platelet-rich fibrin on bone regeneration
    Huang Lirong, Feng Zeru, Wu Hongkun, Mo Anchun
    2025, 30(2):  118-126.  DOI: 10.12337/zgkqzzxzz.2025.04.005
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    Platelet-rich fibrin (PRF), a second-generation autologous platelet concentrate, has been widely used in oral implantology and maxillofacial surgery due to its excellent biocompatibility and bone regeneration capacity. PRF facilitates osteoblast activation, angiogenesis, and bone remodeling by sustained release of growth factors through its three-dimensional fibrin network. It has shown significant potential in sinus floor elevation, bone augmentation, extraction site preservation, and immediate implant placement, improving implant stability and survival rates. Additionally, PRF has shown efficacy in the treatment of medication-related osteonecrosis of the jaw (MRONJ) by reducing infection, alleviating inflammation, and promoting tissue healing. However, PRF's clinical outcomes are influenced by individual physiological differences, preparation methods, and degradation rates. PRF's long-term osteogenic effects, especially in severe bone defects, remain inconsistent. Optimizing centrifugation parameters, blood collection tube materials, and fiber structure, as well as combining PRF with bone grafts, antimicrobial drugs, and biomimetic scaffolds, can enhance its performance. Additionally, PRF combined with nanomaterials and hydrogel scaffolds shows potential advantages in angiogenesis and tissue regeneration, though long-term follow-up data remain limited. In conclusion, PRF holds significant promise in bone regeneration. However, further studies are required to establish standardized preparation protocols and multidisciplinary strategies to improve its clinical stability and efficacy.
    Advances in the application of platelet-rich fibrin in sinus floor elevation
    Lyu Huixin, Zhou Yanmin
    2025, 30(2):  127-134.  DOI: 10.12337/zgkqzzxzz.2025.04.006
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    Sinus floor elevation is an effective procedure for addressing bone deficiency in the posterior maxillary region. To achieve an ideal three-dimensional osteogenesis model for the maxillary sinus (3D-OMMS), which involves coordinated bone formation along the maxillary sinus floor wall, Schneiderian membrane, and implant surface, improvements in surgical techniques combined with the rational use of biomaterials are required. Platelet-rich fibrin (PRF) not only releases various growth factors but also modulates local immune responses and promotes the proliferation of various cells, including stem cells. By harnessing the beneficial osteogenic potential from both the bone wound and the maxillary sinus membrane, PRF plays an active role in the 3D-OMMS. Therefore, it is recommended to use PRF in maxillary sinus floor elevation surgery. This review summarizes clinical evidence indicating that PRF alone, PRF combined with other biomaterials, and PRF utilized with the "tenting effect" of implants to elevate the Schneiderian membrane can all achieve stable outcomes in sinus floor elevation. Additionally, it offers a summary and recommendations for clinical decision-making regarding the use of PRF in sinus floor elevation procedures.
    Finite element analysis of a novel 3D-printed temporary fixed prosthesis for edentulous jaws under multidirectional loading
    Zhang Chuankai, Zhang Jiayuan, Pan Yulei, Chen Qingsheng, Lin Haiyan
    2025, 30(2):  135-143.  DOI: 10.12337/zgkqzzxzz.2025.04.007
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    Objective This study aimed to investigate the biomechanical properties of a novel 3D-printed temporary fixed denture for edentulous jaws using finite element analysis, and to compare its mechanical performance with that of conventional non-3D-printed polyetheretherketone (PEEK) and 3D-printed polylactic acid (PLA). Methods A three-dimensional finite element model of a mandible with complete edentulism was established based on a patient treated with an implant-supported temporary fixed prosthesis at Hangzhou Stomatological Hospital (Pinghai Campus) in May 2024. Three materials were analyzed: polyetheretherketone (PEEK, A1), polylactic acid (PLA, A2), and 3D-printed light-curing temporary crown and bridge resin for additive manufacturing (A3). A static load of 150 N was applied to anterior and posterior crowns and bridges in eight different directions: vertical load on posterior teeth (G1), right posterior buccal-to-lingual load (G2), right posterior lingual-to-buccal load (G3), left posterior buccal-to-lingual load (G4), left posterior lingual-to-buccal load (G5), vertical load on anterior teeth (G6), anterior labial-to-lingual load (G7), and anterior lingual-to-labial load( G8). Finite element analyses were performed using ANSYS 2021 R1 to evaluate the maximum Von Mises stress (MPa), maximum total deformation (mm), maximum Von Mises strain (mm), and stress distribution maps for each material. Results ①The maximum Von Mises stress of A1 (PEEK) was lower than A2 (PLA) in all directions, and A3 exhibited lower Von Mises stress than A2 in five directions.② A3 demonstrated lower maximum total deformation and Von Mises strain than A1 and A2 in seven directions; however, in direction G6 (vertical load on anterior teeth), A3 exhibited the largest total deformation and Von Mises strain. ③For anterior loading, the greatest deformation was concentrated at the incisal edge, with Von Mises strain evenly distributed across the anterior teeth and stress concentrated around the connector of the prosthesis.④For posterior loading, the greatest deformation was located at the distal margin of the mandibular second molar, with relatively uniform strain distribution in posterior regions, and peak stress located at the implant-abutment connection. Conclusion The novel 3D-printed temporary fixed denture for edentulous jaws demonstrated partially superior mechanical properties compared to both PEEK and PLA materials under simulated functional loading.
    Comparison of trapezoidal full-thickness flap and combination flap in guided bone regeneration in the posterior mandible
    Hu Xiucheng, Sun Shichen, Wu Binbin, Wu Dan, Sun Haipeng
    2025, 30(2):  144-150.  DOI: 10.12337/zgkqzzxzz.2025.04.008
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    Objective This study aimed to investigate the clinical advantages and disadvantages of two flap advancement techniques, trapezoidal full-thickness flap (TFF) and combination flap (CF), in guided bone regeneration (GBR) in the posterior mandible, and to compare the differences in postoperative pain and swelling levels between the two techniques. Methods A retrospective analysis was conducted on 89 patients who underwent single posterior mandibular implant placement with simultaneously guided bone regeneration in our hospital from September 2023 to May 2024. The patients were divided into two groups according to the flap advancement technique: the TFF group (47 patients) and the CF group (42 patients). The two groups were compared in terms of the need for additional vertical incisions, the use of additional fixation devices such as membrane fixation screws, and the incidence of accidental flap perforation. Postoperative pain and swelling were recorded for one week following surgery in both groups. Results During surgery, all cases in the TFF group required vertical incisions extending beyond the mucogingival junction. In the CF group, 13 cases (31.0%) did not require additional vertical incisions, and 29 cases(69.0%)required small vertical incisions terminating at the mucogingival junction. No flap perforations occurred in the TFF group, while in the CF group, there were 2 cases (4.8%) of accidental flap perforation during periosteal incision and flap release. For collagen membrane fixation, in the TFF group, 22 cases (46.8%) used membrane fixation screws at the crest, and 25 cases (53.2%) used screws at the apex; in the CF group, 18 cases (42.9%) used membrane fixation screws at the crest, but no screws were needed at the apex. No postoperative infections or bone graft material exposure were observed in either group. Although pain levels were lower in the TFF group compared to those in the CF group on postoperative days 1, 3, 5, and 7, no statistically significant difference was observed between the two groups (P>0.05). Similarly, while swelling levels were lower in the TFF group than in the CF group on postoperative days 1, 3, and 5, no statistically significant difference was found between the two groups (P>0.05). However, on postoperative day 7, swelling was significantly lower in the TFF group than in the CF group (P<0.05). Conclusion Both techniques could achieve effective flap advancement and primary wound closure following GBR procedures. There was no significant difference in postoperative pain between the two groups during the entire observation period, and no significant difference in swelling on postoperative days 1, 3, and 5, except that swelling in the CF group was slightly more severe than in the TFF group on postoperative day 7. As a modified flap advancement technique, CF is more technically sensitive than the classic TFF. However, when CF is applied in the posterior mandible, it can reduce the use of additional vertical incisions, which benefits blood supply and reduces surgical invasiveness. Additionally, it can retain the collagen membrane by using the apical periosteal "pocket", thus eliminating the use of membrane fixation screws at the apex of the surgical area and decreasing the risk of damaging adjacent anatomical structures. Therefore, the combination flap technique has good clinical applicability and potential for widespread adoption.
    Retrospective study on the prevalence and risk factors of proximal contact loss between implant-supported fixed restorations and adjacent natural teeth
    Niu Yimeng, Zhong Weijian
    2025, 30(2):  151-160.  DOI: 10.12337/zgkqzzxzz.2025.04.009
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    Objective This study aimed to observe the incidence of proximal contact loss (PCL) between implant-supported fixed prostheses and adjacent natural teeth in the posterior region and to analyze the risk factors. Methods A total of 103 patients who underwent ISFPs placement in the posterior regions were enrolled in this study, comprising 226 implants and 233 interproximal contact points. A 50 μm metal shim and dental floss were used to assess proximal contact tightness. Kaplan-Meier analysis, univariate log-rank test, multivariate Cox regression analysis, and Spearman rank correlation analysis were used to evaluate the association of patient characteristics, implant location, adjacent tooth bone support level, and opposing dentition status with PCL occurrence. Results The incidence of PCL was 68.0% at the patient level and 36.9% at the contact site level. The incidence of mesial PCL (46.6%) was significantly higher than that of distal PCL (15.3%). Multivariate Cox regression analysis showed that food impaction, marginal ridge height discrepancy, peri-implantitis, gingival inflammation, and an adjacent tooth bone support level >3/8 were independent risk factors for PCL. Kaplan-Meier analysis showed a progressive increase in PCL incidence over time, reaching 50.0% at the contact site level at the 6-year follow-up. Spearman rank correlation analysis showed that there was a positive correlation between the gap size of PCL and follow-up duration (rs=0.303). The mean PCL gap size was about 0.239 mm, and the maximum value was 0.800 mm. Conclusion This study found that food impaction was one of the most significant risk factors for PCL, although a bidirectional causal relationship may exist between the two. Over time, both PCL incidence and gap size increased progressively. Clinically, regular follow-up visits after implant placement are recommended to monitor and manage PCL. Risk-based interventions, including occlusal adjustment, restorative modifications, or crown replacement, may help prevent and treat PCL effectively.
    Comprehensive sequential treatment of peri-implantitis based on etiological analysis: a case report
    Yang Rui, Xu Zhijie
    2025, 30(2):  161-168.  DOI: 10.12337/zgkqzzxzz.2025.04.010
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    Peri-implantitis is an inflammatory disease of the peri-implant soft and hard tissues, primarily caused by plaque biofilms and influenced by multiple factors. This article presents the comprehensive sequential treatment process and follow-up results of a patient with peri-implantitis and discusses the optimal treatment approach. In this case, the implant prosthesis was first removed for non-surgical treatment to preliminarily control the infection, followed by bone regenerative surgery to reconstruct peri-implant bone tissue. Subsequently, free gingival grafting was performed to improve peri-implant soft tissue conditions, and the prosthesis morphology was adjusted and reinserted. Throughout the treatment and follow-up periods, both self-maintenance and professional maintenance were emphasized. After a 2-year follow-up, the peri-implant gingival redness, swelling, and suppuration subsided, the deep periodontal pockets resolved, and alveolar bone regeneration was achieved and maintained, resulting in a satisfactory therapeutic outcome.
    Advances in basic and clinical research on the socket-shield technique
    Feng Shenghui, Pan Xiaobo, Tang Zengbin, Long Xiaojie, Yang Yujie
    2025, 30(2):  169-175.  DOI: 10.12337/zgkqzzxzz.2025.04.011
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    Achieving predictable aesthetic outcomes in implant restoration of the anterior zone remains a major challenge, particularly in preserving and reconstructing the peri-implant soft and hard tissues to ensure harmony with adjacent teeth. The socket-shield technique (SST) effectively maintains the alveolar ridge contour and reduces soft tissue collapse by preserving the biological integrity of the bundled bone-periodontal ligament complex. This technique enhances the aesthetic outcomes of implant therapy. This article summarizes and discusses the background, evidence-based support, clinical applications, and prognosis of SST, aiming to provide a reference for clinical dentists performing anterior implant restoration.
    Research progress on the effects of osteoblast/osteoclast axis on bone metabolism in diabetes mellitus
    Wang Ziyang, Ma Xudong
    2025, 30(2):  176-179.  DOI: 10.12337/zgkqzzxzz.2025.04.012
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    The osteoblast/osteoclast axis is a key regulatory system in bone metabolism, in which osteoblasts and osteoclasts interact and regulate each other through multiple signaling pathways to maintain skeletal homeostasis. Diabetes mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, leading to impaired osseointegration and reduced success rates of implant therapy. This paper reviews the biological role of the osteoblast/osteoclast axis and the impact of diabetes mellitus on its regulation. It also discusses potential strategies for modulating this axis to enhance osseointegration in diabetic patients and improve the clinical success of implant treatment.
    Research progress and clinical application of dental implant macro-design
    Cai Wenyu, Ma Junchi, Zhao Wenbo, Wang Yiming, Zhou Libo
    2025, 30(2):  180-186.  DOI: 10.12337/zgkqzzxzz.2025.04.013
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    In recent years, the design of implant configurations has been continuously optimized, playing a key role in improving initial stability and promoting osseointegration, which are key factors for achieving long-term functional stability of implants. However, there is still no unified consensus on the optimal implant configuration. This article explores various aspects of implant design, including the neck structure, thread pattern, overall shape, apex features, diameter, and length, with different bone qualities and clinical conditions, such as immediate and delayed implantation, as well as anterior and posterior implantation sites. By summarizing the most favorable implant configurations identified in current research, this review aims to provide a reference for clinical applications.
    Research progress on the bone window in lateral window technique for sinus floor elevation
    Zhang Heng, Zhou Yiqun
    2025, 30(2):  187-192.  DOI: 10.12337/zgkqzzxzz.2025.04.014
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    The lateral window technique for sinus floor elevation is a key approach to address insufficient alveolar bone height in posterior maxillary implant surgery, and research in this area has been continuously advancing. With ongoing improvements in bone window design and the application of digital technology, significant progress has been made in reducing intraoperative complications, minimizing postoperative trauma, enhancing osteogenesis, and increasing implant survival rates. This review summarizes the design aspects of the bone window, including its shape, size, and position, as well as the application of digital technology in the lateral window technique for sinus floor elevation, aiming to provide a reference for bone window selection in this surgical procedure.
    Evaluation of a virtual simulation training system in the teaching of lateral window technique for sinus floor elevation
    Zhang Min, You Lang, Lei Jingshi, Wang Fang, Fan Zhen
    2025, 30(2):  193-197.  DOI: 10.12337/zgkqzzxzz.2025.04.015
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    Objective To explore the application of a virtual simulation training system in the teaching of lateral window technique for sinus floor elevation for undergraduate dental students. Methods Sixty fourth-year undergraduate students from the School of Stomatology, Tongji University, were recruited between January 2023 and June 2024 and randomly assigned to either the traditional teaching group or the virtual simulation teaching group. The traditional teaching group received instruction through multimedia presentations and instructional videos, whereas the virtual simulation teaching group utilized a self-developed virtual simulation training system. Both groups underwent assessments of theoretical knowledge and clinical skills. A survey questionnaire was administered to evaluate teaching effectiveness. Results The students in the virtual simulation teaching group achieved significantly higher scores in both the theoretical examination and clinical skills assessment compared to those in the traditional teaching group (P<0.05). The survey results indicated that the virtual simulation-based course was superior in increasing students' learning interests and capabilities, improving clinical skills and critical thinking, and enhancing self-confidence compared to the traditional teaching method. Conclusion The implementation of the virtual simulation training system significantly improves undergraduate dental students' understanding of theoretical knowledge and proficiency in clinical skills related to lateral window technique for sinus floor elevation. Additionally, it enhances students' learning motivation and self-confidence, making it an effective educational approach.