种植体骨结合过程中免疫细胞作用的研究进展

doi:10.12337/zgkqzzxzz.2021.06.010

中国口腔种植学杂志 ›› 2021, Vol. 26 ›› Issue (3): 196-201.DOI: 10.12337/zgkqzzxzz.2021.06.010

种植体骨结合过程中免疫细胞作用的研究进展

李效宇, 蔡青, 尹昭懿, 金卓华, 王子璇, 孟维艳

吉林大学口腔医院口腔种植中心吉林省牙发育及颌骨重塑与再生重点实验室,长春 130021

收稿日期:2021-01-07 出版日期:2021-06-10 发布日期:2021-07-14
通讯作者: 孟维艳,Email：mengwy@jlu.edu.cn,电话：0433-88796025
作者简介:李效宇, 在读硕士研究生,研究方向：口腔种植学相关研究;孟维艳, 主任医师、教授、博士研究生导师,研究方向：口腔种植学相关研究
基金资助:
吉林省科学技术厅科技发展计划项目(20200404108YY); 吉林省财政厅科技项目(JCSZ2019378-3); 吉林省发展改革委员会(JCSZ2020304-1)

Research progress of immune cells in the process osseointegration

Li Xiaoyu, Cai Qing, Yin Zhaoyi, Jin Zhuohua, Wang Zixuan, Meng Weiyan

Department of dental Implantology, Hospital of Stomatology, Jilin University&Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China

Received:2021-01-07 Online:2021-06-10 Published:2021-07-14
Contact: Meng Weiyan, Email: mengwy@jlu.edu.cn,Tel: 0086-433-88796025
Supported by:
Science and Technology Development Plan of Science and Technology Department of Jilin Province(20200404108YY)；Science and Technology Projects of Finance Department of Jilin Province(JCSZ2019378-3); Jilin Provincial Development and Reform Commission(JCSZ2020304-1)

摘要/Abstract

摘要： 良好的骨结合是决定种植成功率和种植体远期留存率的关键。在形成骨结合的过程中,免疫细胞可通过清除种植术区组织碎片及病原菌,调节炎症反应程度,诱导间充质干细胞募集和成骨分化等,在改善局部成骨微环境及形成新生骨等方面发挥重要功能。为设计更好的免疫调节策略以在种植体周形成良好的骨结合,本文将针对不同免疫细胞在骨结合过程中发挥的具体作用及如何实现对其功能的调节作一综述。

关键词: 口腔种植, 骨结合, 中性粒细胞, 巨噬细胞, 间充质干细胞, 骨生物材料

Abstract: High-quality osseointegration is the key to the success rate and long-term survival rate of implants. Immune cells could remove the tissue fragment and pathogen, regulate the inflammatory reaction, induce the recruitment of mesenchymal stem cells and osteogenic differentiation, etc., which could improve the osteogenic microenvironment and play an essential role in the process of implant osseointegration. In order to optimize the strategy of immune regulation for forming better implant osseointegration, this article will review the specific functions of different immune cells in the process of implant osseointegration.

Key words: Dental implants, Osseointegration, Neutrophils, Macrophage, Mesenchymal stem cells, Bone biomaterial

李效宇,蔡青,尹昭懿,等. 种植体骨结合过程中免疫细胞作用的研究进展[J]. 中国口腔种植学杂志, 2021, 26(3): 196-201. DOI: 10.12337/zgkqzzxzz.2021.06.010

Li Xiaoyu, Cai Qing, Yin Zhaoyi, Jin Zhuohua, Wang Zixuan, Meng Weiyan. Research progress of immune cells in the process osseointegration[J].Chinese Journal of Oral Implantology, 2021, 26(3): 196-201.DOI: 10.12337/zgkqzzxzz.2021.06.010.

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种植体骨结合过程中免疫细胞作用的研究进展

Research progress of immune cells in the process osseointegration

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