Research progress on nano-silver antibacterial materials in the application in oral implantology

doi:10.12337/zgkqzzxzz.2023.02.008

Abstract

Abstract: As a new type of highly effective nanometer antibacterial material, nano-silver has a broad-spectrum antibacterial ability, high antibacterial efficiency, and good anti-inflammatory properties. At present, it is widely used in various fields of stomatology. The antibacterial mechanism and application of nano-silver was reviewed for the field of oral implantology, and the antibacterial research prospect of nano-silver were forecasted.

Key words: Silver nanoparticles (AgNPs), Dental implant, Antibacterial property

Cheng Wen, Ma Xiaoting, Shen Yajie, Lv Shouyin, Shao Bo. Research progress on nano-silver antibacterial materials in the application in oral implantology[J]. Chinese Journal of Oral Implantology, 2023, 28(1): 40-46.

References

[1] Hasanoglu Erbasar GN, Hocaoğlu TP, Erbasar RC.Risk factors associated with short dental implant success: a long-term retrospective evaluation of patients followed up for up to 9 years[J]. Braz Oral Res, 2019,33:e030. DOI: 10.1590/1807-3107bor-2019.vol33.0030.
[2] Pye AD, Lockhart DE, Dawson MP, et al.A review of dental implants and infection[J]. J Hosp Infect, 2009,72(2):104-110. DOI: 10.1016/j.jhin.2009.02.010.
[3] Tan WC, Ong M, Han J, et al.Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy-a multicenter randomized controlled clinical trial[J]. Clin Oral Implants Res, 2014,25(2):185-193. DOI: 10.1111/clr.12098.
[4] Rodríguez Sánchez F, Arteagoitia I, Rodríguez Andrés C, et al.Antibiotic prophylaxis prescribing habits in oral implant surgery in the Netherlands: a cross-sectional survey[J]. BMC Oral Health, 2019,19(1):281. DOI: 10.1186/s12903-019-0981-4.
[5] Ayatollahi Mousavi SA, Salari S, Hadizadeh S.Evaluation of antifungal effect of silver nanoparticles against microsporum canis, trichophyton mentagrophytes and microsporum gypseum[J]. Iran J Biotechnol, 2015,13(4):38-42. DOI: 10.15171/ijb.1302.
[6] 王孟珍, 孙昊宇, 龙茜, 等. 纳米银复合材料与抗生素的联合抗菌性能及相关机制研究[J].生态毒理学报,2020, 15(2):39-49. DOI: 10.7524/AJE.1673-5897.20191204001.
[7] Zheng Z, Yin W, Zara JN, et al.The use of BMP-2 coupled-nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects[J]. Biomaterials, 2010,31(35):9293-9300. DOI: 10.1016/j.biomaterials.2010.08.041.
[8] 刘丹, 任彪, 程磊. 纳米银在口腔感染性疾病防治中的研究进展[J].国际口腔医学杂志,2018,45(4):408-413. DOI: 10.7518/gjkq.2018.04.007.
[9] John G, Becker J, Schwarz F.Effectivity of air-abrasive powder based on glycine and tricalcium phosphate in removal of initial biofilm on titanium and zirconium oxide surfaces in an ex vivo model[J]. Clin Oral Investig, 2016,20(4):711-719. DOI: 10.1007/s00784-015-1571-8.
[10] 杨玉琼, 孟翔峰. 自酸蚀树脂粘接剂合成纳米银对唾液生物膜抗菌性的初步研究[J].东南国防医药,2020,22(4):346-350. DOI: 10.3969/j.issn.1672-271X.2020.04.003.
[11] Kielbassa AM, Leimer MR, Hartmann J, et al.Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin[J]. PLoS One, 2020,15(1):e0228249. DOI: 10.1371/journal.pone.0228249.
[12] 贾傲. 正畸粘接剂添加无定形纳米磷酸钙-多巴胺-纳米银后粘接强度和抗菌性能的研究[D].南昌大学,2022.
[13] Sawan NM,AlSagob EI,Ben GAA,et al. Graphene functionalized with nanosilver particle‐modified methacrylate‐based bonding agent improves antimicrobial capacity and mechanical strength at tooth orthodontic bracket interface[J]. Polymer Composites,2021,42(11):5850-5858.
[14] Al-Thomali Y.Shear bond strength of orthodontic brackets after adding silver nanoparticles to a nano-bond adhesive at different thermal cycles and cyclic loading-an in vitro study[J]. J Orthod Sci, 2022,11:28. DOI: 10.4103/jos.jos_183_21.
[15] Afkhami F, Rostami G, Batebi S, et al.Residual antibacterial effects of a mixture of silver nanoparticles/calcium hydroxide and other root canal medicaments against Enterococcus faecalis[J]. J Dent Sci, 2022,17(3):1260-1265. DOI: 10.1016/j.jds.2021.11.013.
[16] 姚丽萍, 张蕾, 林玉红, 等. 纳米银溶液用于慢性根尖周炎根管内封药的实验动物研究[J].中华口腔医学研究杂志(电子版),2020,14(2):95-100. DOI: 10.3877/cma.j.issn.1674-1366.2020.02.006.
[17] 吴雨峰, 王刚, 李思, 等. 钛种植体载银对牙龈卟啉单胞菌抗菌效应研究[J].安徽医科大学学报,2021,56(4):587-591. DOI: 10.19405/j.cnki.issn1000-1492.2021.04.016.
[18] Baker C, Pradhan A, Pakstis L, et al.Synthesis and antibacterial properties of silver nanoparticles[J]. J Nanosci Nanotechnol, 2005,5(2):244-249. DOI: 10.1166/jnn.2005.034.
[19] Arokiyaraj S, Vincent S, Saravanan M, et al.Green synthesis of silver nanoparticles using rheum palmatum root extract and their antibacterial activity against staphylococcus aureus and pseudomonas aeruginosa[J]. Artif Cells Nanomed Biotechnol, 2017,45(2):372-379. DOI: 10.3109/21691401.2016.1160403.
[20] Hsueh YH, Lin KS, Ke WJ, et al.The antimicrobial properties of silver nanoparticles in bacillus subtilis are mediated by released Ag+ ions[J]. PLoS One. 2015,10(12):e0144306. DOI: 10.1371/journal.pone.0144306.
[21] Ma S, Zhan S, Jia Y, et al.Highly efficient antibacterial and Pb(II) removal effects of Ag-CoFe₂O₄-GO nanocomposite[J]. ACS Appl Mater Interfaces, 2015,7(19):10576-10586. DOI: 10.1021/acsami.5b02209.
[22] Tang S, Zheng J.Antibacterial activity of silver nanoparticles: structural effects[J]. Adv Healthc Mater, 2018,7(13):e1701503. DOI: 10.1002/adhm.201701503.
[23] Liao C, Li Y, Tjong SC.Bactericidal and cytotoxic properties of silver nanoparticles[J]. Int J Mol Sci, 2019,20(2):449. DOI: 10.3390/ijms20020449.
[24] Morones JR, Elechiguerra JL, Camacho A, et al.The bactericidal effect of silver nanoparticles[J]. Nanotechnology, 2005,16(10):2346-2353. DOI: 10.1088/0957-4484/16/10/059.
[25] Kim JS, Kuk E, Yu KN, et al.Antimicrobial effects of silver nanoparticles[J]. Nanomedicine, 2007,3(1):95-101. DOI: 10.1016/j.nano.2006.12.001.
[26] van den Brule S, Ambroise J, Lecloux H, et al. Dietary silver nanoparticles can disturb the gut microbiota in mice[J]. Part Fibre Toxicol, 2016,13(1):38. DOI: 10.1186/s12989-016-0149-1.
[27] Choi O, Deng KK, Kim NJ, et al.The inhibitory effects of silver nanoparticles, silver ions, and silver chloride colloids on microbial growth[J]. Water Res, 2008,42(12):3066-3074. DOI: 10.1016/j.watres.2008.02.021.
[28] Barhoum A, Rehan M, Rahier H, et al.Seed-mediated hot-injection synthesis of tiny Ag nanocrystals on nanoscale solid supports and reaction mechanism[J]. ACS Appl Mater Interfaces, 2016,8(16):10551-10561. DOI: 10.1021/acsami.5b10405.
[29] Franci G, Falanga A, Galdiero S,et al.Silver nanoparticles as potential antibacterial agents[J]. Molecules. 2015,20(5):8856-8874. DOI: 10.3390/molecules20058856.
[30] Sondi I, Salopek-Sondi B.Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for gram-negative bacteria[J]. J Colloid Interface Sci, 2004,275(1):177-182. DOI: 10.1016/j.jcis.2004.02.012.
[31] Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L, et al.Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria[J]. World Journal of Microbiology and Biotechnology 2010, 26:615-621.DOI: 10.1007/s11274-009-0211-3.
[32] Martinez-Castanon GA,Nino-Martinez N,Martinez-Gutierrez F,et al.Synthesis and antibacterial activity of silver nanoparticles with different sizes[J]. J Nanopart Res.2008, 10:1343-1348.DOI:10.1007/s11051-008-9428-6.
[33] Pal S, Tak YK, Song JM.Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the gram-negative bacterium escherichia coli[J]. Appl Environ Microbiol, 2007,73(6):1712-1720. DOI: 10.1128/AEM.02218-06.
[34] Moldovan B, David L, Vulcu A, et al.In vitro and in vivo anti-inflammatory properties of green synthesized silver nanoparticles using viburnum opulus L. fruits extract[J]. Mater Sci Eng C Mater Biol Appl, 2017,79:720-727. DOI: 10.1016/j.msec.2017.05.122.
[35] Nadworny PL, Wang J, Tredget EE, et al.Anti-inflammatory activity of nanocrystalline silver-derived solutions in porcine contact dermatitis[J]. J Inflamm (Lond), 2010,7:13. DOI: 10.1186/1476-9255-7-13.
[36] Alkhalaf MI, Hussein RH, Hamza A.Green synthesis of silver nanoparticles by nigella sativa extract alleviates diabetic neuropathy through anti-inflammatory and antioxidant effects[J]. Saudi J Biol Sci, 2020,27(9):2410-2419. DOI: 10.1016/j.sjbs.2020.05.005.
[37] Dong Y, Ye H, Liu Y, et al.pH dependent silver nanoparticles releasing titanium implant: a novel therapeutic approach to control peri-implant infection[J]. Colloids Surf B Biointerfaces, 2017,158:127-136. DOI: 10.1016/j.colsurfb.2017.06.034.
[38] Gorzelanny C, Kmeth R, Obermeier A, et al.Silver nanoparticle-enriched diamond-like carbon implant modification as a mammalian cell compatible surface with antimicrobial properties[J]. Sci Rep, 2016,6:22849. DOI: 10.1038/srep22849.
[39] 袁博, 张娜, 景明. MTT法和LDH法评价纳米银抗菌凝胶的体外细胞毒性[J].中国医疗器械信息,2022,28(23): 24-26,31. DOI: 10.3969/j.issn.1006-6586.2022.23.007.
[40] Sapkota K,Narayanan K B, Han S S.Environmentally sustainable synthesis of catalytically-active silver nanoparticles and their cytotoxiceffect on human keratinocytes[J]. Journal of Cluster Science, 2017,28:1605-1616. DOI: 10.1007/s10876-017-1169-1.
[41] 汤京龙, 王硕, 刘丽, 等. 纳米银颗粒的细胞毒性作用及机制初探[J].北京生物医学工程,2013,32(5):485-489. DOI: 10.3969/j.issn.1002-3208.2013.05.08.
[42] Liu M, Liu T, Chen X, et al.Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing[J]. J Nanobiotechnology, 2018,16(1):89. DOI: 10.1186/s12951-018-0416-4.
[43] Karlsson HL, Gustafsson J, Cronholm P, et al.Size-dependent toxicity of metal oxide particles--a comparison between nano-and micrometer size[J]. Toxicol Lett, 2009,188(2):112-118. DOI: 10.1016/j.toxlet.2009.03.014.
[44] Huk A, Izak-Nau E, Reidy B, et al.Is the toxic potential of nanosilver dependent on its size?[J]. Part Fibre Toxicol, 2014,11:65. DOI: 10.1186/s12989-014-0065-1.
[45] Wan Y, Xu W, Ren X, et al.Microporous frameworks as promising platforms for antibacterial strategies against oral diseases[J]. Front Bioeng Biotechnol, 2020,8:628. DOI: 10.3389/fbioe.2020.00628.
[46] 谢琳, 曹佾熙, 夏怡安, 等. 口腔种植体周围菌群分布的研究进展[J].暨南大学学报(自然科学与医学版) ,2022,43(4):419-424. DOI: 10.11778/j.jdxb.20220091.
[47] Cao H, Liu X, Meng F, et al.Biological actions of silver nanoparticles embedded in titanium controlled by micro-galvanic effects[J]. Biomaterials, 2011,32(3):693-705. DOI: 10.1016/j.biomaterials.2010.09.066.
[48] Flores CY, Diaz C, Rubert A, et al.Spontaneous adsorption of silver nanoparticles on Ti/TiO2 surfaces. Antibacterial effect on Pseudomonas aeruginosa[J]. J Colloid Interface Sci, 2010,350(2):402-408. DOI: 10.1016/j.jcis.2010.06.052.
[49] Zheng Y, Li J, Liu X, et al.Antimicrobial and osteo-genic effect of Ag-implanted titanium with a nano-structured surface[J]. Int J Nanomedicine, 2012, 7:875-884.DOI: org/10.2147/IJN.S28450.
[50] 李小军, 章燕珍, 张小萍, 等. 纳米银粒子涂层种植体在防治兔种植体周围炎中的应用研究[J].中华危重症医学杂志(电子版), 2018,11(2):130-132. DOI: 10.3877/cma.j.issn.1674-6880.2018.02.013.
[51] Orsini G, Fanali S, Scarano A, et al.Tissue reactions, fluids, and bacterial infiltration in implants retrieved at autopsy: a case report[J]. Int J Oral Maxillofac Implants, 2000,15(2):283-286.
[52] Bergamo A, Nelson-Filho P, Andrucioli M, et al.Microbial complexes levels in conventional and self-ligating brackets[J]. Clin Oral Investig, 2017,21(4):1037-1046. DOI: 10.1007/s00784-016-1865-5.
[53] Nascimento CD, Pita MS, Fernandes F, et al.Bacterial adhesion on the titanium and zirconia abutment surfaces[J]. Clin Oral Implants Res, 2014,25(3):337-343. DOI: 10.1111/clr.12093.
[54] Fernandes PF, Grenho L, Fernandes MH, et al.Microgap and bacterial microleakage during the osseointegration period: an in vitro assessment of the cover screw and healing abutment in a platform-switched implant system[J]. J Prosthet Dent, 2021,1-9. DOI:10.1016/j.prosdent.2021.07.030.
[55] Matsubara VH, Igai F, Tamaki R, et al.Use of silver nanoparticles reduces internal contamination of external hexagon implants by candida albicans[J]. Braz Dent J, 2015,26(5):458-462. DOI: 10.1590/0103-644020130087.
[56] Odatsu T, Kuroshima S, Sato M, et al.Antibacterial properties of nano-Ag coating on healing abutment: an in vitro and clinical study[J]. Antibiotics (Basel), 2020,9(6):347. DOI: 10.3390/antibiotics9060347.
[57] 刘泉, 黄文, 韦柳华, 等. 纳米银涂层基台在种植牙中应用研究[J].现代口腔医学杂志,2017,31(5):277-280.
[58] Gama-Lara SA, Pérez Mendoza MS, Vilchis-Nestor AR, et al.Bionanotechnology: silver nanoparticles supported on bovine bone powder used as bactericide[J]. Materials (Basel), 2020,13(2):462. DOI: 10.3390/ma13020462.
[59] 郑宇, 李冰婷, 王俐杰, 等. 纳米银与纳米羟基磷灰石混合填塞对即刻种植骨结合的作用[J].中国组织工程研究, 2015,(47):7649-7654. DOI: 10.3969/j.issn.2095-4344.2015.47.019.
[60] 周璞. 负载纳米银的海藻酸钠细菌纤维素抗菌复合膜的制备及其性能研究[D].安徽医科大学,2021.
[61] Chen P, Wu Z, Leung A, et al.Fabrication of a silver nanoparticle-coated collagen membrane with anti-bacterial and anti-inflammatory activities for guided bone regeneration[J]. Biomed Mater, 2018,13(6):065014. DOI: 10.1088/1748-605X/aae15b.