3D打印个性化钛网用于修复严重牙槽骨缺损的临床效果——一项回顾性病例系列研究

doi:10.12337/zgkqzzxzz.2025.02.006

中国口腔种植学杂志 ›› 2025, Vol. 30 ›› Issue (1): 27-34.DOI: 10.12337/zgkqzzxzz.2025.02.006

• “3D 打印个性化钛网”重点栏目 • 上一篇下一篇

3D打印个性化钛网用于修复严重牙槽骨缺损的临床效果——一项回顾性病例系列研究

熊振杰¹, 魏永祥¹, 刘倩^2,3,4, 陈雅馨¹, 郭雪琪¹, 季若桐¹, 苏汉福¹, 邹耀堃¹, 王丽萍¹

¹广州医科大学附属口腔医院种植科广东省口腔组织修复与重建工程技术研究中心广州市口腔再生医学基础与应用研究重点实验室 510182;
²吉林大学口腔医学院,长春 130021;
³北京瑞城口腔医院100032;
⁴北京卡尔斯医疗器械有限公司 102600

收稿日期:2024-11-10 出版日期:2025-02-28 发布日期:2025-02-24
通讯作者: 王丽萍,Email：wanglplj@126.com,电话：020-81261560
基金资助:
2024年校（院）企联合资助项目（SL2023A03J00273）; 中国牙病防治基金会口腔种植科学研究专项基金（COHF ZZZX202403）

Clinical outcomes of 3D printing individualized titanium mesh for severe alveolar bone defects: a retrospective series

Xiong Zhenjie¹, Wei Yongxiang¹, Liu Qian^2,3,4, Chen Yaxin¹, Guo Xueqi¹, Ji Ruotong¹, Su Hanfu¹, Zou Yaokun¹, Wang Liping¹

¹Department of Dental Implantology, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou 510182, Guangdong, China;
²School and Hospital of Stomatology, Jilin University,Changchun 130021,China;
³Beijing Citident Hospital of Stomatology, Beijing 100032, China;
⁴Beijing CRS Medical Device Co., Ltd, Beijing 102600, China

Received:2024-11-10 Online:2025-02-28 Published:2025-02-24
Contact: Wang Liping, Email: wanglplj@126.com, Tel: 0086-20-81261560
Supported by:
The School (College) -Enterprise Co-Financed Project of 2024 (SL2023A03J00273); Scientific Research Projects for Oral Implantology of China Oral Health Foundation (COHF ZZZX202403)

摘要/Abstract

摘要： 目的分析探究3D打印个性化钛网（3D-printing individualized titanium mesh,3D-PITM）用于修复严重牙槽骨缺损的临床效果及精度。方法本研究选取了2020年2月起在广州医科大学附属口腔医院接受3D-PITM联合引导骨再生的30例患者作为研究对象。患者均签署了知情同意书,并接受了手术及术后定期随访。通过3D打印技术制备个性化钛网,并在术前进行虚拟设计和规划;术后对患者进行6~8个月的随访,收集并分析患者的临床效果、二维及三维影像学数据。结果在30例患者中,共计4例患者出现钛网暴露,发生率为13.33%（95%CI：4.30%~22.36%）,但所有患者术后均未并发感染。术后6~8个月的随访期内,种植位点在水平向及垂直向上均获得了较为理想的骨增量效果。影像学测量结果显示,与术前相比,术后6~8个月的牙槽骨宽度和高度均有显著增加（P<0.05）;术后骨增量体积与术前相比也具有统计学差异（P<0.05）。此外,与术前虚拟规划相比,术后即刻及术后6~8个月的牙槽骨变化未见明显统计学差异,表明3D-PITM可有效实现骨增量效果的可预期性。结论 3D-PITM能有效支撑骨再生,与缺损部位高度匹配,确保了新骨稳定性和效果。3D-PITM技术在修复严重牙槽骨缺损中精度较高,虽可能出现钛网暴露等并发症,但适当处理可不影响后期修复效果。因此,3D-PITM在复杂牙槽骨缺损修复中具有临床应用价值,能提供可靠的术后效果预测和手术方案优化。

关键词: 3D打印个性化钛网, 骨缺损, 引导骨再生, 骨增量

Abstract: Objective To analyze the clinical outcomes and accuracy of 3D printing individualized titanium mesh (3D-PITM) in the treatment of severe alveolar bone defects. Methods This study involved 30 patients who underwent 3D-PITM supported guided bone regeneration (3D-PITMs GBR) at the Affiliated Stomatological Hospital of Guangzhou Medical University starting in February 2020. All patients signed informed consent and underwent surgery followed by regular postoperative follow-up. Individualized titanium meshes were fabricated using 3D printing technology, with preoperative virtual design and planning. Patients were followed for 6 to 8 months postoperatively, and clinical outcomes, as well as two-dimensional (2D) and three-dimensional (3D) imaging data, were collected and analyzed. Results Among the 30 patients, 4 experienced titanium mesh exposure, yielding an incidence rate of 13.33% (95% CI: 4.30%~22.36%). However, none of the patients experienced postoperative infections. During the 6-to 8-month follow-up period, implant sites achieved satisfactory bone augmentation in both horizontal and vertical dimensions. Imaging measurements revealed significant increases in alveolar bone width and height at 6 to 8 months postoperatively compared to preoperative values (P<0.05). Postoperative bone augmentation volume also demonstrated significant improvement (P<0.05). Furthermore, there were no statistically significant differences in alveolar bone changes between preoperative virtual planning and postoperative measurements (immediate and at 6 to 8 months) , indicating that 3D-PITM provides predictable bone augmentation outcomes. Conclusion 3D printing individualized titanium mesh effectively supports bone regeneration, achieves a high degree of matching with the defect site, and ensures the stability and effectiveness of newly formed bone. The 3D-PITM technique demonstrates high precision in restoring severe alveolar bone defects. Although complications such as titanium mesh exposure may occur, appropriate management can prevent the adverse impact on subsequent restoration outcomes. 3D-PITM is clinically valuable for restoring complex alveolar bone defects, providing reliable postoperative predictions and optimizing surgical planning.

Key words: 3D printing individualized titanium mesh, Bone defect, Guided bone regeneration, Bone augmentation

熊振杰,魏永祥,刘倩,等. 3D打印个性化钛网用于修复严重牙槽骨缺损的临床效果——一项回顾性病例系列研究[J]. 中国口腔种植学杂志, 2025, 30(1): 27-34. DOI: 10.12337/zgkqzzxzz.2025.02.006

Xiong Zhenjie, Wei Yongxiang, Liu Qian, Chen Yaxin, Guo Xueqi, Ji Ruotong, Su Hanfu, Zou Yaokun, Wang Liping. Clinical outcomes of 3D printing individualized titanium mesh for severe alveolar bone defects: a retrospective series[J].Chinese Journal of Oral Implantology, 2025, 30(1): 27-34.DOI: 10.12337/zgkqzzxzz.2025.02.006.

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3D打印个性化钛网用于修复严重牙槽骨缺损的临床效果——一项回顾性病例系列研究

Clinical outcomes of 3D printing individualized titanium mesh for severe alveolar bone defects: a retrospective series

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