自体血小板浓缩物用于上颌窦底提升的系统评价再评价

doi:10.12337/zgkqzzxzz.2023.04.006

中国口腔种植学杂志 ›› 2023, Vol. 28 ›› Issue (2): 102-108.DOI: 10.12337/zgkqzzxzz.2023.04.006

自体血小板浓缩物用于上颌窦底提升的系统评价再评价

龚佳明^1,3, 赵瑞敏^1,3, 张启航², 余占海², 苏琳涵¹

¹解放军联勤保障部队第940医院口腔科,兰州 730050;
²兰州大学口腔医学院/口腔医院 730000;
³温州医科大学附属衢州医院（衢州市人民医院） 324002

收稿日期:2022-11-24 出版日期:2023-04-30 发布日期:2023-05-04
通讯作者: 苏琳涵,Email：14917731@qq.com,电话：0931-8994810
作者简介:龚佳明,硕士、医师,研究方向：口腔种植学和循证医学;苏琳涵,硕士、主治医师,研究方向：口腔修复学和口腔种植学
基金资助:
甘肃省自然科学基金（21JR11RA006）

The autologous platelet concentrates for maxillary sinus floor elevation: an overview of systematic reviews

Gong Jiaming^1,3, Zhao Ruimin¹, Zhang Qihang², Yu Zhanhai², Su Linhan¹

¹Department of Stomatology, The 940th Hospital of Joint Logistics Support Force of People's Liberation Army, Lanzhou 730050, China;
²Department of Oral Implant, School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, China;
³Department of Stomatology, Quzhou Hospital Affiliated to Wenzhou Medical University (Quzhou People's Hospital), Quzhou 324002, Zhejiang, China

Received:2022-11-24 Online:2023-04-30 Published:2023-05-04
Contact: Su Linhan, Email: 14917731@qq.com, Tel: 0086-931-8994810
Supported by:
Natural Science Foundation of Gansu Province (21JR11RA006）

摘要/Abstract

摘要： 目的评价自体血小板浓缩物（autologous platelet concentrates,APC）用于上颌窦底提升的系统评价/Meta分析（SR/MA）的方法学质量和证据质量。方法计算机检索PubMed、Embase、Cochrane Library、Scopus、CNKI、SinoMed、WanFang数据库,检索APC用于上颌窦底提升的SR/MA,检索时限均为建库至2022年8月31日。由2名审查员独立筛选文献、提取资料后,采用AMSTAR 2和GRADE系统分别对纳入研究的方法学质量和相关结局指标的证据质量进行评估。结果共纳入13篇SR/MA,其主要结论为APC用于上颌窦底提升的积极作用有限,对窦底组织愈合可能有促进作用。AMSTAR 2 评价结果显示有9个条目报告为完整,2个项目未报告,总体质量较高;GRADE对46个结局指标进行证据等级划分,其中9个为高级,25个为中级,11个为低级,1个为极低。结论当前多数证据显示APC用于上颌窦底提升的积极作用有限,但相关SR/MA的方法学质量和结局指标的可靠程度不一致,仍需开展高质量临床研究进一步验证。

关键词: 自体血小板, 上颌窦底提升, 临床研究, 系统再评价, AMSTAR 2, GRADE

Abstract: Objective To evaluate the quality of methodology and evidence of the systematic reviews and meta-analyses (SR/MA) of autologous platelet concentrates (APC) for maxillary sinus floor elevation (MSFE). Methods PubMed, Embase, Cochrane Library, Scopus, CNKI, SinoMed, and WanFang databases were electronically searched to enroll SR/MA of APC for MSFE from inception to August 31, 2022. Two reviewers independently screened literature, extracted data, and employed the AMSTAR 2 and the GRADE for evaluating the quality of methodology of the included studies and the certainty of the evidence for outcomes respectively. Results A total of 13 SR/MA were included and the major conclusions were that APC presents limited influence on MSFE and might promote the healing of sinus tissue. The 9 items of AMSTAR 2 were reported well, and two items were not reported in any of the included SRs, and the quality was relatively convinced. The evidence grading of GRADE revealed that, in the total of 46 outcomes, 9 were graded as high-level, 25 as medium-level, 11 as low-level, and 1 as extremely low-level. Conclusion Most of the current evidence shows the advantages of APC in MSFE are not obvious, but the reliability of SR/Ma is inconsistent. High-quality clinical trials are still needed to verify the efficacy of APC for MSFE

Key words: Autologous platelet, Maxillary sinus floor elevation, Clinical trials, Overview of systematic reviews, AMSTAR 2, GRADE

龚佳明,赵瑞敏,张启航,等. 自体血小板浓缩物用于上颌窦底提升的系统评价再评价[J]. 中国口腔种植学杂志, 2023, 28(2): 102-108. DOI: 10.12337/zgkqzzxzz.2023.04.006

Gong Jiaming, Zhao Ruimin, Zhang Qihang, Yu Zhanhai, Su Linhan. The autologous platelet concentrates for maxillary sinus floor elevation: an overview of systematic reviews[J].Chinese Journal of Oral Implantology, 2023, 28(2): 102-108.DOI: 10.12337/zgkqzzxzz.2023.04.006.

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自体血小板浓缩物用于上颌窦底提升的系统评价再评价

The autologous platelet concentrates for maxillary sinus floor elevation: an overview of systematic reviews

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