富血小板纤维蛋白促进骨再生效果的研究

doi:10.12337/zgkqzzxzz.2025.04.005

中国口腔种植学杂志 ›› 2025, Vol. 30 ›› Issue (2): 118-126.DOI: 10.12337/zgkqzzxzz.2025.04.005

• “自体血衍生物与牙种植”重点栏目 • 上一篇下一篇

富血小板纤维蛋白促进骨再生效果的研究

黄李蓉¹, 冯泽儒¹, 吴红崑¹, 莫安春²

¹口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院老年口腔科,成都 610041;
²口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院种植科,成都 610041

收稿日期:2025-01-10 出版日期:2025-04-30 发布日期:2025-04-21
通讯作者: 莫安春,Email：moanchun@163.com,电话：028-85503571
作者简介:黄李蓉博士研究生在读,研究方向：上颌窦底提升、美学区种植修复、骨缺损修复与种植治疗、骨再生及其相关研究。
莫安春教授、主任医师、博士研究生导师,研究方向：无牙颌种植修复、复杂骨增量、美学区种植修复、上颌窦底提升、骨再生及相关研究
基金资助:
国家重点研发计划重点项目（2023YFC2413603）; 四川省科技厅重点研发项目（2024YFFK0294）

Effect of platelet-rich fibrin on bone regeneration

Huang Lirong¹, Feng Zeru¹, Wu Hongkun¹, Mo Anchun²

¹State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
²State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Implant Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2025-01-10 Online:2025-04-30 Published:2025-04-21
Contact: Mo Anchun, Email: moanchun@163.com, Tel: 0086-28-85503571
Supported by:
National Key R & D Plan (2023YFC2413603); Key R & D Projects of the Department of Science and Technology of Sichuan Province (2024YFFK0294)

摘要/Abstract

摘要： 富血小板纤维蛋白（platelet-rich fibrin,PRF）作为第二代自体血小板浓缩物,凭借其良好的生物相容性和促进骨再生的能力,在口腔种植、颌面外科等领域得到广泛应用。PRF通过三维纤维蛋白网状结构持续释放生长因子促进成骨细胞活化、血管生成及骨组织重塑。在上颌窦底提升、骨增量、拔牙位点保存及即刻种植等手术中,PRF表现出优异的成骨效果和组织愈合能力,提高了种植体的稳定性和留存率。此外,在药物相关性颌骨坏死患者的治疗中PRF可有效抑制感染、减轻炎症反应,并促进组织愈合。然而,其临床效果易受个体生理差异、制备方法及降解速度等因素影响,部分研究中PRF的长期成骨效果表现不一,尤其在大范围骨缺损修复中,单独使用PRF难以满足需求。研究表明,通过优化离心参数、采血管材质及纤维结构可增强PRF的生物活性,而将PRF与骨增量材料、抗菌药物及生物支架结合,可进一步提升其在复杂病例中的应用潜力。此外,PRF联合纳米材料及水凝胶支架在血管生成和组织修复方面表现出一定优势,但目前尚缺乏长期随访数据。综上,PRF在骨再生领域具有广阔应用前景,但仍需进一步完善标准化制备流程和多学科联合应用策略,以提高其临床应用的稳定性和有效性。

关键词: 富血小板纤维蛋白, 上颌窦底提升, 牙槽嵴保存, 即刻种植, 药物相关性颌骨坏死

Abstract: Platelet-rich fibrin (PRF), a second-generation autologous platelet concentrate, has been widely used in oral implantology and maxillofacial surgery due to its excellent biocompatibility and bone regeneration capacity. PRF facilitates osteoblast activation, angiogenesis, and bone remodeling by sustained release of growth factors through its three-dimensional fibrin network. It has shown significant potential in sinus floor elevation, bone augmentation, extraction site preservation, and immediate implant placement, improving implant stability and survival rates. Additionally, PRF has shown efficacy in the treatment of medication-related osteonecrosis of the jaw (MRONJ) by reducing infection, alleviating inflammation, and promoting tissue healing. However, PRF's clinical outcomes are influenced by individual physiological differences, preparation methods, and degradation rates. PRF's long-term osteogenic effects, especially in severe bone defects, remain inconsistent. Optimizing centrifugation parameters, blood collection tube materials, and fiber structure, as well as combining PRF with bone grafts, antimicrobial drugs, and biomimetic scaffolds, can enhance its performance. Additionally, PRF combined with nanomaterials and hydrogel scaffolds shows potential advantages in angiogenesis and tissue regeneration, though long-term follow-up data remain limited. In conclusion, PRF holds significant promise in bone regeneration. However, further studies are required to establish standardized preparation protocols and multidisciplinary strategies to improve its clinical stability and efficacy.

Key words: Platelet-rich fibrin (PRF), Sinus floor elevation, Alveolar ridge preservation, Immediate implant placement, Medication-related osteonecrosis of the jaw (MRONJ)

黄李蓉,冯泽儒,吴红崑,等. 富血小板纤维蛋白促进骨再生效果的研究[J]. 中国口腔种植学杂志, 2025, 30(2): 118-126. DOI: 10.12337/zgkqzzxzz.2025.04.005

Huang Lirong, Feng Zeru, Wu Hongkun, Mo Anchun. Effect of platelet-rich fibrin on bone regeneration[J].Chinese Journal of Oral Implantology, 2025, 30(2): 118-126.DOI: 10.12337/zgkqzzxzz.2025.04.005.

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富血小板纤维蛋白促进骨再生效果的研究

Effect of platelet-rich fibrin on bone regeneration

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