骨膜细胞促进骨缺损修复的研究进展

doi:10.12337/zgkqzzxzz.2021.08.008

中国口腔种植学杂志 ›› 2021, Vol. 26 ›› Issue (4): 248-252.DOI: 10.12337/zgkqzzxzz.2021.08.008

骨膜细胞促进骨缺损修复的研究进展

朱婧娴, 施斌, 纪伟

口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室武汉大学口腔医学院武汉大学口腔医院口腔种植科,湖北 430079

收稿日期:2021-06-17 出版日期:2021-08-10 发布日期:2021-09-08
通讯作者: 施斌,Email: shibin_dentist@whu.edu.cn,电话:027-87686222;纪伟,Email: wei.ji@whu.edu.cn,电话:027-87686222
作者简介:朱婧娴博士生,主要研究方向：颌骨缺损与修复,种植体骨整合相关研究;施斌主任医师、教授、博士生导师;主要研究方向：种植义齿生物力学、种植体周围炎、骨缺损修复及种植体骨整合相关研究;纪伟副教授、硕士生导师。主要研究方向：骨组织工程、颌骨缺损与修复,种植体骨整合相关研究
基金资助:
湖北省自然科学基金(2020CFB618)

Research updates of periosteal cells in bone defect repair

Zhu Jingxian, Shi Bin, Ji Wei

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Department of Oral Implantology, School and Hospital of Stomatology, Wuhan University, Wuhan 430079,China

Received:2021-06-17 Online:2021-08-10 Published:2021-09-08
Contact: Shi Bin,Email:shibin_dentist@whu.edu.cn,Tel:0086-27-87686222, Ji Wei, Email: wei.ji@whu.edu.cn, Tel:0086-27-87686222
Supported by:
This Research is Funded by Natural Science Foundation of Hubei Province (No. 2020CFB618).

摘要/Abstract

摘要： 创伤、肿瘤等疾病导致的骨缺损在临床上十分常见,如何有效促进骨缺损修复仍是一大挑战。目前,越来越多的临床证据显示骨膜在促进骨缺损修复中起到了重要作用;一系列研究表明,缺损发生后,骨膜中的细胞可以动员迁移到骨缺损处,直接参与缺损修复。本文将对骨膜的发育来源、骨膜细胞在缺损修复中的生物学作用以及骨膜细胞群体的异质性加以综述,并对其临床应用前景以及未来研究方向加以展望。

关键词: 骨膜, 骨膜细胞, 骨缺损修复, 骨再生

Abstract: Reconstruction of bone defects caused by trauma, tumor resection, and congenital disease remains a great challenge. Currently, the periosteum, a thin fibrous layer that covers the surface of the bone, has drawn increasing attention owing to its important role in bone repair. Upon injury, periosteal cells migrate into the bone defect and differentiate into osteocytes or chondrocytes to repair the defect. In this review, we briefly described the developmental origin of the periosteum and the reparative function of periosteal cells. Furthermore, we introduced the heterogeneity of periosteal cells involved in bone repair as well as the underlying mechanism. In the end, we highlighted future research directions of periosteal cells that might be beneficial for the reconstruction of craniofacial bone defects.

Key words: Periosteum, Periosteal cells, Bone repair, Bone regeneration

朱婧娴,等施斌,等纪伟. 骨膜细胞促进骨缺损修复的研究进展[J]. 中国口腔种植学杂志, 2021, 26(4): 248-252. DOI: 10.12337/zgkqzzxzz.2021.08.008

Zhu Jingxian, Shi Bin, Ji Wei. Research updates of periosteal cells in bone defect repair[J].Chinese Journal of Oral Implantology, 2021, 26(4): 248-252.DOI: 10.12337/zgkqzzxzz.2021.08.008.

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骨膜细胞促进骨缺损修复的研究进展

Research updates of periosteal cells in bone defect repair

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