Research progress on the role and mechanism of the Wnt/Ca2+/CaMKⅡsignaling pathway in osteogenic regulation and diabetic bone metabolism disorders

doi:10.12337/zgkqzzxzz.2025.06.016

Abstract

Abstract: Diabetes mellitus (DM), a prevalent chronic metabolic disorder, is closely associated with disrupted bone metabolic homeostasis, which can impair osteoblast function through various molecular pathways, ultimately leading to abnormal bone metabolism. Additionally, diabetic oxidative stress can severely impair the process of new bone formation, leading to compromised osseointegration of the implant and even implant failure. Among these pathways, the Wnt/Ca²⁺/CaMKⅡ signaling axis plays a pivotal role in regulating osteoblast differentiation, bone matrix synthesis, and bone remodeling, all of which are essential processes in bone formation. This review systematically examines the impact of the Wnt/Ca²⁺/CaMKⅡ pathway on bone metabolic homeostasis in diabetic conditions, with a focus on the molecular mechanisms underlying diabetic bone metabolism disorders. Furthermore, the review discusses the potential of the Wnt/Ca²⁺/CaMKⅡpathway as a promising therapeutic target for managing diabetes-related bone lesions, providing novel insights into the intervention strategies for metabolic bone diseases and impaired osseointegration of dental implants in diabetic patients.

Key words: Wnt/Ca²⁺/CaMKⅡ pathway, Osteogenesis, Diabetes mellitus, Bone metabolism

Ding Jiaqi, Zhou Wenjuan. Research progress on the role and mechanism of the Wnt/Ca²⁺/CaMKⅡsignaling pathway in osteogenic regulation and diabetic bone metabolism disorders[J]. Chinese Journal of Oral Implantology, 2025, 30(3): 305-311.

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Research progress on the role and mechanism of the Wnt/Ca²⁺/CaMKⅡsignaling pathway in osteogenic regulation and diabetic bone metabolism disorders

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