Effect of topical minocycline combined with conventional antibiotics on modified plaque index, sICAM-1, and IL-1β in patients with post-implantation infection after dental implant surgery

doi:10.12337/zgkqzzxzz.2025.08.006

Abstract

Abstract: Objective To explore the effect of topical minocycline combined with conventional antibiotics on modified plaque index and soluble intercellular adhesion molecule-1 (sICMA-1) and interleukin-1β (1L-1β) after localized periodontitis. Methods A prospective study was conducted on 60 patients with localized periodontal disease who underwent dental implant surgery from May 2022 to September 2024. These patients were randomly divided into a control group and an observation group using a random number table method. The control group received routine antibiotics and conventional treatment for localized periodontal disease and dental implant surgery, while the observation group received minocycline hydrochloride ointment in addition to these treatments. The study compared the treatment outcomes, clinical indicators of periodontal soft tissue before and after intervention, and the levels of sICAM-1, IL-1β, matrix metalloproteinase-8 (MMP-8), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px). Results The total clinical effective rate in the observation group was 93.33%, which was higher than 70.00% in the control group (P<0.05). After intervention, the peri-implant pocket depth, plaque index, peri-implant mucosa index, and clinical attachment loss in both groups decreased (P<0.05), and those in the observation group were lower (P< 0.001). At 3 days, 7 days, and 1 month after intervention, the levels of sICAM-1, IL-1β, and MMP-8 in the peri-implant sulcular fluid of the observation group were lower than those of the control group (P<0.05), while the levels of SOD and GSH-Px in the peri-implant sulcular fluid were higher than those of the control group (P<0.05). Conclusion Minocycline hydrochloride ointment can reduce the oxidative stress response after dental implant surgery in localized periodontitis and improve the inflammatory state of peri-implantation.

Key words: Minocycline hydrochloride ointment, Localized periodontitis, Dental implant, Soluble intercellular adhesion molecule-1, Matrix metalloproteinase-8

Tang Mingchao, Zeng Qingxiang, Zhang Xiaoyan. Effect of topical minocycline combined with conventional antibiotics on modified plaque index, sICAM-1, and IL-1β in patients with post-implantation infection after dental implant surgery[J]. Chinese Journal of Oral Implantology, 2025, 30(4): 363-369.

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