Expression and clinical significance of matrix metalloproteinase-7 and -8 in the peri-implant mucosal sulcus fluid of patients with peri-implantitis

doi:10.12337/zgkqzzxzz.2025.02.011

Abstract

Abstract: Objective To analyze the levels of matrix metalloproteinase-7 (MMP-7) and MMP-8 in peri-implant mucosal sulcus fluid and their correlation with periodontal clinical indexes, as well as to evaluate their prognostic significance in patients with peri-implantitis (PI). Methods 72 patients with PI in our hospital were selected as the PI group, and another 50 peri-implant healthy individuals were selected as the control group. The levels of MMP-7 and MMP-8 in the peri-implant mucosal sulcus fluid were detected and compared between the two groups. Their correlation with periodontal clinical indexes in PI patients was analyzed. Then, PI patients were divided into a good prognosis group (n=49) and a poor prognosis groups (n=23) according to the acute physiology and chronic health evaluationⅡ (APACHEⅡ) score. Peri-implant mucosal sulcus fluid MMP-7 and MMP-8 levels were compared between the two subgroups, and the receiver operating characteristic (ROC) curve was used to analyze their predictive efficacy of these markers for poor prognosis in PI patients. Results The modified plaque index (mPLI), modified sulcus bleeding index (mSBI), probing depth (PD), and levels of MMP-7 and MMP-8 in the peri-implant mucosal sulcus fluid in the PI group were significantly higher than the control group (all P<0.05). Correlation analysis showed that peri-implant mucosal sulcus fluid MMP-7 and MMP-8 levels were positively correlated with mPLI, mSBI, and PD (r>0, P<0.05). The peri-implant mucosal sulcus fluid MMP-7 and MMP-8 levels in the poor prognosis group were higher than those in the good prognosis group (all P<0.05). ROC curve analysis showed that the area under the curve (AUC) for the peri-implant mucosal sulcus fluid MMP-7 and MMP-8 levels in predicting poor prognosis in PI patients was 0.712 and 0.786, respectively. The AUC for the combination of MMP-7 and MMP-8 in predicting poor prognosis was 0.823, which was significantly higher than that for MMP-7 alone (Z=2.067, P=0.039). Conclusion MMP-7 and MMP-8 levels in the peri-implant mucosal sulcus fluid are closely related to periodontal clinical indexes in PI patients and have significant predictive value for poor prognosis.

Key words: Peri-implantitis, Matrix metalloproteinase-7, Matrix metalloproteinase-8, Prognosis

Wang Fenying, Li Jing, Xu Xue. Expression and clinical significance of matrix metalloproteinase-7 and -8 in the peri-implant mucosal sulcus fluid of patients with peri-implantitis[J]. Chinese Journal of Oral Implantology, 2025, 30(1): 62-67.

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