Abstract: Peri-implantitis is the main cause of implant failure. However, the pathogenesis of peri-implantitis is still unclear. Effective treatments are also deficient. Animal models are important tools to explore pathogenesis and effective treatment methods. SD (Sprague-Dawley) rats are cheap and have a low cost of feeding. Biological reagents compatible with SD rats are also abundant. This article summarized three important aspects including design of the implant, time and site of implants, and methods of causing peri-implantitis to give property advice to researchers. In summary, It is close to the clinic to choose the design of the implant and healing abutment, implanting site of first molar region of maxillary, and implanting time of 3 weeks or 1 month after tooth extraction. Methods of causing peri-implantitis include inoculation of pathogenic bacteria, ligation of silk thread, and injection of lipopolysaccharide, which have their respective pros and cons. Researchers could choose different methods according to different purposes. At present, the hole preparation size and reaming drill speed for implant placement are not described clearly, which needs further research.

Key words: Peri-implantitis, Disease models, Rats