Abstract: Objective： To observe the clinical effect of using Er: YAG laser in combination with minocycline hy- drochloride ointment to treat peri-implantitis. Methods： A total of 52 single implants from 52 patients were randomized into study group(Er: YAG laser and minocycline hydrochloride ointment treatment group) and control group(manual scraping treatment group). The efficacy endpoints of plaque, bleeding and probing depth are measured respectively in pre-treatment, week 1, month 1 and month 3 after treat- ment and then analyzed statistically. Results： There is no significant difference of periodontal clinical in- dicators before treatment between the study group and the control group(P>0.05), and all the clinical effi- cacy endpoints after treatment in two groups improved (P<0.05), at the same time the effect of study group is better significantly(P<0.05). Conclusion： The Er: YAG laser in combination with minocycline hydrochloride ointment have clinical effect significantly on peri-implantitis.

Key words: Er: YAG laser, minocycline hydrochloride, peri-implantitis, effect