金属有机框架材料在口腔医学领域的研究进展

doi:10.12337/zgkqzzxzz.2024.12.025

摘要/Abstract

摘要： 金属有机框架（metal-organic frameworks,MOFs）是一类由金属节点与有机配体通过自组装形成的纳米多孔材料,具有高度有序的孔隙率和孔径、高比表面积和多样的结构。随着MOFs在生物医学领域的发展和应用,越来越多的研究者将MOFs引入口腔医学领域进行研究,并根据口腔环境和疾病的特点,改造或开发新的MOFs用于口腔领域疾病的治疗。口腔领域常用的MOFs主要是沸石型咪唑酸框架-8（zeolitic imidazolate framework-8,ZIF-8）和沸石型咪唑酸框架-67（zeolitic imidazolate framework-67,ZIF-67）2种材料。MOFs的结构及功能适用于口腔疾病的治疗,目前已被用于牙周病、口腔颌面部肿瘤、牙体牙髓病和口腔种植领域的研究并取得一定成果,但仍需临床试验的进一步验证。

关键词: 金属有机框架, 牙周病, 口腔颌面部肿瘤, 牙体牙髓病, 口腔种植

Abstract: Metal-organic frameworks (MOFs) are nanoporous materials synthesized through the self-assembly of metal nodes and organic ligands. They are characterized by their highly ordered porosity, tunable pore size, large specific surface area, and diverse structures. With the advancements and applications of MOFs in the biomedical field, an increasing number of researchers have introduced MOFs into dental medicine for research. New MOFs have been tailored or developed based on the characteristics of the oral environment and diseases for use in oral disease treatment. The most commonly used MOFs in dentistry primarily include zeolitic imidazolate framework-8 (ZIF-8) and zeolitic imidazolate framework-67 (ZIF-67). The structure and function of MOFs are suitable for treating oral diseases, and they have shown promising results in researches related to periodontal disease, oral and maxillofacial tumors, dental pulp disease, and dental implants. However, their effectiveness still requires further validation through clinical trials.

Key words: Metal-organic frameworks, Periodontal disease, Oral and maxillofacial tumors, Dental pulp disease, Dental implant

李健,梁晔,赵保东. 金属有机框架材料在口腔医学领域的研究进展[J]. 中国口腔种植学杂志, 2025, 29(6): 602-609. DOI: 10.12337/zgkqzzxzz.2024.12.025

Li Jian, Liang Ye, Zhao Baodong. Research progress on metal-organic frameworks in dental medicine[J].Chinese Journal of Oral Implantology, 2025, 29(6): 602-609.DOI: 10.12337/zgkqzzxzz.2024.12.025.

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