上颌窦底提升中骨增量材料的专家共识：生物活性制剂、细胞疗法与不植入骨增量材料的上颌窦底提升

doi:10.12337/zgkqzzxzz.2022.12.001

中国口腔种植学杂志 ›› 2022, Vol. 27 ›› Issue (6): 329-333.DOI: 10.12337/zgkqzzxzz.2022.12.001

• 指南与共识 • 下一篇

上颌窦底提升中骨增量材料的专家共识：生物活性制剂、细胞疗法与不植入骨增量材料的上颌窦底提升

中华口腔医学会口腔种植专业委员会
执笔专家：王宁涛（上海交通大学医学院附属第九人民医院）;王凤（上海交通大学医学院附属第九人民医院）;吴轶群（上海交通大学医学院附属第九人民医院）
专家组名单：吴轶群（上海交通大学医学院附属第九人民医院）;王凤（上海交通大学医学院附属第九人民医院）;陈卓凡（中山大学附属口腔医院）;兰晶（山东大学口腔医院）;王丽萍（广州医科大学附属口腔医院）;邹德荣（上海交通大学医学院附属第六人民医院）;周延民（吉林大学口腔医院）;宿玉成（中国医学科学院北京协和医院）
征求意见专家组名单（按姓氏汉语拼音排序）：陈泽涛, 陈卓凡, 黄伟, 兰晶, 李超伦, 宿玉成, 王凤, 王丽萍, 王跃平, 吴轶群, 张志勇, 周延民, 邹德荣

收稿日期:2022-08-11 出版日期:2022-12-30 发布日期:2023-01-03
通讯作者: 吴轶群,上海交通大学医学院附属第九人民医院口腔第二门诊部 201999,Email：yiqunwu@hotmail.com,电话：021-56152705;宿玉成,中国医学科学院北京协和医院口腔种植中心 100032,Email：yuchengsu@163.com,电话：010-66212299

Expert consensus on bone grafting materials for sinus floor elevation: bioactive agents, cell therapies and graft-free sinus floor elevation

Chinese Society of Oral Implantology
Writing authors: Wang Ningtao (Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine); Wang Feng (Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine); Wu Yiqun (Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine)
Authors: Wu Yiqun (Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine); Wang Feng (Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine); Chen Zhuofan (Hospital of Stomatology, Sun Yat-sen University); Lan Jing (Stomatological Hospital, Shandong University); Wang Liping (Affiliated Stomatology Hospital of Guangzhou Medical University); Zou Derong (Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine); Zhou Yanmin (Hospital of Stomatology, Jilin University); Su Yucheng (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences)
List of expert groups for comments (ranked by Chinese phonetic alphabet of surnames): Chen Zetao, Chen Zhuofan, Huang Wei, Lan Jing, Li Chaolun, Su Yucheng, Wang Feng, Wang Liping, Wang Yueping, Wu Yiqun, Zhang Zhiyong, Zhou Yanmin, Zou Derong

Received:2022-08-11 Online:2022-12-30 Published:2023-01-03
Contact: Wu Yiqun, Second Dental Center, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China, Email: yiqunwu@hotmail.com, Tel:0086-21-56152705; Su Yucheng, Dental Implant Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100032, China, Email: yuchengsu@163.com, Tel:0086-10-66212299

摘要/Abstract

摘要： 上颌窦底提升是解决上颌后牙区垂直向骨量不足的可靠方法。目前应用于上颌窦底骨增量的材料较多,关于材料的选择尚无统一共识。本文基于现有临床文献证据,针对生物活性制剂、细胞疗法以及不植入骨增量材料的上颌窦底提升进行总结及阐述,以期为临床上颌窦底提升中骨增量材料的选择提供参考。

关键词: 上颌窦底提升, 骨增量材料, 骨形态发生蛋白, 自体血小板浓缩制品, 干细胞, 不植入骨增量材料的上颌窦底提升, 专家共识

Abstract: Sinus floor elevation is a reliable approach to solve the problem of vertical bone deficiency in the posterior maxillary area. At present, there are many bone grafting materials available for sinus floor elevation, but no consensus on their selection is achieved. This consensus focuses on bioactive agents, cell therapies and graft-free sinus floor elevation, and summarizes the results on their clinical application, hoping to provide a reference for the selection during clinical practice.

Key words: Sinus floor elevation, Bone grafting materials, Bone morphogenetic protein, Autologous platelet concentrates (APCs), Stem cell, Graft-free sinus floor elevation, Expert consensus

. 上颌窦底提升中骨增量材料的专家共识：生物活性制剂、细胞疗法与不植入骨增量材料的上颌窦底提升[J]. 中国口腔种植学杂志, 2022, 27(6): 329-333. DOI: 10.12337/zgkqzzxzz.2022.12.001

Chinese Society of Oral Implantology. Expert consensus on bone grafting materials for sinus floor elevation: bioactive agents, cell therapies and graft-free sinus floor elevation[J].Chinese Journal of Oral Implantology, 2022, 27(6): 329-333.DOI: 10.12337/zgkqzzxzz.2022.12.001.

参考文献

[1] 宿玉成 .口腔种植学词典 [M].北京:人民卫生出版社,2020.
[2] 陆跃智, 张文杰, 蒋欣泉. Bmp-2与口腔颌面部骨再生[J].口腔生物医学,2020,11(4):207-213. DOI: 10.3969/j.issn.1674-8603.2020.04.001.
[3] Lin GH, Lim G, Chan HL, et al.Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and meta-analysis[J]. Clin Oral Implants Res, 2016,27(11):1349-1359. DOI: 10.1111/clr.12737.
[4] Kim HJ, Chung JH, Shin SY, et al.Efficacy of rhbmp-2/hydroxyapatite on sinus floor augmentation: a multicenter, randomized controlled clinical trial[J]. J Dent Res, 2015,94(9 Suppl):S158-S165. DOI: 10.1177/0022034515594573.
[5] Torrecillas-Martinez L, Monje A, Pikos MA, et al.Effect of rhbmp-2 upon maxillary sinus augmentation: a comprehensive review[J]. Implant Dent, 2013,22(3):232-237. DOI: 10.1097/ID.0b013e31829262a8.
[6] Kelly MP, Vaughn OL, Anderson PA.Systematic review and meta-analysis of recombinant human bone morphogenetic protein-2 in localized alveolar ridge and maxillary sinus augmentation[J]. J Oral Maxillofac Surg, 2016,74(5):928-939. DOI: 10.1016/j.joms.2015.11.027.
[7] Li F, Yu F, Liao X, et al.Efficacy of recombinant human BMP2 and PDGF-BB in orofacial bone regeneration: a systematic review and meta-analysis[J]. Sci Rep, 2019,9(1):8073. DOI: 10.1038/s41598-019-44368-z.
[8] Kim MS, Lee JS, Shin HK, et al.Prospective randomized, controlled trial of sinus grafting using escherichia-coli-produced rhBMP-2 with a biphasic calcium phosphate carrier compared to deproteinized bovine bone[J]. Clin Oral Implants Res, 2015,26(12):1361-1368. DOI: 10.1111/clr.12471.
[9] Woo EJ.Adverse events reported after the use of recombinant human bone morphogenetic protein 2[J]. J Oral Maxillofac Surg, 2012,70(4):765-767. DOI: 10.1016/j.joms.2011.09.008.
[10] Aoki N, Maeda M, Kurata M, et al.Sinus floor elevation with platelet-rich fibrin alone: a clinical retrospective study of 1-7 years[J]. J Clin Exp Dent, 2018,10(10):e984-e991. DOI: 10.4317/jced.55113.
[11] Molemans B, Cortellini S, Jacobs R, et al.Simultaneous sinus floor elevation and implant placement using leukocyte- and platelet-rich fibrin as a sole graft material[J]. Int J Oral Maxillofac Implants, 2019,34(5):1195-1201. DOI: 10.11607/jomi.7371.
[12] Ortega-Mejia H, Estrugo-Devesa A, Saka-Herrán C, et al.Platelet-rich plasma in maxillary sinus augmentation: systematic review[J]. Materials (Basel), 2020,13(3):622. DOI: 10.3390/ma13030622.
[13] Bassi AP, Pioto R, Faverani LP, et al.Maxillary sinus lift without grafting, and simultaneous implant placement: a prospective clinical study with a 51-month follow-up[J]. Int J Oral Maxillofac Surg, 2015,44(7):902-907. DOI: 10.1016/j.ijom.2015.03.016.
[14] Lemos CA, Mello CC, dos Santos DM, et al. Effects of platelet-rich plasma in association with bone grafts in maxillary sinus augmentation: a systematic review and meta-analysis[J]. Int J Oral Maxillofac Surg, 2016,45(4):517-525. DOI: 10.1016/j.ijom.2015.07.012.
[15] Nizam N, Eren G, Akcalı A, et al.Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: a split-mouth histological and histomorphometric study[J]. Clin Oral Implants Res, 2018,29(1):67-75. DOI: 10.1111/clr.13044.
[16] Miron RJ, Zucchelli G, Pikos MA, et al.Use of platelet-rich fibrin in regenerative dentistry: a systematic review[J]. Clin Oral Investig, 2017,21(6):1913-1927. DOI: 10.1007/s00784-017-2133-z.
[17] Shanbhag S, Suliman S, Pandis N, et al. Cell therapy for orofacial bone regeneration: a systematic review and meta-analysis[J]. J Clin Periodontol, 2019,46 Suppl 21:162-182. DOI: 10.1111/jcpe.13049.
[18] Pasquali PJ, Teixeira ML, de Oliveira TA, et al. Maxillary sinus augmentation combining bio-oss with the bone marrow aspirate concentrate: a histomorphometric study in humans[J]. Int J Biomater, 2015,2015:121286. DOI: 10.1155/2015/121286.
[19] Wildburger A, Payer M, Jakse N, et al.Impact of autogenous concentrated bone marrow aspirate on bone regeneration after sinus floor augmentation with a bovine bone substitute--a split-mouth pilot study[J]. Clin Oral Implants Res, 2014,25(10):1175-1181. DOI: 10.1111/clr.12228.
[20] 鄢明东, 夏海斌, 王敏. 上颌窦底内提升不植骨同期牙种植的临床研究进展[J].国际口腔医学杂志,2018,45(2): 238-244. DOI: 10.7518/gjkq.2018.02.021.
[21] Chiarello E, Cadossi M, Tedesco G, et al. Autograft, allograft and bone substitutes in reconstructive orthopedic surgery[J]. Aging Clin Exp Res, 2013,25 Suppl 1:S101-S103. DOI: 10.1007/s40520-013-0088-8.
[22] Duan DH, Fu JH, Qi W, et al.Graft-free maxillary sinus floor elevation: a systematic review and meta-analysis[J]. J Periodontol, 2017,88(6):550-564. DOI: 10.1902/jop.2017.160665.
[23] Ye M, Liu W, Cheng S, et al.Outcomes of implants placed after osteotome sinus floor elevation without bone grafts: a systematic review and meta-analysis of single-arm studies[J]. Int J Implant Dent, 2021,7(1):72. DOI: 10.1186/s40729-021-00358-3.

上颌窦底提升中骨增量材料的专家共识：生物活性制剂、细胞疗法与不植入骨增量材料的上颌窦底提升

Expert consensus on bone grafting materials for sinus floor elevation: bioactive agents, cell therapies and graft-free sinus floor elevation

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	周延民, 秦秋月. 上颌窦三维成骨模式促进上颌窦内成骨的临床意义[J]. 中国口腔种植学杂志, 2023, 28(2): 69-76.
[2]	余正荣, 郭水根, 杨晶晶, 毛卫华, 魏洪武. 上颌窦解剖因素对穿牙槽嵴上颌窦底提升骨增量材料改建影响的研究[J]. 中国口腔种植学杂志, 2023, 28(2): 82-89.
[3]	龚佳明, 赵瑞敏, 张启航, 余占海, 苏琳涵. 自体血小板浓缩物用于上颌窦底提升的系统评价再评价[J]. 中国口腔种植学杂志, 2023, 28(2): 102-108.
[4]	陈德平, 刘倩, 皮雪敏, 潘红, 任斌, 宿玉成. 穿牙槽嵴上颌窦底提升的临床程序[J]. 中国口腔种植学杂志, 2023, 28(2): 128-132.
[5]	中华口腔医学会口腔种植专业委员会. 上颌窦底提升骨增量材料的专家共识：骨代用品[J]. 中国口腔种植学杂志, 2023, 28(1): 3-8.
[6]	周延民, 朱悦萌. 上颌窦三维成骨模式构建[J]. 中国口腔种植学杂志, 2023, 28(1): 9-18.
[7]	邓磊, 黄海涛. 上颌窦底提升术后窦腔内成骨机制的研究进展[J]. 中国口腔种植学杂志, 2023, 28(1): 53-57.
[8]	皮雪敏, 刘倩, 陈德平, 任斌, 潘红, 宿玉成. 上颌窦底提升方案的决策原则（三）[J]. 中国口腔种植学杂志, 2023, 28(1): 58-66.
[9]	皮雪敏, 陈德平, 刘倩, 任斌, 潘红, 宿玉成. 上颌窦底提升方案的决策原则（二）[J]. 中国口腔种植学杂志, 2022, 27(6): 387-392.
[10]	中华口腔医学会口腔种植专业委员会. 上颌窦底提升并发症的专家共识：种植体脱入上颌窦（第一版）[J]. 中国口腔种植学杂志, 2022, 27(5): 264-268.
[11]	中华口腔医学会口腔种植专业委员会. 上颌窦底提升中骨增量材料的专家共识：自体骨[J]. 中国口腔种植学杂志, 2022, 27(5): 269-273.
[12]	钱印杰, 姒蜜思. 亲水性大颗粒喷砂酸蚀表面种植体促进骨缺损区域骨结合的研究进展[J]. 中国口腔种植学杂志, 2022, 27(5): 317-321.
[13]	皮雪敏, 刘倩, 陈德平, 任斌, 潘红, 宿玉成. 上颌窦底提升方案的决策原则（一）[J]. 中国口腔种植学杂志, 2022, 27(5): 322-326.
[14]	中华口腔医学会口腔种植专业委员会. 上颌窦底提升并发症的专家共识：良性阵发性位置性眩晕（第一版）[J]. 中国口腔种植学杂志, 2022, 27(4): 204-207.
[15]	王婷婷, 王凤, 吴轶群. 3D打印数字化个性化钛网在牙槽嵴引导骨再生中的临床应用[J]. 中国口腔种植学杂志, 2022, 27(4): 208-216.