上颌窦三维成骨模式促进上颌窦内成骨的临床意义

doi:10.12337/zgkqzzxzz.2023.04.001

中国口腔种植学杂志 ›› 2023, Vol. 28 ›› Issue (2): 69-76.DOI: 10.12337/zgkqzzxzz.2023.04.001

• 专家笔谈 • 下一篇

上颌窦三维成骨模式促进上颌窦内成骨的临床意义

周延民, 秦秋月

吉林大学口腔医学院种植中心,长春 130021

收稿日期:2023-01-18 出版日期:2023-04-30 发布日期:2023-05-04
通讯作者: 周延民,Email: zhouym@jlu.edu.cn,电话：0431-88796025
作者简介:周延民,二级教授,一级主任医师,博士生导师。中国白求恩式好医生,白求恩名师,国务院政府特殊津贴获得者。现任吉林大学唐敖庆学者领军教授B岗、长白山学者、国际牙医学院院士（fellow）、世界牙科会议组织（FDI）委员会委员、国际口腔种植学会（ITI）中国分会fellow、泛太平洋口腔种植协会（PPIS）委员、International College of Prosthodontists（ICP）委员、国际口腔重建科学委员会（FOR）中国分会委员、瑞典卡罗林斯卡学院高级访问学者。中华口腔医学会副会长、中国医师协会口腔医师分会副会长、中国医院协会口腔医院分会副主任委员、中华口腔医学会口腔种植专业委员会副主任委员、中华口腔医学会第七届口腔修复学专业委员会副主任委员。吉林省口腔医学会会长,吉林省口腔种植专业委员会主任委员。专业擅长：骨增量、软组织增量,疑难条件种植,种植美学,全口种植,精准微创种植,即刻种植即刻修复,数字化种植,固定义齿,全口种植义齿的复杂病例设计及修复,咬合重建等。

Clinical implications of 3-dimensional osteogenesis model for maxillary sinus to promote osteogenesis in maxillary sinus

Zhou Yanmin, Qin Qiuyue

Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China

Received:2023-01-18 Online:2023-04-30 Published:2023-05-04
Contact: Zhou Yanmin, Email: zhouym@jlu.edu.cn, Tel: 0086-431-88796025

摘要/Abstract

摘要： “上颌窦三维成骨模式”（3-dimensional osteogenesis model for maxillary sinus,3D-OMMS）的提出阐明了上颌窦底提升的成骨机制,为临床中上颌后牙缺失患者进行上颌窦底提升的治疗提供了科学的理论依据。本文结合临床病例,从施耐德膜的成骨潜力、双骨皮质支持、骨增量材料的应用及种植体表面改性四个方面阐述了“3D-OMMS” 促进上颌窦内成骨的机制和临床意义。临床应用中包括单颗牙或多颗牙;即刻和延期种植;穿牙槽嵴上颌窦底提升以及侧壁开窗上颌窦底提升等术式,通过患者术前术后的计算机体层扫描（cone-beam computed tomography,CBCT）影像评估上颌窦区成骨效果。可见应用3D-OMMS,在上颌窦中形成成骨方向多元化的三维空间,缩短血管化成骨路径、加速成骨进程、提高新骨质量、增加种植成功率,因此在临床工作中可以被广泛应用。

关键词: 上颌窦底提升, 上颌窦三维成骨模式, 牙种植, 骨增量

Abstract: The "3-dimensional osteogenesis model for maxillary sinus" (3D-OMMS) elucidated the osteogenic mechanism of maxillary sinus floor elevation. It provides a scientific theoretical basis for the treatment of maxillary sinus floor elevation in patients with missing maxillary posterior teeth. This manuscript reports the clinical application of "3D-OMMS" in the implants including single tooth or multiple teeth, immediate and delayed implants, transalveolar sinus floor elevation and lateral window approach sinus floor elevation, respectively. Preoperative and postoperative cone-beam computed tomography（CBCT）images were used to evaluate the osteogenic effect of the maxillary sinus region. In conclusion, the application of 3D-OMMS can form a three-dimensional space with diversified osteogenic directions in the maxillary sinus, shorten the vascularization osteogenesis path, accelerate the osteogenic process, improve the quality of new bone, and increase the success rate of implantation, which can be widely used in clinical practice.

Key words: Sinus floor elevation, 3-dimensional osteogenesis model for maxillary sinus, Dental implant, Bone augmentation

周延民,等秦秋月. 上颌窦三维成骨模式促进上颌窦内成骨的临床意义[J]. 中国口腔种植学杂志, 2023, 28(2): 69-76. DOI: 10.12337/zgkqzzxzz.2023.04.001

Zhou Yanmin, Qin Qiuyue. Clinical implications of 3-dimensional osteogenesis model for maxillary sinus to promote osteogenesis in maxillary sinus[J].Chinese Journal of Oral Implantology, 2023, 28(2): 69-76.DOI: 10.12337/zgkqzzxzz.2023.04.001.

参考文献

[1] Srouji S, Ben-David D, Lotan R, et al.The innate osteogenic potential of the maxillary sinus (Schneiderian) membrane: an ectopic tissue transplant model simulating sinus lifting[J]. Int J Oral Maxillofac Surg, 2010,39(8):793-801. DOI: 10.1016/j.ijom.2010.03.009.
[2] Cricchio G, Palma VC, Faria PE, et al.Histological outcomes on the development of new space-making devices for maxillary sinus floor augmentation[J]. Clin Implant Dent Relat Res, 2011,13(3):224-230. DOI: 10.1111/j.1708-8208.2009.00208.x.
[3] Dragonas P, Katsaros T, Schiavo J, et al.Osteogenic capacity of the sinus membrane following maxillary sinus augmentation procedures: a systematic review[J]. International Journal of Oral Implantology, 2020, 13(3): 213-232.
[4] Wang J, Sun Y, Liu Y, et al.Effects of platelet-rich fibrin on osteogenic differentiation of Schneiderian membrane derived mesenchymal stem cells and bone formation in maxillary sinus[J]. Cell Commun Signal, 2022,20(1):88. DOI: 10.1186/s12964-022-00844-0.
[5] Liu Y, Wang J, Zhai P, et al.Stiffness regulates the morphology, adhesion, proliferation, and osteogenic differentiation of maxillary Schneiderian sinus membrane-derived stem cells[J]. Stem Cells Int, 2021,2021:8868004. DOI: 10.1155/2021/8868004.
[6] 于继泽. 富血小板纤维蛋白中生长因子对兔上颌窦黏膜衍生细胞上皮-间充质转化及多向分化的作用[C].2020年中华口腔医学会口腔生物医学专业委员会第十次全国口腔生物医学学术年会暨第六次全国口腔杰青优青论坛论文汇编. 2020:265-266. DOI: 10.26914/c.cnkihy.2020.046233.
[7] 徐静, 吕慧欣, 王一涵, 等. Nell-1蛋白通过Wnt/β-catenin通路调控人上颌窦黏膜来源间充质干细胞成骨分化[J].口腔医学研究,2023,39(3):227-235. DOI: 10.13701/j.cnki.kqyxyj.2023.03.009
[8] Weng Y, Wang H, Wu D, et al.A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL[J]. Cell Res, 2022,32(9):814-830. DOI: 10.1038/s41422-022-00687-x.
[9] Bresaola MD, Matsumoto MA, Zahoui A, et al.Influence of rapid- and slow-rate resorption collagen membrane in maxillary sinus augmentation[J]. Clin Oral Implants Res, 2017,28(3):320-326. DOI: 10.1111/clr.12801.
[10] Zhou Y, Gong C, Hossaini-Zadeh M, et al.3D full-field strain in bone-implant and bone-tooth constructs and their morphological influential factors[J]. J Mech Behav Biomed Mater, 2020,110:103858. DOI: 10.1016/j.jmbbm.2020.103858.
[11] Lofaj F, Kučera J, Németh D, et al.Finite element analysis of stress distributions in mono-and bi-cortical dental implants[J]. Mater Sci Eng C Mater Biol Appl, 2015,50:85-96. DOI: 10.1016/j.msec.2015.01.095.
[12] Yan X, Zhang X, Chi W, et al.Association between implant apex and sinus floor in posterior maxilla dental implantation: a three-dimensional finite element analysis[J]. Exp Ther Med, 2015,9(3):868-876. DOI: 10.3892/etm.2015.2205.
[13] Pjetursson BE, Rast C, Brägger U, et al.Maxillary sinus floor elevation using the (transalveolar) osteotome technique with or without grafting material. Part I: implant survival and patients' perception[J]. Clin Oral Implants Res, 2009,20(7):667-676. DOI: 10.1111/j.1600-0501.2009.01704.x.
[14] Yan X, Zhang X, Chi W, et al.Comparing the influence of crestal cortical bone and sinus floor cortical bone in posterior maxilla bi-cortical dental implantation: a three-dimensional finite element analysis[J].Acta Odontol Scand,2015,73(4):312-320.DOI: 10.3109 /00016357.2014.967718.
[15] Wang X, Zhang T, Yang E, et al.Biomechanical analysis of grafted and nongrafted maxillary sinus augmentation in the atrophic posterior maxilla with three-dimensional finite element method[J]. Scanning, 2020(6):1-8. DOI: 10.1155/2020/8419319.
[16] Starch-Jensen T, Deluiz D, Bruun NH, et al.Maxillary sinus floor augmentation with autogenous bone graft alone compared with alternate grafting materials: a systematic review and meta-analysis focusing on histomorphometric outcome[J]. J Oral Maxillofac Res, 2020,11(3):e2. DOI: 10.5037/jomr.2020.11302.
[17] Starch-Jensen T, Deluiz D, Vitenson J, et al.Maxillary sinus floor augmentation with autogenous bone graft compared with a composite grafting material or bone substitute alone: a systematic review and meta-analysis assessing volumetric stability of the grafting material[J]. J Oral Maxillofac Res, 2021,12(1):e1. DOI: 10.5037/jomr.2021.12101.
[18] Pitzurra L, Jansen I, de Vries TJ, et al. Effects of L-PRF and A-PRF+ on periodontal fibroblasts in in vitro wound healing experiments[J]. J Periodontal Res, 2020,55(2):287-295. DOI: 10.1111/jre.12714.
[19] Miron RJ, Moraschini V, Fujioka-Kobayashi M, et al.Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis[J]. Clin Oral Investig, 2021,25(5):2461-2478. DOI: 10.1007/s00784-021-03825-8.
[20] Mudalal M, Wang Z, Mustafa S, et al.Effect of leukocyte-platelet rich fibrin (L-PRF) on tissue regeneration and proliferation of human gingival fibroblast cells cultured using a modified method[J]. Tissue Eng Regen Med, 2021,18(5):895-904. DOI: 10.1007/s13770-021-00360-1.
[21] Liu Y, Sun X, Yu J, et al.Platelet-rich fibrin as a bone graft material in oral and maxillofacial bone regeneration: classification and summary for better application[J]. Biomed Res Int, 2019(9):1-16. DOI: 10.1155/2019/3295756.
[22] Li Q, Reed DA, Min L, et al.Lyophilized platelet-rich fibrin (PRF) promotes craniofacial bone regeneration through Runx2[J]. Int J Mol Sci, 2014,15(5):8509-8525. DOI: 10.3390/ijms15058509.
[23] 中华口腔医学会口腔种植专业委员会. 上颌窦底提升中骨增量材料的专家共识:生物活性制剂、细胞疗法与不植入骨增量材料的上颌窦底提升[J].中国口腔种植学杂志, 2022,27(6):329-333. DOI:10.12337/zgkqzzxzz. 2022. 12. 001.
[24] Ting M, Jefferies SR, Xia W, et al.Classification and effects of implant surface modification on the bone: human cell-based in vitro studies[J]. J Oral Implantol, 2017,43(1):58-83. DOI: 10.1563/aaid-joi-D-16-00079.
[25] Xie J, Rittel D, Shemtov-Yona K, et al.A stochastic micro to macro mechanical model for the evolution of bone-implant interface stiffness[J]. Acta Biomater, 2021,131:415-423. DOI: 10.1016/j.actbio.2021.06.019.
[26] Souza J, Sordi MB, Kanazawa M, et al.Nano-scale modification of titanium implant surfaces to enhance osseointegration[J]. Acta Biomater, 2019,94:112-131. DOI: 10.1016/j.actbio.2019.05.045.
[27] Favero V, Lang NP, Rossi F, et al.Peri-implant tissues morphometry at SLActive surfaces. An experimental study in the dog[J]. Clin Oral Implants Res, 2016,27(8):993-998. DOI: 10.1111/clr.12719.
[28] Chatzopoulos GS, Wolff LF.Survival rates and factors affecting the outcome following immediate and delayed implant placement: a retrospective study[J]. J Clin Med, 2022,11(15):4598. DOI: 10.3390/jcm11154598.
[29] 赵宁波, 杜良智, 常晓峰, 等. 两种上颌窦底提升术的短期临床效果研究[J].中国实用口腔科杂志,2022,15(5):569-573. DOI: 10.19538/j.kq.2022.05.011.
[30] Wang Y, Zhang Y, Miron RJ.Health, maintenance, and recovery of soft tissues around implants[J]. Clin Implant Dent Relat Res, 2016,18(3):618-634. DOI: 10.1111/cid.12343.

上颌窦三维成骨模式促进上颌窦内成骨的临床意义

Clinical implications of 3-dimensional osteogenesis model for maxillary sinus to promote osteogenesis in maxillary sinus

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