局部使用盐酸米诺环素联合常规抗生素对伴局限性牙周炎的种植术后感染患者菌斑指数及sICAM-1、IL-1β的影响

doi:10.12337/zgkqzzxzz.2025.08.006

摘要/Abstract

摘要： 目的探析局部使用盐酸米诺环素联合常规口服抗生素对有牙周病并行牙种植术后感染患者的菌斑指数及可溶性细胞间黏附分子-1（sICAM-1）和白细胞介素-1β（IL - 1β）等的变化。方法对2022年5月至2024年9月收治的60例局限性牙周炎种植牙术后感染患者进行前瞻性研究,以随机数字表法分为对照组与观察组,对照组给予常规口服抗生素及局限性牙周炎治疗及种植治疗,观察组在上述基础上再给予盐酸米诺环素软膏局部治疗。对比2组疗效、干预前后种植体周软组织临床指标及种植体周黏膜沟液检测指标,包括sICAM-1、IL-1β、基质金属蛋白酶-8（MMP-8）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）。结果观察组临床总有效率93.33%,高于对照组70.00%（P<0.05）;干预后2组种植体周探诊深度、菌斑指数、种植体周牙龈指数及临床附着丧失均降低（P<0.05）,且观察组更低（P<0.001）;干预3 d、7 d、1个月后,观察组种植体周黏膜沟液sICAM-1、IL-1β及MMP-8水平低于对照组（P<0.05）,种植体周黏膜沟液SOD、GSH-Px水平高于对照组（P<0.05）。结论盐酸米诺环素软膏可减轻局限性牙周炎患者种植牙后氧化应激反应,改善种植体周炎症状态。

关键词: 盐酸米诺环素软膏, 局限性牙周炎, 牙种植, 可溶性细胞间黏附分子-1, 基质金属蛋白酶-8

Abstract: Objective To explore the effect of topical minocycline combined with conventional antibiotics on modified plaque index and soluble intercellular adhesion molecule-1 (sICMA-1) and interleukin-1β (1L-1β) after localized periodontitis. Methods A prospective study was conducted on 60 patients with localized periodontal disease who underwent dental implant surgery from May 2022 to September 2024. These patients were randomly divided into a control group and an observation group using a random number table method. The control group received routine antibiotics and conventional treatment for localized periodontal disease and dental implant surgery, while the observation group received minocycline hydrochloride ointment in addition to these treatments. The study compared the treatment outcomes, clinical indicators of periodontal soft tissue before and after intervention, and the levels of sICAM-1, IL-1β, matrix metalloproteinase-8 (MMP-8), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px). Results The total clinical effective rate in the observation group was 93.33%, which was higher than 70.00% in the control group (P<0.05). After intervention, the peri-implant pocket depth, plaque index, peri-implant mucosa index, and clinical attachment loss in both groups decreased (P<0.05), and those in the observation group were lower (P< 0.001). At 3 days, 7 days, and 1 month after intervention, the levels of sICAM-1, IL-1β, and MMP-8 in the peri-implant sulcular fluid of the observation group were lower than those of the control group (P<0.05), while the levels of SOD and GSH-Px in the peri-implant sulcular fluid were higher than those of the control group (P<0.05). Conclusion Minocycline hydrochloride ointment can reduce the oxidative stress response after dental implant surgery in localized periodontitis and improve the inflammatory state of peri-implantation.

Key words: Minocycline hydrochloride ointment, Localized periodontitis, Dental implant, Soluble intercellular adhesion molecule-1, Matrix metalloproteinase-8

汤明超,曾庆祥,张小燕. 局部使用盐酸米诺环素联合常规抗生素对伴局限性牙周炎的种植术后感染患者菌斑指数及sICAM-1、IL-1β的影响[J]. 中国口腔种植学杂志, 2025, 30(4): 363-369. DOI: 10.12337/zgkqzzxzz.2025.08.006

Tang Mingchao, Zeng Qingxiang, Zhang Xiaoyan. Effect of topical minocycline combined with conventional antibiotics on modified plaque index, sICAM-1, and IL-1β in patients with post-implantation infection after dental implant surgery[J].Chinese Journal of Oral Implantology, 2025, 30(4): 363-369.DOI: 10.12337/zgkqzzxzz.2025.08.006.

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