Abstract: Platelet-rich fibrin (PRF), a second-generation autologous platelet concentrate, has been widely used in oral implantology and maxillofacial surgery due to its excellent biocompatibility and bone regeneration capacity. PRF facilitates osteoblast activation, angiogenesis, and bone remodeling by sustained release of growth factors through its three-dimensional fibrin network. It has shown significant potential in sinus floor elevation, bone augmentation, extraction site preservation, and immediate implant placement, improving implant stability and survival rates. Additionally, PRF has shown efficacy in the treatment of medication-related osteonecrosis of the jaw (MRONJ) by reducing infection, alleviating inflammation, and promoting tissue healing. However, PRF's clinical outcomes are influenced by individual physiological differences, preparation methods, and degradation rates. PRF's long-term osteogenic effects, especially in severe bone defects, remain inconsistent. Optimizing centrifugation parameters, blood collection tube materials, and fiber structure, as well as combining PRF with bone grafts, antimicrobial drugs, and biomimetic scaffolds, can enhance its performance. Additionally, PRF combined with nanomaterials and hydrogel scaffolds shows potential advantages in angiogenesis and tissue regeneration, though long-term follow-up data remain limited. In conclusion, PRF holds significant promise in bone regeneration. However, further studies are required to establish standardized preparation protocols and multidisciplinary strategies to improve its clinical stability and efficacy.

Key words: Platelet-rich fibrin (PRF), Sinus floor elevation, Alveolar ridge preservation, Immediate implant placement, Medication-related osteonecrosis of the jaw (MRONJ)