Research progress on metal-organic frameworks in dental medicine

doi:10.12337/zgkqzzxzz.2024.12.025

Abstract

Abstract: Metal-organic frameworks (MOFs) are nanoporous materials synthesized through the self-assembly of metal nodes and organic ligands. They are characterized by their highly ordered porosity, tunable pore size, large specific surface area, and diverse structures. With the advancements and applications of MOFs in the biomedical field, an increasing number of researchers have introduced MOFs into dental medicine for research. New MOFs have been tailored or developed based on the characteristics of the oral environment and diseases for use in oral disease treatment. The most commonly used MOFs in dentistry primarily include zeolitic imidazolate framework-8 (ZIF-8) and zeolitic imidazolate framework-67 (ZIF-67). The structure and function of MOFs are suitable for treating oral diseases, and they have shown promising results in researches related to periodontal disease, oral and maxillofacial tumors, dental pulp disease, and dental implants. However, their effectiveness still requires further validation through clinical trials.

Key words: Metal-organic frameworks, Periodontal disease, Oral and maxillofacial tumors, Dental pulp disease, Dental implant

Li Jian, Liang Ye, Zhao Baodong. Research progress on metal-organic frameworks in dental medicine[J]. Chinese Journal of Oral Implantology, 2025, 29(6): 602-609.

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