Inflammatory modulation and applications of biomaterials in oral bone regeneration

doi:10.12337/zgkqzzxzz.2023.10.002

Abstract

Abstract: Significant progress has been made in the field of oral bone regeneration, with growing recognition of the pivotal role played by inflammation regulation. Temporal and contextual regulation of inflammation is essential for achieving successful bone repair. In the context of oral bone regeneration, biomaterials are employed as scaffolds/bone grafts to promote bone tissue formation in defect areas. The intrinsic properties of biomaterials may impact the inflammatory process and its regulation. Additionally, biomaterials can serve as carriers for immuno-modulatory drugs, further influencing bone regeneration. A comprehensive understanding of how biomaterials modulate inflammatory responses holds the potential to accelerate the development of novel bone regeneration materials. This review provides an overview of the current status of research on biomaterials in the context of oral bone regeneration and inflammation response, summarizing the laboratory advancements. The aim is to provide clinicians and researchers with a theoretical foundation for the selection and development of regenerative materials.

Key words: Bone regeneration, Inflammation response, Biomaterials, Macrophages

Zhang Yufeng, Wang Yulan. Inflammatory modulation and applications of biomaterials in oral bone regeneration[J]. Chinese Journal of Oral Implantology, 2023, 28(5): 304-309.

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