Abstract: Objective： To study and analyze the changes of CD3、CD4+、CD8+、IL-2、IL-6 and TNF-α levels in patients with recurrent oral ulcer treated with dental implants. Methods： From February 2016 to Decem- ber 2018, 60 patients with previous dental implants and recurrent oral ulcer admitted to our hospital as ob- servation objects were recorded as the experimental group. In addition, 60 cases of previous dental im- plant personnel who underwent physical examination in our hospital in the same period were recorded as the control group. CD3+, CD4+, and CD8+ levels were detected by flow cytometry, and CD4+/CD8+ values were calculated. Meanwhile, serum levels of interleukin-2(IL-2), interleukin-6 (IL-6) and tumor necro- sis factor-α(TNF-α) were detected by enzyme-linked immunosorbent assay. Correlation analysis was al- so maken. Results： The CD4+ and CD8+ levels in the experimental group were(35.01±4.23)% and(33.22± 5.37) %, respectively higher than the control group(31.76±3.82)% and(22.17±3.98)%. The CD4+/CD8+ level(1.26±0.61) was lower than the control group (1.87±0.89) (all P<0.05). The serum IL-2, IL-6 and TNF-α levels in the experimental group were(39.77±3.58) pg/ml, (2.81±0.50) pg/ml, (15.59±3.79) pg/ml, compared with the control group(23.05±10.24) pg/ml, (0.72±0.15) pg/ml, (10.24±1.28) pg/ml was higher (all P<0.05). Pearson correlation analysis showed that CD4+ and CD8+ levels were positively correlated with serum IL-2, IL-6 and TNF-α levels, while CD4+/CD8+ levels were negatively correlated with serum IL-2, IL-6 and TNF-α levels(all P<0.05). Conclusion： CD4+ and CD8+ levels were significantly higher in patients with dental implants and recurrent oral ulcer, while CD4+/CD8+ levels were significantly lower, suggesting that immune dysfunction may be closely related to the occurrence and development of recur- rent oral ulcer. In clinical work, serum IL-2, IL-6 and TNF-α levels may be jointly detected to reflect the immune function of patients.

Key words: recurrent oral ulcer, previous dental implants, interleukines, tumor necrosis factor-α, immune function