Chinese Journal of Oral Implantology

The influence of vancomycin on osteogenic efficacy of BMP2-coprecipated biomimetic calcium phosphate granules

WANG Dongyun, LUO Yuan, PENG Juanhong

2019, 24(2): 51-54. DOI: 10.12337/zgkqzzxzz.2019.06.001

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Objective： To investigate the influence of vancomycin on osteogenic efficacy of BMP2-coprecipated biomimetic calcium phosphate granules. Methods： After being seeded on BioCaP-BMP2 granules, BM- SCs were treated with vancomycin at concentration of 0,1, 10, 30μg/ml. Cell proliferation was detected at 1, 4, 7 days by CCk8 assay. Total protein, alkaline phosphatase activity and osteocalcin expression were examined at 4 and 7 days. Results： Compared with control group, vancomycin at concentration of 1 and 10μg/ml did not show negative effects on the biological behavior of BMSCs. On the contrary, high concen- tration of vancomycin was found to inhibit the proliferation and osteogenic differentiation of BMSCs. Conclusion: Therapeutic concentration of vancomycin will not negatively influence the osteogenic efficacy of BioCaP-BMP2, which means BioCaP-BMP2 granules carrying vancomycin could be a promising material to treat infectious bone defects.

Analysis on the changes of CD3+、CD4+、CD8+、IL-2、IL-6 and TNF-α levels in patients with recurrent oral ulcer treated with dental implants

SHI Hairui, KONG Yihua, WNAG Xianhe, et al

2019, 24(2): 55-58. DOI: 10.12337/zgkqzzxzz.2019.06.002

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Objective： To study and analyze the changes of CD3、CD4+、CD8+、IL-2、IL-6 and TNF-α levels in patients with recurrent oral ulcer treated with dental implants. Methods： From February 2016 to Decem- ber 2018, 60 patients with previous dental implants and recurrent oral ulcer admitted to our hospital as ob- servation objects were recorded as the experimental group. In addition, 60 cases of previous dental im- plant personnel who underwent physical examination in our hospital in the same period were recorded as the control group. CD3+, CD4+, and CD8+ levels were detected by flow cytometry, and CD4+/CD8+ values were calculated. Meanwhile, serum levels of interleukin-2(IL-2), interleukin-6 (IL-6) and tumor necro- sis factor-α(TNF-α) were detected by enzyme-linked immunosorbent assay. Correlation analysis was al- so maken. Results： The CD4+ and CD8+ levels in the experimental group were(35.01±4.23)% and(33.22± 5.37) %, respectively higher than the control group(31.76±3.82)% and(22.17±3.98)%. The CD4+/CD8+ level(1.26±0.61) was lower than the control group (1.87±0.89) (all P<0.05). The serum IL-2, IL-6 and TNF-α levels in the experimental group were(39.77±3.58) pg/ml, (2.81±0.50) pg/ml, (15.59±3.79) pg/ml, compared with the control group(23.05±10.24) pg/ml, (0.72±0.15) pg/ml, (10.24±1.28) pg/ml was higher (all P<0.05). Pearson correlation analysis showed that CD4+ and CD8+ levels were positively correlated with serum IL-2, IL-6 and TNF-α levels, while CD4+/CD8+ levels were negatively correlated with serum IL-2, IL-6 and TNF-α levels(all P<0.05). Conclusion： CD4+ and CD8+ levels were significantly higher in patients with dental implants and recurrent oral ulcer, while CD4+/CD8+ levels were significantly lower, suggesting that immune dysfunction may be closely related to the occurrence and development of recur- rent oral ulcer. In clinical work, serum IL-2, IL-6 and TNF-α levels may be jointly detected to reflect the immune function of patients.

Squeeze the cultivation technique of maxillary teeth after Ⅲ class bone grow forward curative effect and the influence of marginal bone absorption

CHEN Runa, FU Zhennan, ZHANG Peifen, et al

2019, 24(2): 59-62. DOI: 10.12337/zgkqzzxzz.2019.06.003

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Objective： To study the compressive after planting technique of maxillary teeth area Ⅲ bone to grow forward curative effect and the influence of marginal bone absorption. Methods： From March 2012 to March 2013 in our hospital after accepting maxillary teeth area Ⅲ type of bone implant prosthesis treat- ment 86 cases(120) using the implant as research object. With implants as the research unit, the patients were divided into the study group (67 implants) and the control group(53 implants) according to whether they received squeeze implantation. The control group was treated with conventional implant implanta- tion, while the study group was treated with squeeze implantation. Patients in both groups were followed up for 5 years, and the 5-year success rate of implants in the two groups was calculated and compared. In addition, the amount of marginal bone absorption at different postoperative time points was compared be-tween the two groups. Results： The 5-year implant success rate of the study group and the control group was 98.51%(66/67) and 94.34% (50/53), respectively. There was no significant difference between the two groups(all P>0.05). The marginal bone absorption in the study group was(0.38±0.23)mm six months after implant implantation, which was higher than the control group (0.54±0.38)mm, and the difference was sta- tistically significant(P<0.05). 1 year after implantation, 2 years after implantation, and 3 years after im- plantation, the marginal bone absorption in the study group was(1.08±0.64)mm, (1.57±0.60)mm, (1.92± 0.78)mm, respectively. Compared with the control group (1.07±0.59) mm, (1.56±0.72) mm, (1.94±0.85) mm, there was no significant difference(P>0.05). The incidence rates of maxillary sinusitis, surgical site swelling and implant loosening and shedding in the study group were 0.00%(0/67), 1.49% (1/67) and 4.48%(3/67), respectively, which were not significantly different from those in the control group 1.89% (1/ 53), 3.77% (2/53) and 7.55% (4/53), with no statistical significance(all P>0.05). Conclusion： Extrusion for planting area after maxillary teeth Ⅲ kind of bone to grow forward curative effect is better, and effec- tively reduce marginal bone absorption in the short term, but in terms of the forward edge of bone absorp- tion and no significant differences, conventionally grown in clinical practice can be formulated on the ba- sis of the condition of the patients with appropriate ways of planting.

Comparative study of immediate and delayed application of combined implants in patients with periodontitis after periodontal treatment

HUANG Bei, TANG Caomin, LING Xiongjian, et al

2019, 24(2): 63-66. DOI: 10.12337/zgkqzzxzz.2019.06.004

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Objective： To compare the effect of columnar combined implants immediately after treatment of peri- odontal system in patients with periodontitis. Methods： Total of 74 patients(128 teeth) with periodontitis admitted to our hospital from February 2015 to November 2017 were selected. According to the random number table method, it was divided into immediate group(37 cases, 62 teeth) and delayed group(37 cas- es, 66 teeth). Both groups received periodontal system treatment. Immediately, the column-shaped com- bined implant was implanted immediately after the tooth was removed. The delayed group was removed af- ter the tooth was removed. The columnar combination was implanted 6 to 8 months after operation. Im- plants. The depth of probing(PD), modified sulcus bleeding index(m SBI), modified plaque index(m PLI), and 3 months, 6 months, and 12 months after repair were compared immediately after repair in 2 groups. The red aesthetic score(PES) for the month, the stability of the implant 3 months after repair, and the im- plant retention rate within 1 year after repair. Results： There were no significant differences in the PD, m SBI and m PLI between the 2 groups immediately after repair and 3 months after repair (P>0.05). The PES scores at 3 months after immediate group repair were significantly higher than those in the delayed group(P<0.05). There was no significant difference in PES scores between the two groups at 6 months and 12 months after repair(P>0.05). There was no significant difference in the stability of implants between the two groups and the retention rate of implants within one year after repair(P>0.05). Conclusion： Imme-diate planting and delayed planting are equally effective in the treatment of severe periodontitis. The for- mer is better for save patients’visiting time and shorten treatment process. It is worth promoting.

Clinical study on the application of flapless technique in immediate implant restoration of anterior teeth

ZHANG Huajin, HUANG Zhibin, CHEN Weiji, et al

2019, 24(2): 67-70. DOI: 10.12337/zgkqzzxzz.2019.06.005

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Objective： To explore the clinical effect on patients with immediate repair without flap in anterior teeth. Methods： A total of 45 patients undergoing anterior tooth restoration were enrolled in this study. All patients were admitted to the hospital from December 2016 to October 2017. Random number table was used to divide them into 23 cases in the control group and 22 cases in the observation group example. The patients in the control group were repaired with conventional flap inversion technique, and the pa- tients in the observation group were treated with immediate implant repair without flap. The red aesthetic index (PESN), alveolar bone resorption and implant success rate, Repair satisfaction, postoperative stabili- ty(ISQ), and other clinical indicators were compared between the two groups. The clinical effects of the two groups of patients after treatment were evaluated side by side according to the gingival papilla filling index(PIS). At the same time, the adverse symptoms of two groups of patients were recorded and com-pared. Results： Compared with the control group, the corresponding index data of the observation group was higher than that of the control group(P<0.05), and the alveolar bone resorption of the observation group was lower than that of the control group. The results were statistically significant(P<0.05), the suc- cess rate of implantation and the satisfaction degree of repair were higher in the observation group than in the control group(P<0.05). PIS index in observation group 0 and 1 degrees were significantly higher than the control group, the difference was statistically significant(P<0.05). The incidence of adverse symptoms in the observation group was significantly lower than that in the control group, the difference was statisti- cally significant(P<0.05). Conclusion： The effect of immediate implantation without flap is significant, which is beneficial to the patients' soft tissue shape, stability and success rate after implantation, so it is worth popularizing in clinic.

Effect analysis of Bio-Gide membrane on guided bone regeneration in dental implantation

ZOU Ziying

2019, 24(2): 71-73. DOI: 10.12337/zgkqzzxzz.2019.06.006

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Objective： To investigate the effect of Bio-Gide membrane on guided bone regeneration in dental implants. Methods： A total of 160 patients who underwent bone regeneration in our hospital from Janu- ary to February 2018 were enrolled in the study. They were randomly divided into observation group and control group, with 80 cases in each group. The observation group was treated with Bio-Gide membrane, and the control group was treated with Haiao oral prosthetic membrane. The repair success rate, bone graft thickness, bone thickness and adverse reactions were compared between the two groups. Results： The repair success rate of the observation group was 95.00%, which was significantly higher than that of the control group (81.25%) (P<0.05). The bone graft thickness and bone thickness of the observation group were significantly higher than those of the control group(P<0.05). The incidence rate was 8.75%, which was significantly lower than that of the control group(23.75%(P<0.05). Conclusion： Bio-Gide membrane has a definite clinical effect on patients with dental implant-guided bone regeneration, which can improve the success rate of repair and reduce the occurrence of adverse reactions. It is worthy of clini- cal application.

Effect of tooth extraction site preservation on aesthetic effect of dental implant patients

HE Zhiwei

2019, 24(2): 74-76. DOI: 10.12337/zgkqzzxzz.2019.06.007

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Objective： To investigate the effect of tooth extraction point preservation on the aesthetic effect of dental implant patients. Methods： From January 2017 to July 2018, 38 patients with dental implant were randomly divided into two groups: the control group was treated with conventional dental implant after extraction of dental teeth, and the patients in the control group were treated with conventional dental implants after extraction, and the patients in the control group were randomly divided into two groups. Results： Showed that the width, height and density of alveolar bone in the study group were higher than those in the control group, and the lip-palate bone resorption and vertical bone resorption were lower than those in the control group. The degree of beauty was higher than that of the control group(P<0.05). Conclusion： After extraction of teeth, there is a statistical difference between the two groups. Site preservation technology can effectively improve alveolar bone width, height, density, reduce lip and palate bone absorption and vertical bone absorption, provide good conditions for oral implant, and improve the aesthetic effect of patients, which has a certain clinical practical value. It is worth popularizing.

Clinical and radiologic outcomes of conical bone-level implants with internal hexagonal connections:a short-term retrospective study

LIU Xin, ZHANG Xiaocong, HU Mingxuan, et al

2019, 24(2): 77-81. DOI: 10.12337/zgkqzzxzz.2019.06.008

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Objective： To retrospectively evaluate the short-term clinical and radiologic outcomes of a conical bone-level implant with internal hexagonal connection. Methods： A total of 68 conical bone-level im- plants(MIS SEVEN) with internal hexagonal connections inserted into 23 patients were included. Patients were followed up. The survival rate and the marginal bone loss were evaluated by clinical and radiologic examinations. Results： The implant survival rate is 100% within 68 implants. The medial and distal mar- ginal bone loss were(0.02±0.57) mm and (0.14±0.57) mm, respectively, during the average 12.2mouths fol- low-up. Conclusions： High implant survival rate was achieved by this conical bone-level implants with internal hexagonal connections. Marginal bone level was relatively stable. Short-term clinical outcomes were reliable.

Causes and management of mechanical complications in dental implant

CHEN Chuishi, LI Yang

2019, 24(2): 82-85. DOI: 10.12337/zgkqzzxzz.2019.06.009

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Objective： According to explore the causes and treatment of mechanical complications in dental im- plant surgery. Methods： 8 cases of dental implant complications occurred in longgang central hospital, in- cluding 5 cases where the central screw rod of the implant carrier was broken and 3 cases where the base screw was broken when the implant was implanted for immediate repair were collected. According to dif- ferent implant systems and different mechanical complications, corresponding treatment schemes were im- plemented. Result: 7 cases of central screw rod and base screw of the device were completely removed. The postoperative prognosis was good, the implant was not loose, and the subjective satisfaction of the pa- tients was good after the repair. 1 case replanted after the implant was removed, 6 months after the final restorationand were satisfied. Conclusion： Preoperative examination and analysis not only minimize the complications of implantation repair but also improve the success rate of implantation surgery.

Perioperative nursing of CGF in immediate implant placement of maxillary anterior teeth

LUO Weiyan, HONG Yuri, BAO Nianxiang, et al

2019, 24(2): 86-88. DOI: 10.12337/zgkqzzxzz.2019.06.010

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Objective： To summarize the perioperative nursing experience of CGF in immediate implant place- ment, to improve the clinical effect of oral implantation. Methods： 68 cases of missing teeth undergoing immediate implant placement of maxillary anterior teeth were given pre-operative guidance, intraopera- tive cooperation, post-operative and post-restoration nursing. Result: All patients had stable mental health, stable vital signs and smooth implant implantation. After 1 to 3 years follow-up, one patient devel- oped a fistula in the apical region of the implant one year after implantation and got the implant removed. The other patients had healthy bone and soft tissue, and the success rate was more than 98%. Conclusion: Immediate implant placement with perfect medical and nursing cooperation is the guarantee to achieve success and improve patient satisfaction.

The application of six hand nursing in the immediate implants and restoration of edentulous patients

FAN Qinglian, DONG Kai, WANG Weifeng

2019, 24(2): 89-91. DOI: 10.12337/zgkqzzxzz.2019.06.011

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Objective： To summarize the advantages of six-hand care operation in the immediate implants and restoration of edentulous patients, and to seek the best nursing cooperation method. Methods： Twenty patients with complete edentulous jaw were randomly divided into control group(C)and experimental group (P). Four-hand operation and six-hand operation were used to restore the edentulous jaw immediately after implantation. The two groups were compared by the observation and treatment of operation time, patient satisfaction, bacterial detection and surface Plaque Index of prosthesis. Results： The repair operation time of P group, bacterial detection and prosthesis surface plaque index were significantly less than group C(P<0.05), and the patient satisfaction of P group was significantly higher than that in group C (P<0.05). Conclusion： Six hand operation nursing combined with four hand operation can strictly carry out aseptic operation, shorten treatment time, improve work efficiency, improve patient satisfaction and compliance, suitable for the edentulous implantation immediately restoration care cooperation.

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