成骨/破骨细胞轴对糖尿病骨代谢影响的研究进展

doi:10.12337/zgkqzzxzz.2025.04.012

中国口腔种植学杂志 ›› 2025, Vol. 30 ›› Issue (2): 176-179.DOI: 10.12337/zgkqzzxzz.2025.04.012

成骨/破骨细胞轴对糖尿病骨代谢影响的研究进展

王子扬, 马旭东

湖州师范学院医学院（护理学院）313002,浙江

收稿日期:2024-10-15 出版日期:2025-04-30 发布日期:2025-04-21
通讯作者: 马旭东,Email：706532199@qq.com,电话：0572-2559563
作者简介:王子扬本科生在读,研究方向：口腔种植学专业
马旭东硕士研究生、副主任医师,研究方向：口腔临床医学专业（牙体牙髓）

Research progress on the effects of osteoblast/osteoclast axis on bone metabolism in diabetes mellitus

Wang Ziyang, Ma Xudong

Huzhou University School of Medicine&Nursing, Huzhou 313002, Zhejiang, China

Received:2024-10-15 Online:2025-04-30 Published:2025-04-21
Contact: Ma Xudong, Email: 706532199@qq.com, Tel: 0086-572-2559563

摘要/Abstract

摘要： 成骨/破骨细胞轴是骨代谢过程中最关键的调控因子,通过多种信号通路相互作用与调节,共同维持骨组织稳态的动态平衡系统。糖尿病是一种代谢性疾病,以胰岛素生成绝对和相对不足为特征,会导致骨结合效率低和种植修复成功率低。本文综述了成骨/破骨细胞轴的生物学作用及糖尿病对成骨/破骨细胞轴的影响,并总结了成骨/破骨细胞轴调节机制与规律,为改善糖尿病骨结合、提升临床种植成功率提供理论参考。

关键词: 成骨/破骨细胞轴, 糖尿病, 骨结合, 种植修复

Abstract: The osteoblast/osteoclast axis is a key regulatory system in bone metabolism, in which osteoblasts and osteoclasts interact and regulate each other through multiple signaling pathways to maintain skeletal homeostasis. Diabetes mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, leading to impaired osseointegration and reduced success rates of implant therapy. This paper reviews the biological role of the osteoblast/osteoclast axis and the impact of diabetes mellitus on its regulation. It also discusses potential strategies for modulating this axis to enhance osseointegration in diabetic patients and improve the clinical success of implant treatment.

Key words: Osteoblast/osteoclast axis, Diabetes mellitus, Osseointegration, Implant prosthesis

王子扬,马旭东. 成骨/破骨细胞轴对糖尿病骨代谢影响的研究进展[J]. 中国口腔种植学杂志, 2025, 30(2): 176-179. DOI: 10.12337/zgkqzzxzz.2025.04.012

Wang Ziyang, Ma Xudong. Research progress on the effects of osteoblast/osteoclast axis on bone metabolism in diabetes mellitus[J].Chinese Journal of Oral Implantology, 2025, 30(2): 176-179.DOI: 10.12337/zgkqzzxzz.2025.04.012.

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成骨/破骨细胞轴对糖尿病骨代谢影响的研究进展

Research progress on the effects of osteoblast/osteoclast axis on bone metabolism in diabetes mellitus

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