生物材料在口腔骨组织再生中的炎症调节作用及应用

doi:10.12337/zgkqzzxzz.2023.10.002

中国口腔种植学杂志 ›› 2023, Vol. 28 ›› Issue (5): 304-309.DOI: 10.12337/zgkqzzxzz.2023.10.002

生物材料在口腔骨组织再生中的炎症调节作用及应用

张玉峰, 王宇蓝

武汉大学口腔医（学）院种植科口颌系统重建与再生全国重点实验室口腔生物医学教育部重点实验室口腔医学湖北省重点实验室 430079

收稿日期:2023-08-18 出版日期:2023-10-30 发布日期:2023-11-07
通讯作者: 张玉峰,Email：zyf@whu.edu.cn,电话：027-87686600
作者简介:张玉峰武汉大学珞珈特聘教授,二级教授,一级主任医师,博士生导师。现任武汉大学口腔医（学）院副院长,武汉大学口腔先进材料与技术研究所主任,武汉大学泰康生命医学科学中心PI,中华口腔医学会生物医学专业委员会副主任委员、种植专业委员会常委,ITI Fellow,2011年教育部“新世纪优秀人才支持计划”入选者,2020年获国家自然科学基金委杰出青年基金。主要从事牙周和骨再生的机制及应用研究,在该方向已主持国家科技部重点研发计划课题2项（2021、2018）、基金委重点国际（地区）合作项目、湖北省自然科学基金等项目十余项,发表SCI学术论文九十余篇。获湖北省自然科学二等奖及华夏医学科技奖一等奖。爱思唯尔（Elsevier）“中国高被引学者”（2019、2020、2022）。主编英文专著1部,参编专著2部。
基金资助:
国家杰出青年科学基金项目（82025011）

Inflammatory modulation and applications of biomaterials in oral bone regeneration

Zhang Yufeng, Wang Yulan

Department of Implantology, School and Hospital of Stomatology, Wuhan University, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Wuhan 430079, China

Received:2023-08-18 Online:2023-10-30 Published:2023-11-07
Contact: Zhang Yufeng, Email: zyf@whu.edu.cn, Tel: 0086-27-87686600
Supported by:
National Science Fund for Distinguished Young Scholars (82025011)

摘要/Abstract

摘要： 口腔骨再生领域的研究不断取得突破,炎症调控作为其中关键因素逐渐受到重视。炎症的时空调控对于实现骨修复至关重要。在口腔骨再生中,生物材料被用作支架或骨增量材料植入缺损区促进骨组织形成,材料本身的属性可能影响炎症过程及其调控,并且也可作为携带炎症调节药物的载体调节骨再生。深入了解生物材料对炎症反应的调控,可以加速新型骨再生材料的发展。本文围绕口腔骨再生与炎症反应的生物材料研究现状、实验室研究进展进行论述,旨在为临床医生和研究者对再生材料的选用和研发提供理论依据。

关键词: 骨再生, 炎症反应, 生物材料, 巨噬细胞

Abstract: Significant progress has been made in the field of oral bone regeneration, with growing recognition of the pivotal role played by inflammation regulation. Temporal and contextual regulation of inflammation is essential for achieving successful bone repair. In the context of oral bone regeneration, biomaterials are employed as scaffolds/bone grafts to promote bone tissue formation in defect areas. The intrinsic properties of biomaterials may impact the inflammatory process and its regulation. Additionally, biomaterials can serve as carriers for immuno-modulatory drugs, further influencing bone regeneration. A comprehensive understanding of how biomaterials modulate inflammatory responses holds the potential to accelerate the development of novel bone regeneration materials. This review provides an overview of the current status of research on biomaterials in the context of oral bone regeneration and inflammation response, summarizing the laboratory advancements. The aim is to provide clinicians and researchers with a theoretical foundation for the selection and development of regenerative materials.

Key words: Bone regeneration, Inflammation response, Biomaterials, Macrophages

张玉峰,等王宇蓝. 生物材料在口腔骨组织再生中的炎症调节作用及应用[J]. 中国口腔种植学杂志, 2023, 28(5): 304-309. DOI: 10.12337/zgkqzzxzz.2023.10.002

Zhang Yufeng, Wang Yulan. Inflammatory modulation and applications of biomaterials in oral bone regeneration[J].Chinese Journal of Oral Implantology, 2023, 28(5): 304-309.DOI: 10.12337/zgkqzzxzz.2023.10.002.

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生物材料在口腔骨组织再生中的炎症调节作用及应用

Inflammatory modulation and applications of biomaterials in oral bone regeneration

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