种植体周炎大鼠模型的研究进展

doi:10.12337/zgkqzzxzz.2022.02.010

中国口腔种植学杂志 ›› 2022, Vol. 27 ›› Issue (1): 50-53.DOI: 10.12337/zgkqzzxzz.2022.02.010

种植体周炎大鼠模型的研究进展

党如意, 季平

重庆医科大学附属口腔医院种植科口腔疾病与生物医学重庆市重点实验室重庆市高校市级口腔生物医学工程重点实验室 401147

收稿日期:2021-09-30 发布日期:2022-03-09
通讯作者: 季平,Email: jiping@hospital.cqmu.edu.cn,电话：023-88602360

Research advance on rat models of peri-implantitis

Dang Ruyi, Ji Ping

Department of Implantology, Stomatological Hospital of Chongqing Medical University & Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences & Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China

Received:2021-09-30 Published:2022-03-09
Contact: Ji Ping, Email: jiping@hospital.cqmu.edu.cn, Tel: 0086-23-88602360

摘要/Abstract

摘要： 种植体周炎是导致种植失败的主要原因,但目前种植体周炎的发病机制尚不明确、治疗方法也不理想。动物模型是研究疾病发病机制和治疗方法的重要工具,大鼠具有便宜、饲养成本低、相关分子生物学试剂完善等优点。因此本文将从种植体的设计、种植体植入时机和位点、种植体周炎的诱导方式三个方面进行种植体周炎大鼠模型的综述,旨在帮助研究者选择合适的建模方法。总的来说,选择种植体加愈合基台的设计在上颌第一磨牙拔牙后3周或1个月植入种植体是比较符合临床的方法。诱导种植体周炎的方式包括致病菌接种法、丝线结扎法、脂多糖注射法。这三种方法各有优缺点,可依据研究者不同目的而做不同的选择。目前建模相关研究对于种植体植入的种植窝洞预备尺寸和扩孔钻转速描述尚不清晰,需要进一步研究。

关键词: 种植体周炎, 疾病模型, 大鼠

Abstract: Peri-implantitis is the main cause of implant failure. However, the pathogenesis of peri-implantitis is still unclear. Effective treatments are also deficient. Animal models are important tools to explore pathogenesis and effective treatment methods. SD (Sprague-Dawley) rats are cheap and have a low cost of feeding. Biological reagents compatible with SD rats are also abundant. This article summarized three important aspects including design of the implant, time and site of implants, and methods of causing peri-implantitis to give property advice to researchers. In summary, It is close to the clinic to choose the design of the implant and healing abutment, implanting site of first molar region of maxillary, and implanting time of 3 weeks or 1 month after tooth extraction. Methods of causing peri-implantitis include inoculation of pathogenic bacteria, ligation of silk thread, and injection of lipopolysaccharide, which have their respective pros and cons. Researchers could choose different methods according to different purposes. At present, the hole preparation size and reaming drill speed for implant placement are not described clearly, which needs further research.

Key words: Peri-implantitis, Disease models, Rats

党如意,等季平. 种植体周炎大鼠模型的研究进展[J]. 中国口腔种植学杂志, 2022, 27(1): 50-53. DOI: 10.12337/zgkqzzxzz.2022.02.010

Dang Ruyi, Ji Ping. Research advance on rat models of peri-implantitis[J].Chinese Journal of Oral Implantology, 2022, 27(1): 50-53.DOI: 10.12337/zgkqzzxzz.2022.02.010.

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种植体周炎大鼠模型的研究进展

Research advance on rat models of peri-implantitis

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