外胚层发育不良重度缺牙青少年种植干预的研究现状

doi:10.12337/zgkqzzxzz.2024.06.008

中国口腔种植学杂志 ›› 2024, Vol. 29 ›› Issue (3): 236-241.DOI: 10.12337/zgkqzzxzz.2024.06.008

• “先天缺牙的相关治疗及进展”重点栏目 • 上一篇下一篇

外胚层发育不良重度缺牙青少年种植干预的研究现状

苏冠宇, 沈意涵, 吴轶群, 王凤

上海交通大学医学院附属第九人民医院口腔第二门诊部上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所,201999

收稿日期:2024-03-12 出版日期:2024-06-30 发布日期:2024-06-28
通讯作者: 王凤,Email：diana_wangfeng@aliyun.com,电话：021-56152705
作者简介:苏冠宇硕士研究生在读,研究方向：先天性牙缺失的种植修复;王凤主任医师、博士,研究方向：口腔种植临床与基础研究
基金资助:
上海交通大学医学院附属第九人民医院生物样本库（YBKB202101）

Current research status of implant intervention in adolescents with severe tooth loss due to ectodermal dysplasia

Su Guanyu, Shen Yihan, Wu Yiqun, Wang Feng

Department of Second Dental Center, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 201999, China

Received:2024-03-12 Online:2024-06-30 Published:2024-06-28
Contact: Wang Feng, Email: diana_wangfeng@aliyun.com, Tel: 0086-21-56152705
Supported by:
Biobank of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (YBKB202101)

摘要/Abstract

摘要： 缺牙是青少年口腔颌面部常见的发育畸形。外胚层发育不良（ectodermal dysplasia, ED）是造成青少年重度缺牙的最主要原因。对重度缺牙的青少年进行干预可能有利于患者咀嚼、语言功能的恢复以及颌面部的美观。种植义齿修复相比于传统可摘义齿具有更好的固位和稳定性。本文对ED患者青少年时期种植的可行性进行分析,着重介绍这一类特殊患者种植修复的考量因素以及常见方法;同时对该领域的进一步研究进行展望。

关键词: 种植, 重度缺牙, 外胚层发育不良, 青少年

Abstract: Tooth agenesis is a typical developmental abnormality in the oral and maxillofacial region among teenagers. Ectodermal dysplasia(ED) is the primary cause of severe tooth agenesis in adolescents. Teenagers with severe tooth agenesis benefit from implant intervention for the possibility of regaining masticatory function and speech function, as well as maintaining a pleasing facial appearance. In terms of retention and stability, implant-supported dentures for teenagers outperform conventional removable dentures. This review elaborates on the feasibility of implant placement in teenagers with ED, focusing on the considerations of implant placement and common methods for this special group of patients. Lastly, prospects for further study in this field are highlighted.

Key words: Implant, Severe tooth agenesis, Ectodermal dysplasia, Teenagers

苏冠宇,沈意涵,吴轶群,等. 外胚层发育不良重度缺牙青少年种植干预的研究现状[J]. 中国口腔种植学杂志, 2024, 29(3): 236-241. DOI: 10.12337/zgkqzzxzz.2024.06.008

Su Guanyu, Shen Yihan, Wu Yiqun, Wang Feng. Current research status of implant intervention in adolescents with severe tooth loss due to ectodermal dysplasia[J].Chinese Journal of Oral Implantology, 2024, 29(3): 236-241.DOI: 10.12337/zgkqzzxzz.2024.06.008.

参考文献

[1] Elagib M, Alqaysi M, Almushayt M, et al.Dental implants in growing patients: a systematic review and meta-analysis[J]. Technol Health Care, 2023, 31(3):1051-1064. DOI: 10.3233/THC-220581.
[2] Bohner L, Hanisch M, Kleinheinz J, et al.Dental implants in growing patients: a systematic review[J]. Br J Oral Maxillofac Surg, 2019, 57(5):397-406. DOI: 10.1016/j.bjoms.2019.04.011.
[3] Çolak M.An evaluation of bone mineral density using cone beam computed tomography in patients with ectodermal dysplasia: a retrospective study at a single center in Turkey[J]. Med Sci Monit, 2019, 25:3503-3509. DOI: 10.12659/MSM.914405.
[4] Clarke A, Phillips DI, Brown R, et al.Clinical aspects of X-linked hypohidrotic ectodermal dysplasia[J]. Arch Dis Child, 1987, 62(10):989-996. DOI: 10.1136/adc.62.10.989.
[5] Kargül B, Alcan T, Kabalay U, et al.Hypohidrotic ectodermal dysplasia: dental, clinical, genetic and dermatoglyphic findings of three cases[J]. J Clin Pediatr Dent, 2001, 26(1):5-12. DOI: 10.17796/jcpd.26.1.g156r02u66w30729.
[6] Cezária Triches T, Ximenes M, Oliveira de Souza JG, et al. Implant-supported oral rehabilitation in child with ectodermal dysplasia - 4-year follow-up[J]. Bull Tokyo Dent Coll, 2017, 58(1):49-56. DOI: 10.2209/tdcpublication.2016-0012.
[7] Chrcanovic BR.Dental implants in patients with ectodermal dysplasia: a systematic review[J]. J Craniomaxillofac Surg, 2018, 46(8):1211-1217. DOI: 10.1016/j.jcms.2018.05.038.
[8] Montanari M, Grande F, Lepidi L, et al.Rehabilitation with implant-supported overdentures in preteens patients with ectodermal dysplasia: a cohort study[J]. Clin Implant Dent Relat Res, 2023, 25(6):1187-1196. DOI: 10.1111/cid.13258.
[9] Knobloch LA, Larsen PE, Saponaro PC, et al.Early implant placement for a patient with ectodermal dysplasia: thirteen years of clinical care[J]. J Prosthet Dent, 2018, 119(5):702-709. DOI: 10.1016/j.prosdent.2017.08.015.
[10] 吕红, 刘清辉, 李佳芙, 等. 外胚层发育不全患者牙列缺损修复1例及文献回顾[J]. 口腔疾病防治
2024, 32(4):287-295. DOI: 10.12016/j.issn.2096-1456.2024.04.007.
[11] 孟晶, 屈志国, 赵亚东, 等. 多学科联合序列治疗Ⅰ型先天缺牙伴骨性Ⅲ类反。。。1例[J]. 实用口腔医学杂志, 2022, 38(06):813-816.
[12] 张庆福, 刘国勤, 刘刚, 等. 自体骨移植与引导骨再生在外胚层发育不全综合征种植修复中的应用[J]. 口腔颌面外科杂志, 2014, (6):443-447. DOI: 10.3969/j.issn.1005-4979.2014.06.010.
[13] 葛严军, 单小峰, 李曼, 等. 外胚层发育不全患者上下颌骨重建及全口种植固定修复[J]. 中国口腔种植学杂志, 2021, 26(1):44-46. DOI: 10.12337/zgkqzzxzz.2021.02.010.
[14] 宋应亮, 马兆峰, 李德华, 等. 种植固位体在先天性全口缺牙患者义齿修复中的应用[J]. 临床口腔医学杂志
2004, 20(11):680-681. DOI: 10.3969/j.issn.1003-1634.2004.11.016.
[15] 李娇, 张杰, 李梦雪, 等. 先天缺牙患儿活动和种植修复1例[J]. 口腔医学研究, 2023, 39(1):89-91. DOI: 10.13701/j.cnki.kqyxyj.2023.01.017.
[16] Dupré N, Fournier B, Gondel O, et al.Reduced bone dimension in patients affected by oligodontia: a retrospective study on maxillary and mandibular CBCT[J]. J Clin Periodontol, 2023, 50(12):1590-1600. DOI: 10.1111/jcpe.13866.
[17] Johnson EL, Roberts MW, Guckes AD, et al.Analysis of craniofacial development in children with hypohidrotic ectodermal dysplasia[J]. Am J Med Genet, 2002, 112(4):327-334. DOI: 10.1002/ajmg.10654.
[18] Dhima M, Salinas TJ, Cofer SA, et al.Rehabilitation of medically complex ectodermal dysplasia with novel surgical and prosthodontic protocols[J]. Int J Oral Maxillofac Surg, 2014, 43(3):301-304. DOI: 10.1016/j.ijom.2013.08.004.
[19] Mello BZ, Silva TC, Rios D, et al.Mini-implants: alternative for oral rehabilitation of a child with ectodermal dysplasia[J]. Braz Dent J, 2015, 26(1):75-78. DOI: 10.1590/0103-6440201300111.
[20] Toomarian L, Ardakani MR, Ramezani J, et al.Using implants for prosthodontic rehabilitation of a 4-year-old with ectodermal dysplasia[J]. Gen Dent, 2014, 62(5):e1-e5.
[21] Alcan T, Basa S, Kargül B.Growth analysis of a patient with ectodermal dysplasia treated with endosseous implants: 6-year follow-up[J]. J Oral Rehabil, 2006, 33(3):175-182. DOI: 10.1111/j.1365-2842.2005.01566.x.
[22] Liu Y, Tang C.Interdisciplinary treatment with implant-supported prostheses for an adolescent with ectodermal dysplasia: a clinical report[J]. J Prosthet Dent, 2020, 123(5):655-660. DOI: 10.1016/j.prosdent.2019.07.006.
[23] Mankani N, Chowdhary R, Patil BA, et al.Osseointegrated dental implants in growing children: a literature review[J]. J Oral Implantol, 2014, 40(5):627-631. DOI: 10.1563/AAID-JOI-D-11-00186.
[24] Escobar V, Epker BN.Alveolar bone growth in response to endosteal implants in two patients with ectodermal dysplasia[J]. Int J Oral Maxillofac Surg, 1998, 27(6):445-447. DOI: 10.1016/s0901-5027(98)80034-9.
[25] Bergendal B, Bjerklin K, Bergendal T, et al.Dental implant therapy for a child with X-linked hypohidrotic ectodermal dysplasia--three decades of managed care[J]. Int J Prosthodont, 2015, 28(4):348-356. DOI: 10.11607/ijp.4242.
[26] Montanari M, Grande F, Lepidi L, et al.Rehabilitation with implant-supported overdentures in preteens patients with ectodermal dysplasia: a cohort study[J]. Clin Implant Dent Relat Res, 2023, 25(6):1187-1196. DOI: 10.1111/cid.13258.
[27] Filius MA, Vissink A, Raghoebar GM, et al.Implant-retained overdentures for young children with severe oligodontia: a series of four cases[J]. J Oral Maxillofac Surg, 2014, 72(9):1684-1690. DOI: 10.1016/j.joms.2014.04.034.
[28] Wang Y, He J, Decker AM, et al.Clinical outcomes of implant therapy in ectodermal dysplasia patients: a systematic review[J]. Int J Oral Maxillofac Surg, 2016, 45(8):1035-1043. DOI: 10.1016/j.ijom.2016.03.011.
[29] Mishra SK, Chowdhary N, Chowdhary R.Dental implants in growing children[J]. J Indian Soc Pedod Prev Dent, 2013, 31(1):3-9. DOI: 10.4103/0970-4388.112392.
[30] Op Heij DG, Opdebeeck H, van Steenberghe D, et al. Age as compromising factor for implant insertion[J]. Periodontol 2000, 2003, 33:172-184. DOI: 10.1046/j.0906-6713.2003.03314.x.
[31] Klineberg I, Cameron A, Whittle T, et al.Rehabilitation of children with ectodermal dysplasia. Part 1: An international delphi study[J]. Int J Oral Maxillofac Implants, 2013, 28(4):1090-1100. DOI: 10.11607/jomi.2980.
[32] Schnabl D, Gerhard S, Biedermann R, et al.Dental management and prosthetic rehabilitation of patients suffering from hypohidrotic ectodermal dysplasia: a report of two case histories[J]. Int J Prosthodont, 2018, 31(6):552-557. DOI: 10.11607/ijp.5857.
[33] Huang PY, Driscoll CF.From childhood to adulthood: oral rehabilitation of a patient with ectodermal dysplasia[J]. J Prosthet Dent, 2014, 112(3):439-443. DOI: 10.1016/j.prosdent.2014.04.012.
[34] Casaña-Ruiz MD, Català-Pizarro M, Borrás-Aviñó C, et al.Implants as a treatment alternative in children with multiple agnesia: systematic review and meta-analysis[J]. J Clin Exp Dent, 2023, 15(4):e324-e337. DOI: 10.4317/jced.60168.
[35] Filius M, Vissink A, Cune MS, et al.Long-term implant performance and patients' satisfaction in oligodontia[J]. J Dent, 2018, 71:18-24. DOI: 10.1016/j.jdent.2018.01.007.
[36] Heij DG, Opdebeeck H, van Steenberghe D, et al. Facial development, continuous tooth eruption, and mesial drift as compromising factors for implant placement[J]. Int J Oral Maxillofac Implants, 2006, 21(6):867-878.
[37] Smith RA, Vargervik K, Kearns G, et al.Placement of an endosseous implant in a growing child with ectodermal dysplasia[J]. Oral Surg Oral Med Oral Pathol, 1993, 75(6):669-673. DOI: 10.1016/0030-4220(93)90419-5.
[38] Lambert F, Botilde G, Lecloux G, et al.Effectiveness of temporary implants in teenage patients: a prospective clinical trial[J]. Clin Oral Implants Res, 2017, 28(9):1152-1157. DOI: 10.1111/clr.12931.
[39] Thilander B, Odman J, Gröndahl K, et al.Aspects on osseointegrated implants inserted in growing jaws. A biometric and radiographic study in the young pig[J]. Eur J Orthod, 1992, 14(2):99-109. DOI: 10.1093/ejo/14.2.99.
[40] Machado M, Wallace C, Austin B, et al.Rehabilitation of ectodermal dysplasia patients presenting with hypodontia: outcomes of implant rehabilitation part 1[J]. J Prosthodont Res, 2018, 62(4):473-478. DOI: 10.1016/j.jpor.2018.07.001.
[41] Zhu Q, Jiang Y, Yu J, et al.Implant restoration of hypodontia resulting from ectodermal dysplasia: a case report[J]. J Int Med Res, 2021, 49(12):3000605211067411. DOI: 10.1177/03000605211067411.
[42] Güler N, Cildir S, Iseri U, et al.Hypohidrotic ectodermal dysplasia with bilateral impacted teeth at the coronoid process: a case rehabilitated with mini dental implants[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005, 99(5):e34-e38. DOI: 10.1016/j.tripleo.2004.12.014.
[43] Wang H, Hung K, Zhao K, et al.Anatomical analysis of zygomatic bone in ectodermal dysplasia patients with oligodontia[J]. Clin Implant Dent Relat Res, 2019, 21(2):310-316. DOI: 10.1111/cid.12731.
[44] Sun X, Yang J, Ma X, et al.Complex rehabilitation for an adolescent with ectodermal dysplasia-a 10-year follow-up[J]. J Prosthodont, 2021, 30(1):7-12. DOI: 10.1111/jopr.13238.
[45] Ritto FG, Medeiros PJ, de Oliveira Mussel RL, et al. Rehabilitation of an adolescent with ectodermal dysplasia. two-stage orthognathic, graft, and implant surgery: case report[J]. Implant Dent, 2009, 18(4):311-315. DOI: 10.1097/ID.0b013e3181ad181e.
[46] Bohner L, Vinayahalingam S, Kleinheinz J, et al.Digital implant planning in patients with ectodermal dysplasia: clinical report[J]. Int J Environ Res Public Health, 2022, 19(3):1489. DOI: 10.3390/ijerph19031489.
[47] Wittneben JG, Joda T, Weber HP, et al.Screw retained vs. cement retained implant-supported fixed dental prosthesis[J]. Periodontol 2000, 2017, 73(1):141-151. DOI: 10.1111/prd.12168.
[48] Kilic S, Altintas SH, Yilmaz Altintas N, et al.Six-year survival of a mini dental implant-retained overdenture in a child with ectodermal dysplasia[J]. J Prosthodont, 2017, 26(1):70-74. DOI: 10.1111/jopr.12366.
[49] Aparicio C, Manresa C, Francisco K, et al.Zygomatic implants: indications, techniques and outcomes, and the zygomatic success code[J]. Periodontol 2000, 2014, 66(1):41-58. DOI: 10.1111/prd.12038.
[50] Oesterle LJ, Cronin RJ Jr.Adult growth, aging, and the single-tooth implant[J]. Int J Oral Maxillofac Implants, 2000, 15(2):252-260.
[51] Thilander B.Dentoalveolar development in subjects with normal occlusion. A longitudinal study between the ages of 5 and 31 years[J]. Eur J Orthod, 2009, 31(2):109-120. DOI: 10.1093/ejo/cjn124.
[52] Schnabl D, Grunert I, Schmuth M, et al.Prosthetic rehabilitation of patients with hypohidrotic ectodermal dysplasia: a systematic review[J]. J Oral Rehabil, 2018, 45(7):555-570. DOI: 10.1111/joor.12638.
[53] Cherian JM, Samuel S, Sabu AM, et al.Dental implants in growing patients: a quality assessment of systematic reviews[J]. J Oral Biol Craniofac Res, 2023, 13(5):610-615. DOI: 10.1016/j.jobcr.2023.07.004.
[54] Björk A, Skieller V.Growth of the maxilla in three dimensions as revealed radiographically by the implant method[J]. Br J Orthod, 1977, 4(2):53-64. DOI: 10.1179/bjo.4.2.53.
[55] Cronin RJ Jr, Oesterle LJ, Ranly DM.Mandibular implants and the growing patient[J]. Int J Oral Maxillofac Implants, 1994, 9(1):55-62.
[56] Solow B.The dentoalveolar compensatory mechanism: background and clinical implications[J]. Br J Orthod, 1980, 7(3):145-161. DOI: 10.1179/bjo.7.3.145.

外胚层发育不良重度缺牙青少年种植干预的研究现状

Current research status of implant intervention in adolescents with severe tooth loss due to ectodermal dysplasia

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	吴轶群, 王凤. 先天缺牙患者的种植治疗[J]. 中国口腔种植学杂志, 2024, 29(3): 204-211.
[2]	耿晨昕, 刘洋, 韩冬. 先天性缺牙治疗的研究进展[J]. 中国口腔种植学杂志, 2024, 29(3): 224-230.
[3]	王明熙, 高姗, 王龙, 周永淼, 汤春波. 外胚层发育不良患者的口腔种植治疗策略[J]. 中国口腔种植学杂志, 2024, 29(3): 231-235.
[4]	赵昱, 昝冰欣, 代庆刚. 先天缺牙种植体留存率的系统性文献回顾[J]. 中国口腔种植学杂志, 2024, 29(3): 242-251.
[5]	陈江, 丘雨蓓. 数字化技术在口腔种植骨增量中的应用及研究进展[J]. 中国口腔种植学杂志, 2024, 29(3): 252-257.
[6]	赵宁, 李晓杰, 寇霓, 马国武. 数字化辅助美学区穿埋伏牙即刻种植一例[J]. 中国口腔种植学杂志, 2024, 29(3): 266-271.
[7]	蒋娟娜, 李俊满, 陈琳, 谢亮焜. 自体骨-异种骨混合的钛网支撑的引导骨再生伴角化龈增量的美学区连续牙列缺损种植修复一例[J]. 中国口腔种植学杂志, 2024, 29(3): 272-276.
[8]	王铭阳, 黄海涛. 质子泵抑制剂对口腔种植体骨结合影响的研究进展[J]. 中国口腔种植学杂志, 2024, 29(3): 277-283.
[9]	陈佳欣, 顾新华. 种植体周软组织增量材料的研究进展[J]. 中国口腔种植学杂志, 2024, 29(3): 284-288.
[10]	夏海斌, 徐珺怡. 上颌窦底内提升同期植入种植体的研究现状[J]. 中国口腔种植学杂志, 2024, 29(2): 109-117.
[11]	李效宇, 于欢, 孟维艳. 施耐德膜增厚对穿牙槽嵴上颌窦底提升影响的研究进展[J]. 中国口腔种植学杂志, 2024, 29(2): 127-132.
[12]	王琦, 杨波, 刘璐, 李翠英, 王心彧. 不同颌骨密度下种植体设计对其骨界面应力分布影响的有限元分析[J]. 中国口腔种植学杂志, 2024, 29(2): 159-168.
[13]	赵文博, 李昕茹, 苏航, 滕微微, 蔡雯昱, 周立波. 人工智能在下颌磨牙区即刻种植测量分析中的可行性研究[J]. 中国口腔种植学杂志, 2024, 29(2): 178-183.
[14]	赵克, 朱洁莹, 顾新华. 实体器官移植患者的口腔种植治疗研究进展[J]. 中国口腔种植学杂志, 2024, 29(2): 190-194.
[15]	陈江, 何凯讯. 口腔咬合临床应用的现状与进展[J]. 中国口腔种植学杂志, 2024, 29(1): 3-8.