Abstract: Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are the most common surgical procedures for soft and hard tissue regeneration in the field of dentistry. After decades of clinical applications of these techniques, challenges of esthetics and function rehabilitation have triggered the development of numerous bone or soft tissue subsitutes. However, the existing allograft or xenograft materials still carry potential risks of cross-infection and immune rejection,and for barrier membranes, acceptable mechanical strength and biodegradation may not be both achieved in most cases. These years, autologous platelet concentrates have emerged as innovative graft materials and come into common use due to the easiness of preparation, excellent biocompatibility and regenerative properties. Concentrated growth factor (CGF) is a new generation of platelet concentrates. The fibrin matrix scaffold inside is much stiffer than its previous generations, while the richer growth factors, cytokines and cells it contains better promote cell proliferation and differentiation, extracellular matrix synthesis and angiogenesis. This article reviewed the characteristics of CGF in terms of bone and soft tissue augmentation in oral cavity and its related research progress in dental clinics.

Key words: Concentrated growth factor, Bone augmentation, Dental implant, Periodontal tissue regeneration