Research progress of zinc-based biodegradable metals for biological barrier membrane

doi:10.12337/zgkqzzxzz.2023.02.004

Abstract

Abstract: Guided Bone Regeneration (GBR) is the most common bone augmentation procedure in implant dentistry, and the effect of bone augmentation is determined by the material properties of the biological barrier membranes. However, are current biological barrier membranes are insufficient for all clinical requirements, including excellent biocompatibility, high mechanical properties, controllable degradation behavior, superior bioactivity, and easy clinical management. It is required to develop and investigate a novel material for the biological barrier membrane. Biodegradable metals (BMs) refer to metals that are intended to degrade in vivo. Among them, zinc(Zn)-based BMs are regarded as a novel generation of biological barrier membrane materials due to their excellent material properties. Nevertheless, Zn-based biological barrier membranes have been still in the stage of research and development. Based on our previous research studies and considering the future clinical applications, this paper systematically reviewed the research status and drawbacks of Zn-based biological barrier membranes in terms of four aspects: biocompatibility, mechanical properties, biodegradability, and bioactivity, providing scientific evidence to promote its clinical transformation.

Key words: Biological barrier membrane, Biodegradable metals, Mechanical property, Degradation behavior, Biological response

Xu Shulan, Chen Jiahao. Research progress of zinc-based biodegradable metals for biological barrier membrane[J]. Chinese Journal of Oral Implantology, 2023, 28(1): 19-25.

References

[1] Brügger OE, Bornstein MM, Kuchler U, et al.Implant therapy in a surgical specialty clinic: an analysis of patients, indications, surgical procedures, risk factors, and early failures[J]. Int J Oral Maxillofac Implants, 2015, 30(1):151-160. DOI: 10.11607/jomi.3769.
[2] 张富贵, 宿玉成, 邱立新, 等. 牙槽骨缺损骨增量手术方案的专家共识[J]. 口腔疾病防治, 2022, 30(4):229-236. DOI: 10.12016/j.issn.2096-1456.2022.04.001.
[3] Wang HL, Boyapati L."PASS" principles for predictable bone regeneration[J]. Implant Dent, 2006, 15(1):8-17. DOI: 10.1097/01.id.0000204762.39826.0f.
[4] Williams DF.On the nature of biomaterials[J]. Biomaterials, 2009, 30(30):5897-5909. DOI: 10.1016/j.biomaterials.2009.07.027.
[5] 何逸恒, 程鸣威, 朱培君, 等. 电活性生物膜促进大鼠的体内成骨[J]. 中国组织工程研究, 2022, 26(28):4446-4451.
[6] 许言, 李平, 赖春花, 等. 血管化骨再生中压电生物材料的应用[J]. 中国组织工程研究, 2023, 27(7):1126-1132.
[7] 朱培君, 赖春花, 程鸣威, 等. 电活性生物膜通过调控巨噬细胞极化促进骨再生修复的体外研究[J]. 实用医学杂志, 2021, 37(10):1257-1262. DOI: 10.3969/j.issn.1006-5725.2021.10.005.
[8] Soldatos NK, Stylianou P, Koidou VP, et al.Limitations and options using resorbable versus nonresorbable membranes for successful guided bone regeneration[J]. Quintessence Int, 2017, 48(2):131-147. DOI: 10.3290/j.qi.a37133.
[9] Zhang W, Li P, Shen G, et al.Appropriately adapted properties of hot-extruded Zn-0.5Cu-xFe alloys aimed for biodegradable guided bone regeneration membrane application[J]. Bioact Mater, 2021, 6(4):975-989. DOI: 10.1016/j.bioactmat.2020.09.019.
[10] Li P, Zhang W, Dai J, et al.Investigation of zinc-copper alloys as potential materials for craniomaxillofacial osteosynthesis implants[J]. Mater Sci Eng C Mater Biol Appl, 2019, 103:109826. DOI: 10.1016/j.msec.2019.109826.
[11] Li P, Schille C, Schweizer E, et al.Mechanical characteristics, in vitro degradation, cytotoxicity, and antibacterial evaluation of Zn-4.0Ag alloy as a biodegradable material[J]. Int J Mol Sci, 2018, 19(3):755. DOI: 10.3390/ijms19030755.
[12] Čapek J, Kubásek J, Pinc J, et al.Microstructural, mechanical, in vitro corrosion and biological characterization of an extruded Zn-0.8Mg-0.2Sr (wt%) as an absorbable material[J]. Mater Sci Eng C Mater Biol Appl, 2021, 122:111924. DOI: 10.1016/j.msec.2021.111924.
[13] Li P, Qian J, Zhang W, et al.Improved biodegradability of zinc and its alloys by sandblasting treatment[J]. Surf Coat Technol, 2020, 405(18): 126678. DOI: 10.1016/j.surfcoat.2020.126678.
[14] Li P, Zhang W, Spintzyk S, et al.Impact of sterilization treatments on biodegradability and cytocompatibility of zinc-based implant materials[J]. Mater Sci Eng C Mater Biol Appl, 2021, 130:112430. DOI: 10.1016/j.msec.2021.112430.
[15] Li P, Schille C, Schweizer E, et al.Selection of extraction medium influences cytotoxicity of zinc and its alloys[J]. Acta Biomater, 2019, 98:235-245. DOI: 10.1016/j.actbio.2019.03.013.
[16] Zhu P, Chen J, Li P, et al.Limitation of water-soluble tetrazolium salt for the cytocompatibility evaluation of zinc-based metals[J]. Materials (Basel), 2021, 14(21):6247. DOI: 10.3390/ma14216247.
[17] Li P, Dai J, Schweizer E, et al.Response of human periosteal cells to degradation products of zinc and its alloy[J]. Mater Sci Eng C Mater Biol Appl, 2020, 108:110208. DOI: 10.1016/j.msec.2019.110208.
[18] Xu Y, Xu Y, Zhang W, et al.Biodegradable Zn-Cu-Fe alloy as a promising material for craniomaxillofacial implants: an in vitro investigation into degradation behavior, cytotoxicity, and hemocompatibility[J]. Front Chem, 2022, 10:860040. DOI: 10.3389/fchem.2022.860040.
[19] Zhang W, Li P, Neumann B, et al.Chandler-Loop surveyed blood compatibility and dynamic blood triggered degradation behavior of Zn-4Cu alloy and Zn[J]. Mater Sci Eng C Mater Biol Appl, 2021, 119:111594. DOI: 10.1016/j.msec.2020.111594.
[20] Yin YX, Zhou C, Shi YP, et al.Hemocompatibility of biodegradable Zn-0.8 wt% (Cu, Mn, Li) alloys[J]. Mater Sci Eng C Mater Biol Appl, 2019, 104:109896. DOI: 10.1016/j.msec.2019.109896.
[21] Li P, Schille C, Schweizer E, et al.Evaluation of a Zn-2Ag-1.8Au-0.2V alloy for absorbable biocompatible materials[J]. Materials (Basel), 2019, 13(1):56. DOI: 10.3390/ma13010056.
[22] Mostaed E, Sikora-Jasinska M, Drelich JW, et al.Zinc-based alloys for degradable vascular stent applications[J]. Acta Biomater, 2018, 71:1-23. DOI: 10.1016/j.actbio.2018.03.005.
[23] Chiapasco M, Zaniboni M. Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: a systematic review[J]. Clin Oral Implants Res, 2009, 20 Suppl 4:113-123. DOI: 10.1111/j.1600-0501.2009.01781.x.
[24] Lin J, Tong X, Shi Z, et al.A biodegradable Zn-1Cu-0.1Ti alloy with antibacterial properties for orthopedic applications[J]. Acta Biomater, 2020, 106:410-427. DOI: 10.1016/j.actbio.2020.02.017.
[25] Tang Z, Niu J, Huang H, et al.Potential biodegradable Zn-Cu binary alloys developed for cardiovascular implant applications[J]. J Mech Behav Biomed Mater, 2017, 72:182-191. DOI: 10.1016/j.jmbbm.2017.05.013.
[26] Seil JT, Webster TJ.Reduced Staphylococcus aureus proliferation and biofilm formation on zinc oxide nanoparticle PVC composite surfaces[J]. Acta Biomater, 2011, 7(6):2579-2584. DOI: 10.1016/j.actbio.2011.03.018.
[27] Spaey YJ, Bettens RM, Mommaerts MY, et al.A prospective study on infectious complications in orthognathic surgery[J]. J Craniomaxillofac Surg, 2005, 33(1):24-29. DOI: 10.1016/j.jcms.2004.06.008.
[28] Pye AD, Lockhart DE, Dawson MP, et al.A review of dental implants and infection[J]. J Hosp Infect, 2009, 72(2):104-110. DOI: 10.1016/j.jhin.2009.02.010.
[29] Zhang HY, Jiang HB, Ryu JH, et al.Comparing properties of variable pore-sized 3D-printed PLA membrane with conventional PLA membrane for guided bone/tissue regeneration[J]. Materials (Basel), 2019, 12(10):1718. DOI: 10.3390/ma12101718.
[30] Zellin G, Linde A.Effects of different osteopromotive membrane porosities on experimental bone neogenesis in rats[J]. Biomaterials, 1996, 17(7):695-702. DOI: 10.1016/0142-9612(96)86739-1.
[31] Gutta R, Baker RA, Bartolucci AA, et al.Barrier membranes used for ridge augmentation: is there an optimal pore size?[J]. J Oral Maxillofac Surg, 2009, 67(6):1218-1225. DOI: 10.1016/j.joms.2008.11.022.
[32] Caballé-Serrano J, Munar-Frau A, Ortiz-Puigpelat O, et al.On the search of the ideal barrier membrane for guided bone regeneration[J]. J Clin Exp Dent, 2018, 10(5):e477-e483. DOI: 10.4317/jced.54767.
[33] Guo H, Xia D, Zheng Y, et al.A pure zinc membrane with degradability and osteogenesis promotion for guided bone regeneration: in vitro and in vivo studies[J]. Acta Biomater, 2020, 106:396-409. DOI: 10.1016/j.actbio.2020.02.024.
[34] Zhu D, Cockerill I, Su Y, et al.Mechanical strength, biodegradation, and in vitro and in vivo biocompatibility of Zn biomaterials[J]. ACS Appl Mater Interfaces, 2019, 11(7):6809-6819. DOI: 10.1021/acsami.8b20634.
[35] Yuan W, Xia D, Wu S, et al.A review on current research status of the surface modification of Zn-based biodegradable metals[J]. Bioact Mater, 2022, 7:192-216. DOI: 10.1016/j.bioactmat.2021.05.018.
[36] Yan ZY, Zhu JH, Liu GQ, et al.Feasibility and efficacy of a degradable magnesium-alloy GBR membrane for bone augmentation in a distal bone-defect model in beagle dogs[J]. Bioinorg Chem Appl, 2022, 2022:4941635. DOI: 10.1155/2022/4941635.
[37] Rakhmatia YD, Ayukawa Y, Furuhashi A, et al.Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications[J]. J Prosthodont Res, 2013, 57(1):3-14. DOI: 10.1016/j.jpor.2012.12.001.