Abstract: Biological calcium phosphate-based bone substitutes have been widely used in the rehabilitation of bone defects in implant dentistry, due to their great biocompatibility and osteoconductivity. It has become an important optimizing strategy for bone regeneration materials through trace elements incorporation and controlled release to promote osteogenesis by regulating the regenerative microenvironment. In recent years, a series of studies have shown that fluorinated porcine bone substitute has good mechanical properties and the capacity of fluorine slow-release which could promote bone regeneration by activating the Wnt/β-catenin signaling pathway and regulating the immune microenvironment. Such an in vitro effect of fluorinated porcine bone substitute has been evidently proven in a variety of subsequent studies in vivo. This article summarized the research progress of the fluorinated porcine bone substitute so as to provide a reference for related basic research and clinical application.

Key words: Biological bone substitutes, Fluoride, Bone regeneration, Osteoimmunomodulation