可降解锌基金属生物屏障膜的研究进展

doi:10.12337/zgkqzzxzz.2023.02.004

中国口腔种植学杂志 ›› 2023, Vol. 28 ›› Issue (1): 19-25.DOI: 10.12337/zgkqzzxzz.2023.02.004

可降解锌基金属生物屏障膜的研究进展

徐淑兰, 陈家豪

南方医科大学口腔医院种植中心,广州 510280

收稿日期:2022-10-27 出版日期:2023-02-28 发布日期:2023-03-07
通讯作者: 徐淑兰,Email：xushulan_672588@smu.edu.cn,电话：020-84408890
作者简介:徐淑兰主任医师、教授、南方医科大学研究生导师、博士后合作导师。南方医科大学口腔医院（广东省口腔医院）副院长。中华口腔医学会第六届口腔种植专业委员会副主任委员,广东省医学教育协会口腔种植学专业委员会主任委员,广东省口腔医学会口腔种植专业委员会副主任委员,广东省临床医学学会牙种植学专业委员会副主任委员,广东省医师协会口腔医师分会副主任委员,教育部学位中心评审专家。
基金资助:
广东省基础与应用基础研究基金（2021A1515111140和2021B1515120059）; 南方医科大学口腔医院科研培育项目（PY2022002, PY2021003和PY2020011）; 广州市科技项目（202102080148）

Research progress of zinc-based biodegradable metals for biological barrier membrane

Xu Shulan, Chen Jiahao

Center of Oral Implantology, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China

Received:2022-10-27 Online:2023-02-28 Published:2023-03-07
Contact: Xu Shulan, Email: xushulan_672588@smu.edu.cn, Tel: 0086-20-84408890
Supported by:
Guangdong Basic and Applied Basic Research Foundation （2021A1515111140 and 2021B1515120059）; Science Research Cultivation Program of the Stomatological Hospital, Southern Medical University （PY2022002, PY2021003 and PY2020011）; Science and Technology Projects in Guangzhou （202102080148）

摘要/Abstract

摘要： 引导骨再生（guided bone regeneration, GBR）是最常见的骨增量手术,而其效果受到生物屏障膜的材料特性所影响。鉴于现有的生物屏障膜无法同时满足生物相容性好、力学强度高、降解可控、生物活性佳且易操作性等临床需求,亟待研发一种新型生物屏障膜材料。可降解金属（biodegradable metals, BMs）是指一种预期在体内降解的金属。其中,锌基BMs因其优异的材料特性,有望成为新一代生物屏障膜材料。然而,锌基生物屏障膜仍处于基础研究阶段。在此,笔者结合团队前期的研究工作,基于今后的临床应用考虑,系统地阐析锌基生物屏障膜在生物相容性、力学性能、降解性能和生物活性四个方面的研究进展及不足,为促进其临床转化提供科学依据。

关键词: 生物屏障膜, 生物可降解金属, 力学性能, 降解性能, 生物响应

Abstract: Guided Bone Regeneration (GBR) is the most common bone augmentation procedure in implant dentistry, and the effect of bone augmentation is determined by the material properties of the biological barrier membranes. However, are current biological barrier membranes are insufficient for all clinical requirements, including excellent biocompatibility, high mechanical properties, controllable degradation behavior, superior bioactivity, and easy clinical management. It is required to develop and investigate a novel material for the biological barrier membrane. Biodegradable metals (BMs) refer to metals that are intended to degrade in vivo. Among them, zinc(Zn)-based BMs are regarded as a novel generation of biological barrier membrane materials due to their excellent material properties. Nevertheless, Zn-based biological barrier membranes have been still in the stage of research and development. Based on our previous research studies and considering the future clinical applications, this paper systematically reviewed the research status and drawbacks of Zn-based biological barrier membranes in terms of four aspects: biocompatibility, mechanical properties, biodegradability, and bioactivity, providing scientific evidence to promote its clinical transformation.

Key words: Biological barrier membrane, Biodegradable metals, Mechanical property, Degradation behavior, Biological response

徐淑兰,等陈家豪. 可降解锌基金属生物屏障膜的研究进展[J]. 中国口腔种植学杂志, 2023, 28(1): 19-25. DOI: 10.12337/zgkqzzxzz.2023.02.004

Xu Shulan, Chen Jiahao. Research progress of zinc-based biodegradable metals for biological barrier membrane[J].Chinese Journal of Oral Implantology, 2023, 28(1): 19-25.DOI: 10.12337/zgkqzzxzz.2023.02.004.

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可降解锌基金属生物屏障膜的研究进展

Research progress of zinc-based biodegradable metals for biological barrier membrane

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