中国口腔种植学杂志 ›› 2021, Vol. 26 ›› Issue (5): 328-333.DOI: 10.12337/zgkqzzxzz.2021.10.011

• 综述 • 上一篇    下一篇

纳米材料在口腔医学中的应用及机制研究进展

张涵1, 孟令汐1, 王弥粲1, 陆经纬1, 梅宏翔1, 廖文1,2   

  1. 1口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院,成都 610041;
    2四川大学华西口腔医院正畸科,成都 610041
  • 收稿日期:2021-01-07 出版日期:2021-10-30 发布日期:2021-11-12
  • 通讯作者: 廖文,Email:liaowenssw@126.com,电话:028-85505406
  • 作者简介:张涵,学士,研究方向:口腔正畸学,口腔材料学;廖文,博士,副教授,四川大学华西口腔医院正畸科。研究方向:口腔正畸学,口腔材料学,生物力学
  • 基金资助:
    四川省科技项目(20ZDYF2839); 四川大学-泸州市人民政府战略合作项目(2018CDLZ-14); 四川大学大学生创新创业训练计划(C201910610531)

Research progress on the application and mechanism of nanomaterials in stomatology

Zhang Han1, Meng Lingxi1, Wang Mican1, Lu Jingwei1, Mei Hongxiang1, Liao Wen1,2   

  1. 1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
    2Department of Orthodontics, West China Hospital of Stomatology, Sichuan University Chengdu 610041, China
  • Received:2021-01-07 Online:2021-10-30 Published:2021-11-12
  • Contact: Liao Wen, Email: liaowenssw@126.com, Tel: 0086-28-85505406

摘要: 由于纳米材料具有优越的抗菌性能及生物相容性等特性,其在口腔疾病防治领域,尤其是控制龋病发生发展、缓解牙本质过敏等领域中得到广泛应用。同时,纳米材料因具备颗粒小、抗菌活性高、生物相容性好的特性,为组织再生领域,尤其是口腔组织再生提供了新的解决方案。目前,纳米材料在口腔医学领域的研究主要集中于各种颗粒型纳米材料对不同口腔细胞的生物学效应及临床应用研究中。本文将对纳米颗粒口腔相关细胞的生物学效应、潜在机制以及影响因素出发进行综述,旨在为口腔医疗领域中新材料的研发和口腔疾病的预防、诊断、治疗提供参考。

关键词: 纳米颗粒, 纳米技术, 口腔医学, 作用机制

Abstract: Nanomaterials have been widely used in the field of oral disease prevention and treatment, especially in controlling the development of caries and alleviating dentin allergy, due to their superior antibacterial properties and biocompatibility. Meanwhile, nanomaterials provide solutions for tissue regeneration, especially for oral tissue regeneration, due to their small particle size, high antibacterial activity and biocompatibility. At present, the research on nanomaterials in the field of dentistry focuses on the biological effects of various nanomaterials on different oral cells and clinical application studies. In this paper, we will review the biological effects of nanoparticles on oral cells, potential mechanisms and influencing factors, aiming to provide references for the development of new materials in the field of oral medicine and the prevention, diagnosis and treatment of oral diseases.

Key words: Nanoparticles, Nanotechnology, Stomatology, Mechanisms