抗菌光动力疗法在种植体周围疾病中的应用

doi:10.12337/zgkqzzxzz.2021.06.002

摘要/Abstract

摘要： 抗菌光动力疗法（antimicrobial photodynamic therapy,aPDT）的基本原理是通过特定波长的可见光与光敏剂相互作用,产生单线态氧等细胞毒性物质,以杀死目标细菌/细胞。在种植体周围疾病的治疗中,因单纯使用机械清创术存在一定局限性,aPDT作为一种新型辅助疗法在临床上逐渐展开应用。尽管单个研究表明,aPDT可在短期内改善种植体周围疾病的临床指标,尤其是在吸烟及糖尿病患者中展现出潜在的应用前景;但高等级证据资料（指南共识、系统评价等）并未推荐将其作为种植体周围疾病的常规疗法。未来的研究方向应专注于规范aPDT的操作流程,从而建立高质量的临床研究证据以验证其长期疗效。

关键词: 抗菌光动力疗法, 光敏剂, 机械清创, 种植体周围疾病, 种植体周炎

Abstract: The basic principle of antimicrobial photodynamic therapy (aPDT) is to produce singlet oxygen and other cytotoxic substance through the interaction of visible light of a specific wavelength with the photosensitizer, to kill the targeted bacteria/cell. Because of the limitations of mechanical debridement, aPDT has been applied clinically as a novel adjunctive therapy. Although existing single studies demonstrated improvement of peri-implant parameters in a short term, and has shown potential application prospects, especially in smoking and diabetes patients; high-level evidence (guideline consensus, systematic reviews, etc.) did not recommend aPDT as a routine therapy for peri-implant diseases. Future research should focus on standardizing the procedures of aPDT in order to establish high-quality clinical evidence to verify its long-term efficacy.

Key words: Antimicrobial photodynamic therapy, Photosensitizer, Mechanical debridement, Peri-implant disease, Peri-implantitis

施斌,等晏奇,等赵耀宇. 抗菌光动力疗法在种植体周围疾病中的应用[J]. 中国口腔种植学杂志, 2021, 26(3): 152-158. DOI: 10.12337/zgkqzzxzz.2021.06.002

Shi Bin, Yan Qi, Zhao Yaoyu. Clinical application of antimicrobial photodynamic therapy in the treatment of peri-implant diseases[J].Chinese Journal of Oral Implantology, 2021, 26(3): 152-158.DOI: 10.12337/zgkqzzxzz.2021.06.002.

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