Abstract: This report presents a case of 3D printing individualized titanium mesh (3D-PITM) combined with guided bone regeneration (GBR) applied in digital implant restoration of severe bone defects in the anterior esthetic zone. The patient suffered from continuous loss of natural teeth and severe bone defects in the anterior esthetic zone due to trauma, which seriously affected appearance and function. The 3D-PITM combined with GBR surgery was performed for bone augmentation, and the implant was placed with the assistance of a CAD/CAM implant surgical guide and subsequently restored. Six months after 3D-PITM combined with GBR, the bone width at site 11 increased from 3.72 mm preoperatively to 7.31 mm, and the bone height increased from 14.11 mm preoperatively to 15.97 mm; the bone width at site 21 increased from 3.58 mm preoperatively to 7.41 mm, and the bone height increased from 11.97 mm preoperatively to 15.59 mm. The expected bone augmentation effect was obtained. The alveolar bone contour was reconstructed, and sufficient bone volume was provided for “prosthetic-driven” precise implant placement. Osteogenesis was stable during postoperative follow-up, and there was no obvious marginal bone resorption. The pink esthetic score (PES), white esthetic score (WES), and patient satisfaction visual analogue scale (VAS) were evaluated immediately after crown delivery, at 6 months, and at 12 months. The results showed that the esthetic outcome was good and stable, with significant improvement in anterior esthetics and function.

Key words: 3D printing individualized titanium mesh, Guided bone regeneration, Severe bone defect, Digital, Implant restoration