Abstract: Objective: This study is aimed to investigate the clinical effect of minimally invasive immediate im-plant restoration in maxillary aesthetic zone with multiple teeth loss. Methods: This study did the immedi-ate implant surgery with bone expansion and bone augmentation technique in a minimally invasive flap-less way using 2 Nobel-Replace bone level implants. And the permanent restoration was performed 6 months after the implant surgery. The synosteosis and periprosthetic soft tissue were observed 3, 30, 72 months later. Results: The synosteosis was well formed and the impants were stable after long-term load-ed. And the periprosthetic soft tissue had healthy pink aesthetics and proper white aesthetics. The treat-ment effect was beyond expectation and the patient left with great satisfaction. Conclusion: The minimal-ly invasive immediate implant restoration can meet both the functional and aesthetic demand of the pa-tients with multiple teeth loss in maxillary aesthetic zone which is significant in clinical therapy to some degree.

Key words: aesthetic zone, multiple teeth loss, minimally invasive, immediate implant, bone aug-mentation