Progress in research on genes associated with tooth agenesis

doi:10.12337/zgkqzzxzz.2024.06.005

Abstract

Abstract: Tooth agenesis, a prevalent oral disease, remains partially elusive in terms of its underlying pathogenic mechanism. Recent breakthroughs have elucidated a series of pathogenic genes associated with this condition, whose encoded proteins play key roles in regulating and guiding normal tooth germ development through essential signaling pathways. This review focuses on genes related to congenital tooth agenesis and their involvement in the signaling pathways of tooth developrnet. As research progreses, especialy through the use of model animal, insights into the pathogenic processes of this developmental anomaly may lead to effective strategies for treating congenital tooth agenesis by modulating the function of these genes or repairing defects in signal transmission.Moreover, this article also discusses the clinical characteristics of congenital tooth agenesis-causing genes observed in human patients and explores the potential link between these genes and the occurrence of tumors.

Key words: Tooth agenesis, Pathogenesis, Odontogenesis signaling

Zhang Han, Sun Yao. Progress in research on genes associated with tooth agenesis[J]. Chinese Journal of Oral Implantology, 2024, 29(3): 218-223.

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