The immune microenvironment remodeling of the coagulation-immune complex based on the control of blood clot fibrin network

doi:10.12337/zgkqzzxzz.2022.12.007

Abstract

Abstract: The immune microenvironment of the early wound is the important stage that influences the outcome of tissue repair and regeneration. There is some overlap between the early immune microenvironment and the blood coagulation process including blood infiltration, clot formation, and its organization, as their biological processes involve many of the same immune cell clusters and cytokines. In recent years, it has been found that the fibrin network in clots can act on immune cells in several ways and be involved in shaping the immune microenvironment. Therefore, it has great significance to reveal the immunoregulatory targets of the clot fibrin network and to elucidate the regulatory laws. To address this coagulation-immune complex, we first clarify the effect of the blood clot and its fibrin network on tissue regeneration, further reveal the biological basis of the fibrin networks involvement in shaping the immune microenvironment, and finally introduce new advances in the regulation of the coagulation-immune complex immune microenvironment based on the fibrous network control. This review aims to provide ideas for the development of a new generation of immune-intelligent regenerative materials.

Key words: Clot, Fibrin network, Immune microenvironment, Coagulation-immune complex

Su Mengxi, Wu Shiyu, Shan Zhengjie, Xie Lv, Wu Xiayi, Chen Zetao, Chen Zhuofan. The immune microenvironment remodeling of the coagulation-immune complex based on the control of blood clot fibrin network[J]. Chinese Journal of Oral Implantology, 2022, 27(6): 365-370.

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