益生菌在口腔种植体周疾病中的应用

doi:10.12337/zgkqzzxzz.2025.02.016

中国口腔种植学杂志 ›› 2025, Vol. 30 ›› Issue (1): 91-96.DOI: 10.12337/zgkqzzxzz.2025.02.016

• 综述 • 上一篇

益生菌在口腔种植体周疾病中的应用

李美琪, 孙晓琳, 王林

吉林大学口腔医学院口腔医院种植科,长春 130021

收稿日期:2024-11-06 出版日期:2025-02-28 发布日期:2025-02-24
通讯作者: 孙晓琳,Email：sxl2673366@126.com,电话：0431-88796025;王林,Email：wanglin1982@jlu.edu.cn,电话：0431-88796025
作者简介:李美琪,硕士研究生,研究方向：口腔多功能纳米材料的生物学应用;孙晓琳,医学博士、副教授、副主任医师、博士研究生导师,研究方向：口腔种植修复材料、纳米材料的构建及应用;王林,医学博士、教授、主任医师、博士研究生导师,研究方向：口腔种植修复材料、口腔多功能纳米材料
基金资助:
吉林省自然科学基金（YDZJ202401209ZYTS）; 吉林省科技厅重点研发项目（20220203145SF）

Application of probiotics in the management of peri-implant diseases

Li Meiqi, Sun Xiaolin, Wang Lin

Department of Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, Jilin, China

Received:2024-11-06 Online:2025-02-28 Published:2025-02-24
Contact: Sun Xiaolin, Email: sxl2673366@126.com, Tel: 0086-431-88796025; Wang Lin, Email: wanglin1982@jlu.edu.cn, Tel: 0086-431-88796025
Supported by:
Natural Science Foundation of Jilin Province (YDZJ202401209ZYTS); Key Research and Development Project of Jilin Provincial Science and Technology Department (20220203145SF)

摘要/Abstract

摘要： 种植体周疾病是一种由微生物群失调引起的慢性炎症反应,主要表现为软组织炎症和支持骨破坏,甚至导致种植体脱落,该疾病因发病率高和病因复杂而成为公共卫生问题。目前,种植体周疾病的治疗主要依靠机械清创和抗生素应用等传统方法,但这些方法存在一定的局限性。近年来,利用益生菌治疗作为新兴的生物疗法日益受到关注,益生菌能够调节微生物群和免疫反应,显示出在种植体周疾病防治中的潜力。本文综述了益生菌在口腔种植体周疾病中的应用现状,分析其作用机制,并总结当前的临床研究成果,为提高种植体周疾病治疗效果提供新思路,也为患者提供全面的口腔健康管理方案。

关键词: 益生菌, 种植体周炎, 口腔微生物群, 抗炎机制, 临床应用

Abstract: Peri-implant diseases are chronic inflammatory conditions caused by microbial dysbiosis, primarily manifesting as soft tissue inflammation and supporting bone destruction, which can lead to implant loss. Due to their high prevalence and complex etiology, these diseases have emerged as significant public health concerns. Current treatments mainly rely on traditional methods such as mechanical debridement and antibiotic therapy; however, these approaches have notable limitations. In recent years, probiotics have garnered attention as an emerging biological therapy due to their potential to regulate the microbiome and immune response, showing promise in the prevention and treatment of peri-implant diseases. This review provides an overview of the current applications of probiotics in peri-implant diseases, analyzes their mechanisms of action, and summarizes existing clinical research findings. The goal is to provide new insights for improving treatment outcomes in peri-implant diseases, ultimately aiming to offer patients a more comprehensive oral health management strategy.

Key words: Probiotics, Peri-implantitis, Oral microbiota, Anti-inflammatory mechanisms, Clinical applications

李美琪,孙晓琳,王林. 益生菌在口腔种植体周疾病中的应用[J]. 中国口腔种植学杂志, 2025, 30(1): 91-96. DOI: 10.12337/zgkqzzxzz.2025.02.016

Li Meiqi, Sun Xiaolin, Wang Lin. Application of probiotics in the management of peri-implant diseases[J].Chinese Journal of Oral Implantology, 2025, 30(1): 91-96.DOI: 10.12337/zgkqzzxzz.2025.02.016.

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益生菌在口腔种植体周疾病中的应用

Application of probiotics in the management of peri-implant diseases

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